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Why is late-life depression harder to treat?
Date:5/4/2010

Toronto Scientists have found an important clue in the quest to understand why people who suffer from depression in later life are harder to treat and keep well in the long term.

A study led by Toronto's Baycrest has found that older adults with depression don't respond normally to emotional stimuli, such as when they see happy, sad or neutral faces.

The study appears online this week in the American Journal of Geriatric Psychiatry and is likely the first published data to focus specifically on emotional processing in un-medicated older adults with late-life depression.

"In our study we found significant differences between older depressed subjects and older healthy subjects in how they emotionally respond to and perceive facial expressions," said principal investigator Dr. Linda Mah, a clinician-scientist in the Mood Clinic at Baycrest.

Emotion dysregulation is already well established in mid-life depression and some studies have shown it to be predictive of a relapse of mood symptoms. But the majority of late-life depression studies have concentrated on the link with cognitive decline, suggesting that the more impaired the cognitive functions the greater the chances of a poor prognosis in depression.

"Our data suggest that we need to also focus on emotion to better understand the neurobiology of late-life depression, so we can treat it more effectively and help people feel better longer," said Dr. Mah.

In the study, 11 un-medicated outpatients with major depressive disorder, and 11 healthy comparison subjects, participated in two tasks that involved looking at photographs of faces with happy, sad, fearful or neutral expressions. The age range of participants was 60 to 87.

In the first task, participants were asked to make judgments regarding a physical feature of faces, rather than judging the emotional expression. In the second task, participants were asked to label the emotional exp
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Contact: Kelly Connelly
kconnelly@baycrest.org
416-785-2432
Baycrest Centre for Geriatric Care
Source:Eurekalert

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