Navigation Links
Why smoking is 'BAD' for the Fallopian tube -- and increases the risk of ectopic pregnancy
Date:7/3/2012

Istanbul, 3 July 2012: Cigarette smoke reduces the production of a Fallopian tube gene known as "BAD", which helps explain the link between smoking and ectopic pregnancy. The finding, from scientists led by Drs Andrew Horne and Colin Duncan at the Medical Research Council (MRC) Centre for Reproductive Health in Edinburgh, UK, was described today at the annual meting of ESHRE (European Society of Human Reproduction and Embryology) in Istanbul.

Ectopic pregnancy - when the embryo implants outside the uterus and in the Fallopian tube - occurs in up to 2% of all pregnancies and is the most common cause of maternal death in early pregnancy. There is currently no way to prevent an ectopic pregnancy, and the condition must be treated by abdominal surgery or, when the ectopic is small and stable, by injection of a drug called methotrexate.

In presenting background information to the study, Dr Horne explained that ectopic pregnancy is the result of a combination of factors affecting the transport of the developing embryo from the Fallopian tube to the uterus and changes in the tubal environment which allow early implantation to occur. Smoking is known to be a major risk factor, but how smoking changes the environment of the Fallopian tube for an ectopic pregnancy to occur has so far remained largely unknown.

For the purpose of this study, Dr Horne's group first exposed cells from the Fallopian tube to a breakdown product of nicotine called cotinine. They then showed that cotinine had a negative effect on genes known to be associated with cell death (or apoptosis), and in particular with a gene called BAD. In a further study the researchers showed that BAD expression was reduced in the Fallopian tube of women who were smokers.

Dr Horne explained that changes in the production of BAD and related genes are seen in the uterus as it prepares for normal implantation of the embryo and early pregnancy. A reduction in the expression of BAD is normally seen in the cells of the uterus just before the embryo implants.

The results of this study, said Dr Horne, suggest that the reduced production of the BAD gene in the Fallopian tube leads to an environment like that of the uterus, which encourages and allows ectopic pregnancy to occur. "So our research," he added, "may in future help scientists find ways to prevent ectopic pregnancy, diagnosis it better, and treat it earlier."

He went on: "The research is exciting because it provides new scientific evidence to help understand why women who smoke are more likely to have ectopic pregnancies. It appears that smoking reduces the production of genes such as BAD which are involved in the control of cell death and promote an environment in the Fallopian tube which is attractive to the developing embryo.

"The information gained from this study can also be applied to other conditions caused by smoking, and could help us prevent or treat them better in the long term."


'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Anti-tobacco TV ads help adults stop smoking, study finds
2. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
3. Small neural focus groups predict anti-smoking ad success
4. Some women may be genetically predisposed to smoking-related hot flashes
5. Friends Parents Can Sway Teens Odds for Drinking, Smoking
6. Fewer Young Americans Smoking, Survey Finds
7. Vitamin C improves pulmonary function in newborns of pregnant smoking women
8. Genetic marker may predict smoking quantity in African Americans
9. 5 percent of workers gave up smoking when the anti-tobacco law took effect
10. Vitamin C improves lung function in newborns of pregnant smoking women
11. States Use Only Fraction of Tobacco Revenues to Fight Smoking, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett is ... these scholarships is to encourage applicants to pursue a degree in their field of ... parishes. , “We have available jobs in St. Landry and Evangeline Parishes that ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... — 1:30 p.m. – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination ... cycle of pharmaceutical products, garnering increased attention from all stakeholders in the development ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... announced that nominations have closed for the ISE Southeast Awards 2016. Finalists and ... announced at the ISE® Southeast Executive Forum and Awards Gala on March 15, ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman and CEO Kenneth Fisher ... Military Support Alliance president Scott Bensing, and Peggy Kearns Director, VA Southern Nevada Healthcare ... System. This will be the first Fisher House in Nevada, and will provide ...
(Date:2/12/2016)... ... February 12, 2016 , ... Erlanger Agency has announced a new partnership in ... latest campaign focuses on the fight against breast cancer, fundraising for a local woman ... here . , Carmen is a loving single mother of two boys who also ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Stem cells are primitive cells found in all multi-cellular ... to differentiate into mature cell types Stem cells are ... embryonic stem cells were derived from embryos in 1981, ... culturing of embryonic stem cells from non-human primates occurred ... As a result of these discoveries, stem cells can ...
(Date:2/11/2016)... 2016  Kindred Biosciences, Inc. (NASDAQ: KIN ), ... lives of pets, today announced the submission to FDA ... Drug Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  Positive ... Zimeta for the control of pyrexia (fever) in horses ... --> --> The Chemistry, Manufacturing, and ...
(Date:2/11/2016)...   Health 2.0 , the premiere showcase and ... today " 10 Year Global Retrospective ", a platform ... past ten years.   --> ... has served as the preeminent thought-leader in the health ... technologies, companies, innovators, and patient-activists through an array of ...
Breaking Medicine Technology: