Navigation Links
Why is late-life depression harder to treat?

Toronto Scientists have found an important clue in the quest to understand why people who suffer from depression in later life are harder to treat and keep well in the long term.

A study led by Toronto's Baycrest has found that older adults with depression don't respond normally to emotional stimuli, such as when they see happy, sad or neutral faces.

The study appears online this week in the American Journal of Geriatric Psychiatry and is likely the first published data to focus specifically on emotional processing in un-medicated older adults with late-life depression.

"In our study we found significant differences between older depressed subjects and older healthy subjects in how they emotionally respond to and perceive facial expressions," said principal investigator Dr. Linda Mah, a clinician-scientist in the Mood Clinic at Baycrest.

Emotion dysregulation is already well established in mid-life depression and some studies have shown it to be predictive of a relapse of mood symptoms. But the majority of late-life depression studies have concentrated on the link with cognitive decline, suggesting that the more impaired the cognitive functions the greater the chances of a poor prognosis in depression.

"Our data suggest that we need to also focus on emotion to better understand the neurobiology of late-life depression, so we can treat it more effectively and help people feel better longer," said Dr. Mah.

In the study, 11 un-medicated outpatients with major depressive disorder, and 11 healthy comparison subjects, participated in two tasks that involved looking at photographs of faces with happy, sad, fearful or neutral expressions. The age range of participants was 60 to 87.

In the first task, participants were asked to make judgments regarding a physical feature of faces, rather than judging the emotional expression. In the second task, participants were asked to label the emotional expressions on faces.

The study found that healthy controls were 16% slower in making judgments about physical features of the faces with positive or negative emotional expressions (happy, sad, fearful) relative to neutral faces an indication that they were distracted or affected by the emotional expressions on faces. The depressed participants showed no differences in response time to rating physical aspects of faces with emotional expressions or neutral faces. This suggests they were less sensitive to the effects of positive or negative emotional expressions.

In the second task, depressed participants had greater than 60% more difficulty with correctly labeling neutral faces, compared to healthy subjects. Depressed participants misread neutral expressions as happy, sad or fearful.

Dr. Mah noted that an impaired ability to read other people's emotional expressions can have social consequences and affect the quality of social interactions with others.

She also pointed out that these abnormalities in emotional processing seen in older depressed adults are distinct from those already reported in younger depressed adults who tend to perceive and process emotional stimuli more negatively overall when compared to healthy subjects.


Contact: Kelly Connelly
Baycrest Centre for Geriatric Care

Related medicine news :

1. Steady Weight Gain Boosts Late-Life Breast Cancer Risk
2. Untreated, Mild May Become Major Depression
3. Acupuncture found effective against depression during pregnancy
4. Depression Survey: Implications for Diverse Communities
5. Internet Addicts More Prone to Depression
6. Depression Survey: Implications for Diverse Communities
7. Most Antidepressants Miss Key Target of Clinical Depression
8. Attendance at Alcoholics Anonymous meetings may reduce depression symptoms
9. Stress, Anxiety Can Up Risk of Depression in Pregnancy
10. Largest academic-industry collaboration for drug discovery in depression and schizophrenia launched
11. Mastery of physical goals lessens disease-related depression and fatigue
Post Your Comments:
(Date:11/25/2015)... IL (PRWEB) , ... November 25, 2015 , ... ... to six decades of music, friendships, and learning in its 65th Anniversary Brillianteen ... held Dec. 5-6. , For 65 years, Brillianteen has been a ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Today, Mothers ... our nation’s roadways has dropped below 10,000 for the first time since 2011. In ... 2013. , According to data released by the National Highway Traffic Safety Administration (NHTSA), ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When ... that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In ... She developed the patent-pending RECOVERY BRA for added comfort and support. The bra ...
(Date:11/25/2015)... ... , ... Many people know of the common symptoms of low thyroid hormone ... But many people who find their cholesterol levels and weight are creeping up are ... if they don’t have any of the other symptoms. , Thyroid hormone plays a ...
(Date:11/25/2015)... ... November 25, 2015 , ... Students and parents have something to be thankful ... Create Real Impact awards. California Casualty is proud to support the contest ... distracted and reckless driving, the number one killer of young drivers. , Almost ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 - Will Also ... (CME) --> - Will ... Education (CME) --> - Will ... Continuing Medical Education (CME) Elsevier , ... services, will feature latest diagnostic imaging textbooks and decision support tools, ...
(Date:11/24/2015)... 25, 2015 The hope of ... failure of IVF cycles. After failure of over 15 ... had lost all hopes that she would be able to conceive ever. But finally optimism ... conceived after failure of over 15 IVF cycles. ... they decided to take one last attempt with Gaudium IVF Center in ...
(Date:11/24/2015)... 24, 2015  Array BioPharma Inc. (Nasdaq: ... Officer, Ron Squarer , will present at ... York.  The public is welcome to participate in ... BioPharma website.Event:Piper Jaffray Annual Healthcare ConferencePresenter:  , Ron ... 2015Time:1:30 p.m. Eastern Time Webcast: , ...
Breaking Medicine Technology: