Navigation Links
Why good resolutions about taking up a physical activity can be hard to keep
Date:1/4/2013

ive ingredient of cannabis), and physical exercise. It was discovered ten years ago that physical exercise activated the endocannabinoid system in trained sportsmen, but its exact role remained a mystery for many years. Three years ago, the same research team in Bordeaux observed that when given the opportunity to use a running wheel, mutant mice lacking the CB1 cannabinoid receptor, which is the principal receptor of the endocannabinoid system in the brain, ran for a shorter time and over shorter distances than healthy mice. The research published in Biological Psychiatry this month seeks to understand how, where and why the lack of CB1 receptor reduces voluntary exercise performance (by 20 to 30%) in mice allowed access to a running wheel three hours per day.

The researchers used various lines of mutant mice for the CB1 receptor, together with pharmacological tools. They began by demonstrating that the CB1 receptor controlling running performance is located at the GABAergic nerve endings. They went on to show that the receptor is located in the ventral tegmental area of the brain (see diagram below), which is an area involved in motivational processes relating to reward, whether the reward is natural (food, sex) or associated with the consumption of psychoactive substances.

Based on the results of this study and earlier work, the Bordeaux team suggests the following neurobiological explanation: at the beginning and for the duration of physical exercise, the CB1 receptor is constantly simulated by the endocannabinoids, lipid molecules that naturally activate this receptor in response to pleasant stimuli (rewards) and unpleasant stimuli (stress). Endocannabinoid stimulation of the CB1 receptor during physical exercise inhibits the release of GABA, an inhibitory neurotransmitter that controls the activity of the dopamine neurons associated with the motivation and reward processes. This stimulation of the CB1 receptor "inhibits inhibition",
'/>"/>

Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Brain Spade Announces Site Launch is Now Set for January – New Year’s Resolutions Now Include Brain Health and Fitness
2. Boot Camp Classes for 2013 New Year’s Eve Resolutions!
3. The Spencer Institute Supports New Year’s Resolutions and Long-Term Health with Wellness Coach Certification
4. Time for New Year’s Resolutions, Add Better Tax Records to the List
5. Resolutions Don’t Work—But It’s NOT Because You Suck. How To Rock-It in 2013 with Vicki Dello Joio
6. EZ Wellness Extends HCG Sale to Aid New Years Resolutions For Weight Loss
7. VetDepot Encourages Owners to Include Pets in New Year’s Resolutions
8. New Years and Old Resolutions: Smart Vitamin Club Sees Ripple Effect of Health Resolutions
9. What can Hollywood teach us about our planet?
10. Stress about wifes breast cancer can harm a mans health
11. Concerns about MRSA for expectant mothers may be unfounded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... R.I. [Brown University] Autism is no stranger to ... East African nation is access to clinical services, including ... diagnostic measure, for example, validated for use in Swahili, ... new study, however, researchers at Brown University and the ... approach that they implemented at two sites in the ...
(Date:9/30/2014)... NJ (PRWEB) September 30, 2014 ... and wellness, is opening another new medical specialty practice ... IMA Cardiology will be located within the ... Ziad Abbud and Dr. Isaac Tawfik of American Heart ... N.J. The new practice will offer Integrated Medicine Alliance ...
(Date:9/30/2014)... 2014 Glycodrive , one of ... to help maximize lean, strong muscle growth with a ... of glucose has caught the attention of Shane Michaels, ... behind Glycodrive is to help the body use carbohydrates ... “Carbs are essential in the muscle-building process, and Glycodrive ...
(Date:9/30/2014)... VisitandCare.com reports that revenue ... up more than 79 percent in 2014, marking five ... reported total revenue tripled for its entirety of partnered ... strategy has allowed them to partner with plastic ... comfort and privacy — with state-of-the-art surgical atmospheres aimed ...
(Date:9/30/2014)... A group of Americans is headed to ... that, left unchecked, could create a catastrophic, global pandemic. No, ... Africa. John Rogers, the Executive Director the Eugene Bell Foundation ... a disease most think mankind conquered long ago: tuberculosis. , ... is on the comeback in several countries - what’s especially ...
Breaking Medicine News(10 mins):Health News:New diagnostic approach for autism in Tanzania 2Health News:New diagnostic approach for autism in Tanzania 3Health News:New diagnostic approach for autism in Tanzania 4Health News:Integrated Medicine Alliance Announces New Cardiology Practice 2Health News:Glycodrive Review Exposes Blue Star Nutraceutical’s Supplement for Leaner, Stronger Muscles 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2
... Use of estrogen alone did not increase lung cancer ... online August 13 in The Journal of the ... Health Initiative (WHI) trial, which consisted of several clinical ... previous hysterectomy taking combined estrogen plus progestin therapy had ...
... Reporter , FRIDAY, Aug. 13 (HealthDay News) -- When John D,Amato ... bottle of ibuprofen on the living room floor -- and one ... the pain-reliever container off the coffee table -- where D,Amato had ... pills. "My heart dropped through the floor," he said of ...
... influential medical centers to adopt electronic medical records helps ... Management Insights feature in the current issue of ... for Operations Research and the Management Sciences (INFORMS)., "Social ... Medical Records in U.S. Hospitals" is by Corey M. ...
... over the past 25 years has not translated into ... problems with study design and interpretation, as well as ... 12 in The Journal of the National Cancer ... defines a biomarker as "a characteristic that is objectively ...
... hereditary cancer syndrome may have a role in the regulation of ... the August 15 issue of Genes & Development , a ... called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls ... two major types of liver cells. "We found that ...
... HealthDay Reporter , THURSDAY, Aug. 12 (HealthDay News) ... new study finds that many heart patients aren,t all ... in Australia discovered that patients more often preferred boring ... pressure. "Fifty grams of dark chocolate [roughly one ...
Cached Medicine News:Health News:Estrogen not associated with lung cancer incidence and mortality among postmenopausal women 2Health News:Human Meds Are Pets' Biggest Poisoning Danger 2Health News:Human Meds Are Pets' Biggest Poisoning Danger 3Health News:Speed electronic medical record adoption via key medical centers, says Management Science 2Health News:The cancer biomarker conundrum: Too many false discoveries 2Health News:Merlin protein found to control liver stem cells, prevent tumor development 2Health News:Many Patients Say 'No' to Chocolate As Medicine 2Health News:Many Patients Say 'No' to Chocolate As Medicine 3
(Date:9/30/2014)... Sept. 30, 2014  HealthLoop® released an app version ... in iOS 8 and allows people to share medical ... harnesses native iOS technologies to enhance the HealthLoop experience ... connection with their doctors between visits. ... data they collect is exciting," says HealthLoop founder Dr. ...
(Date:9/30/2014)... , Sept. 30, 2014  Based on ... market, Frost & Sullivan recognizes Ventana Medical Systems, ... with the 2014 North American Frost & Sullivan ... quality practices along with a focus on innovation ... global leader in tissue-based cancer diagnostic solutions for ...
(Date:9/30/2014)... , Sept. 30, 2014  Georgia-Pacific Professional is ... and tissue for a wide range of away ... its product lines in healthcare, including hospitals, long-term ... Professional is introducing its healthcare products and solutions ... understands the importance of infection control in the ...
Breaking Medicine Technology:HealthLoop Integrates with Apple's HealthKit Enabling Patients to Share Health Data with Their Doctors Right from their iPhone 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 3Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 4Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 3
... Dec. 2, 2010 Palatin Technologies, Inc. (NYSE Amex: ... Amex LLC (the "Exchange"), advising Palatin that it is not ... standards under Section 1003 of the Exchange,s Company Guide. ... Palatin was not in compliance with Section 1003(a)(iii) of the ...
... Group is reporting a 35% surge in patients booking in ... the month before Christmas. Many patients are ... made before they return to work in the New Year. ... Breast enlargement , Nose Reshaping, and Liposuction. Lisa ...
Cached Medicine Technology:Palatin Technologies Receives Non-Compliance Letter from NYSE Amex 2Palatin Technologies Receives Non-Compliance Letter from NYSE Amex 3The Harley Medical Group Sees an Uptake in Surgery Bookings for Christmas 2
Low temp, micro fine tip, patented Aaron RAM cauteries....
Aaron 2250 is a multipurpose electrosurgical generator with monoploar and bi-polar functions....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Medicine Products: