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Why humans outlive apes
Date:1/26/2010

of ApoE4 in humans could be the result of the "antagonistic pleiotropy theory" of aging, in which genes selected to fight diseases in early life have adverse affects in later life.

"ApoeE may be a prototype for other genes that enabled the huge changes in human lifespan, as well as brain size, despite our very unape-like meat-rich diets," Finch said. "Drugs being developed to alter activities of apoE4 may also enhance lifespan of apoE4 carriers."

In spite of their genetic similarity to humans, chimpanzees and great apes have maximum lifespans that rarely exceed 50 years. Even in high-mortality modern hunter-forager populations, human life expectancy at birth is still twice that of wild chimpanzees.


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Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California
Source:Eurekalert

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