Why prostate cancer patients fail hormone deprivati... (patients who had never taken hormone the...)

Navigation Links

Biology News Medicine News Biology Products Medicine Products Biology Definition Medicine Definition Biology Technology Medicine Technology Biology Dictionary Medicine Dictionary

HOME >> MEDICINE >> NEWS

Why prostate cancer patients fail hormone deprivation therapy

Date:12/31/2008

patients who had never taken hormone therapy, but whose cancer aggressively regrew after surgery to remove their tumors.

To see how androgen receptors made from AR-V7 differ from others, the researchers forced lab-grown prostate cancer cells to produce only the AR-V7 sequence. Unlike cells with other androgen receptors, those with only AR-V7 receptors acted as if they were continually receiving androgensturning on at least 20 genes that rely on androgens for activationeven though no androgens were present.

The results suggest that hormone therapy might encourage prostate cancer cells to overproduce the AR-V7 receptors over time, leading them to survive and grow aggressively even without androgens, explains Luo. In some patients, he adds, AR-V7 receptors might already be prevalent even without hormone therapy, predisposing them to an already-aggressive form of prostate cancer that won't respond as well to hormone deprivation therapy.

"We may eventually be able to develop an assay to test for this androgen receptor variant, giving us a way to test which patients are good candidates for hormone deprivation therapy and providing a way to monitor disease progression in patients already on this therapy," Luo says.

Examining the differences between AR-V7 and other androgen receptor variants may also provide researchers with new ideas to develop prostate cancer-fighting pharmaceuticals, he adds.

'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

1

GOOD

Page: 1 2
Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. First biomarker discovered that predicts prostate cancer outcome
3. Frequent Prostate Screens Fail to Improve Aggressive Cancer Diagnoses
4. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
5. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
6. Red wine compound shown to prevent prostate cancer
7. Barbershop Talks Cut Black Mens Prostate Cancer Risk
8. Generic prostate drug helps find high-risk cancers early
9. Finasteride unlikely to induce high grade prostate cancers
10. Shrinkage of prostate led to overestimation of cancer risk in trial
11. Prostate Cancer Awareness Week to Screen Thousands

Post Your Comments:

Breaking Medicine News(10 mins):Health News:The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website 2 Health News:The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website 3 Health News:Senator Ben Nelson Puts U.S. Bishops' Interests Ahead of Americans' Healthcare Needs 2 Health News:Secure-24 and ATMP Consulting Group Launch Partnership for Private Practice Physicians to Meet IT and Electronic Medical Record Standards 2 Health News:Secure-24 and ATMP Consulting Group Launch Partnership for Private Practice Physicians to Meet IT and Electronic Medical Record Standards 3 Health News:VitaminSpice Signs Agreement With Former CEO of Wal-Mart Stores Division for US Distribution 2 Health News:Prostate Hormone Therapy May Up Heart Risks 2 Health News:Prostate Hormone Therapy May Up Heart Risks 3

[0] The Flag Company, Inc.'s Recently Released “Feel Good” Light Lenses Grows Into Its Own Website [1] Senator Ben Nelson Puts U.S. Bishops' Interests Ahead of Americans' Healthcare Needs [0] Secure-24 and ATMP Consulting Group Launch Partnership for Private Practice Physicians to Meet IT and Electronic Medical Record Standards [1] VitaminSpice Signs Agreement With Former CEO of Wal-Mart Stores Division for US Distribution [0] Prostate Hormone Therapy May Up Heart Risks

Novel compound may lessen heart attack damage MedCath Corporation Reports First Quarter Earnings Pharmaceutical Product Commercialization & Governance Best Practices: Securing Talent for Highly-Effective Brand Teams DRAXIS Health Reports Fourth Quarter and Year End Results Can a Video Game Make Your Kids More Fit?Nuvelo Announces Upcoming Conference Calls, Webcasts and Conference Participation

Breaking Medicine Technology:Genoptix Announces Participation at Deutsche Bank 2009 MedTools Investor Conference 2 Successful Phase I/II Clinical Trial for BiondVax Pharmaceuticals' Universal Flu Vaccine 2 Successful Phase I/II Clinical Trial for BiondVax Pharmaceuticals' Universal Flu Vaccine 3 Successful Phase I/II Clinical Trial for BiondVax Pharmaceuticals' Universal Flu Vaccine 4 Successful Phase I/II Clinical Trial for BiondVax Pharmaceuticals' Universal Flu Vaccine 5 New FDA Approved Breast Cancer Screening Tool 2 New FDA Approved Breast Cancer Screening Tool 3 House Energy 26 Commerce Committee Accepts Independence at Home Pilot Program as Amendment During Health Bill Markup 53369 1 House Energy 26 Commerce Committee Accepts Independence at Home Pilot Program as Amendment During Health Bill Markup 53369 2 Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday August 4 2009 After Close of U S Based Financial Markets 13310 1 Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday August 4 2009 After Close of U S Based Financial Markets 13310 2 Breast CT Scanner Could Improve Cancer Screen Comfort 53364 1 Breast CT Scanner Could Improve Cancer Screen Comfort 53364 2 Breast CT Scanner Could Improve Cancer Screen Comfort 53364 3

[0] Genoptix Announces Participation at Deutsche Bank 2009 MedTools Investor Conference [0] Successful Phase I/II Clinical Trial for BiondVax Pharmaceuticals' Universal Flu Vaccine [0] New FDA Approved Breast Cancer Screening Tool

Other Medicine Technology:Genetic Research Leads to New Discovery in Understanding Rare Neurological Disorder 2 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 2 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 3 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 4 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 5 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 6 Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile 7

Genetic Research Leads to New Discovery in Understanding Rare Neurological Disorder Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile

Medicine Products:

Stainless Steel Locking Pliers Double Action Wire Cutter optomap Retinal Examination SR - Single Rectangular Head Camera

Why prostate cancer patients fail hormone deprivati...(patients who had never taken hormone the...),Health