Navigation Links
Why people with schizophrenia may have trouble reading social cues
Date:5/24/2011

NASHVILLE, Tenn.Understanding the actions of other people can be difficult for those with schizophrenia. Vanderbilt University researchers have discovered that impairments in a brain area involved in perception of social stimuli may be partly responsible for this difficulty.

"Misunderstanding social situations and interactions are core deficits in schizophrenia," said Sohee Park, Gertrude Conaway Professor of Psychology and one of the co-authors on this study. "Our findings may help explain the origins of some of the delusions involving perception and thoughts experienced by those with schizophrenia."

In findings published in the journal PLoS ONE, the researchers found that a particular brain area, the posterior superior temporal sulcus or STS, appears to be implicated in this deficit.

"Using brain imaging together with perceptual testing, we found that a brain area in a neural network involved in perception of social stimuli responds abnormally in individuals with schizophrenia," said Randolph Blake, Centennial Professor of Psychology and co-author. "This brain area fails to distinguish genuine biological motion from highly distorted versions of that motion."

The study's lead author, Jejoong Kim, completed the experiments as part of his dissertation under the supervision of Park and Blake in Vanderbilt's Department ofPsychology. Kim is now conducting research in the Department of Brain and Cognitive Sciences at Seoul National University in Korea, where Blake is currently a visiting professor.

"We have found that people with schizophrenia tend to 'see' living things in randomness and this subjective experience is correlated with an increased activity in the (posterior) STS," the authors wrote. "In the case of biological motion perception, these self-generated, false impressions of meaning can have negative social consequences, in thatschizophrenia patients may misconstrue the actions or intentions of other people."

In their experiments, the researchers compared the performance of people with schizophrenia to that of healthy controls on two visual tasks. One task involved deciding whether or not an animated series of lights depicted the movements of an actor's body. The second task entailed judging subtle differences in the actions as depicted by two animations viewed side by side. On both tasks, people with schizophrenia performed less well than the healthy controls.

Next, the researchers measured brain activity using functional magnetic resonanceimaging (fMRI) while the subjectshealthy controls and schizophrenia patientsperformed a version of the side-by-side task. Once again, the individuals with schizophrenia performed worse on the task. The researchers were then able to correlate those performance deficits with the brain activity in each person.

The fMRI results showed strong activation of the posterior portion of the STS in the healthy controls when they were shown biological motion. In the individuals with schizophrenia, STS activity remained relatively constant and high regardless of what was presented to them.

Analysis of the brain activity of the schizophrenia patients also showed high STS activity on trials where they reported seeing biological motion, regardless of whether the stimulus itself was biological or not.

For reasons yet to be discovered, area STS in schizophrenia patients fails to differentiate normal human activity from non-human motion, leading Kim and colleagues to surmise that this abnormal brain activation contributes to the patients' difficulties reading social cues portrayed by the actions of others.


'/>"/>

Contact: Melanie Moran
melanie.moran@vanderbilt.edu
615-322-2706
Vanderbilt University
Source:Eurekalert

Related medicine news :

1. Depressed people feel more gray than blue
2. Exercise Success for People Over 50: Reports of Improved Fitness, Circulation and Balance
3. Vaccine May Prevent TB in People With HIV
4. People with anxiety disorder less able to regulate response to negative emotions, study shows
5. Can mobile phones help people EatWell?
6. “Hearts and Minds” Education Program Launched: On Average, People with Mental illness Live 25 Years Less than Other Americans
7. Happy People More Likely to Try Something New
8. Board Certified Renal Specialist, Nina Kolbe, Publishes Second Edition of Kidney Health Gourmet: A Diet Guide and Kidney Friendly Recipes for People Not on Dialysis
9. Visual Cues that Improve Walking for People with Movement Disorders - Study Shows Small Change in Arrangement Can Make a Big Difference in Improvement Gained
10. Pelosi on Repealing Antitrust Exemption: Health Insurance Companies Will Now Be Playing on the Peoples Field
11. Gingrich Hosts The American Peoples Online Health Summit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Accreditation Commission for ... Care Association of America (HCAOA). This agreement allows HCAOA members to receive special ... as discounts on Accreditation University (AU) educational resources that help prepare HCAOA members ...
(Date:4/28/2017)... , ... April 28, 2017 , ... Horizon Blue Cross ... the company’s credit rating of “A” and its outlook as “stable.” At the same ... reserves, which have fallen in recent years, dip below “capital adequacy” thresholds required for ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... Replace tubes . These lamps offer an instant energy-saving solution for F32T8 fluorescent ... rewire fixtures or disconnect ballasts. These 50,000 hour rated lamps utilize the existing ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Texas Cord Blood Bank (TCBB), a program ... delivery team at Women’s Hospital at Renaissance in Edinburg for their outstanding efforts in ... and decide to donate. , “Women’s Hospital at Renaissance has been a collection ...
(Date:4/28/2017)... ... April 28, 2017 , ... Bill Howe started his sewer and drain ... After Tina Howe joined the team, the Bill Howe brand was born and they ... rates, and giving back to the San Diego community in which they worked, lived ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... DUBLIN , April 20, 2017 Research ... Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and ... to their offering. ... market for drug delivery technologies will rise from USD 20 Billion ... Global Drug Delivery Technologies - Innovation Driven by Rapidly ...
(Date:4/20/2017)... Research and Markets has announced the ... Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies ... ... was valued at US$ 7,167.6 Mn in 2015, and is ... a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/19/2017)... 19, 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the ... Co. Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Chief Executive Officer of the Company is scheduled to present on ... Bear and the Chairman of the Board, Tony Holler ... ...
Breaking Medicine Technology: