Navigation Links
Why dopamine freezes parkinson patients and drives drug addicts
Date:8/8/2008

became stronger and more powerful. At the same time, dopamine weakened the cortical connections in the "stop" circuit.

"This could be what underlies addiction," Surmeier said. "Dopamine released by drugs leads to abnormal strengthening of the cortical synapses driving the striatal 'go' circuits, while weakening synapses at opposing 'stop' circuits. As a result, when events associated with drug taking where you took the drug, what you were feeling occur, there is an uncontrollable drive to go and seek drugs."

"All of our actions in a healthy brain are balanced by the urge to do something and the urge to stop," Surmeier said. "Our work suggests that it is not just the strengthening of the brain circuits helping select actions that is critical to dopamine's effects, it is the weakening of the connections that enable us to stop as well. "

In the second part of the experiment, scientists created an animal model of Parkinson's disease by killing dopamine neurons. Then they looked at what happened when they simulated cortical commands to move. The result: the connections in the "stop" circuit were strengthened, and the connections in the "go" circuit were weakened.

"The study illuminates why Parkinson's patients have trouble performing everyday tasks like reaching across a table to pick up a glass of water when they are thirsty," Surmeier said.

Surmeier explained the phenomenon using the analogy of a car. "Our study suggests that the inability to move in Parkinson's disease is not a passive process like a car running out of gas," he said. "Rather, the car doesn't' move because your foot is jammed down on the brake. Dopamine normally helps you adjust the pressure on the brake and gas pedals. It helps you learn that when you see a red light at an intersection, you brake and when the green light comes on, you take your foot off the brake and depress the gas pedal to go. Parkinson's disease patients, who have lost the neurons
'/>"/>

Contact: Marla Paul
marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Food restriction increases dopamine receptor levels in obese rats
2. Antidepressants Can Increase Depression, Impulsivity and Suicide Risk by Decreasing Dopamine
3. Identification of dopamine mother cells could lead to future Parkinsons treatments
4. Fear that freezes the blood in your veins
5. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
6. Gene Mutation Linked to Parkinsons Disease
7. Parkinsons Linked to Risk of Alzheimers
8. XShares Supports Parkinsons Disease Foundation 50th Anniversary Educational Symposium
9. Parkinsons Institute research shows that nicotine reduces levodopa-induced dyskinesias
10. NSAIDs Protect Against Parkinsons Disease
11. Ceregene Completes Enrollment of Phase 2 Clinical Trial for Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... (PRWEB) November 24, 2014 Residents of ... stage in this year’s SENIORS GOT TALENT, an annual ... , From piano players to classic crooners, to seniors ... that older adults are indeed living young. , “SENIORS ... because there’s a cash prize, has always been about ...
(Date:11/24/2014)... November 24, 2014 The Holiday Inn ... Family and Children's Association to donate various ... shampoo, mouthwash and other such items.The Association's program is ... home bound, living in nursing homes, assisted living facilities ... enhance the well being of seniors throughout the Long ...
(Date:11/24/2014)... SafeHandles™ announced that they will be ... Begley Jr, airing via Discovery Channel. Dates and show ... passive, non-invasive, replaceable, and affordable germ protective device. This ... sleeves and adhesives to promote hand hygiene in high ... of SafeHandles is the desire to make a positive ...
(Date:11/24/2014)... November 24, 2014 "My friend was ... trying to cross the street in his motorized wheelchair," ... saw him. I came up with this idea so ... night." , He developed the Safety Lites to make ... low-lighting conditions. The device ensures that motorists can see ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 The ... Market 2006 to 2020 - Asia-Pacific” provides quantitative ... devices market segments: minimally invasive body contouring devices, ... The analysis includes market size data by revenue ... the following countries: China, Japan, South Korea, Australia ...
Breaking Medicine News(10 mins):Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 3Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4
... researchers will lead a $10.25 million effort to study ... need for dialysis. The five-year project supports research ... that, though rare, generates an enormous individual and societal ... to nearly 12 percent of cases of kidney failure, ...
... , , , ... by wearing a purple LFA wristband until there is an FDA-approved medication ... It,s been 50 years since the U.S. Food and Drug Administration (FDA) ... President! To highlight the need for safer, more tolerable, and effective medications, ...
... NEW YORK, Sept. 22 The Global Network ... partnership with the Miss Universe Organization aimed at educating millions ... control and eliminate neglected tropical diseases across the region. ... time in their home countries participating in education and mass ...
... , , SAN MARCOS, Calif., ... NAII ), a leading formulator, manufacturer and marketer of customized nutritional ... per diluted share on net sales from continuing operations of $73.9 ... fiscal 2009 results include a net loss from discontinued operations of ...
... , , NEW YORK, Sept. 22 ... of specialty insurance and insurance-related products and services, will release 2009 third ... The news release will be available on Assurant,s Web site at ... broadcast its 2009 third quarter conference call at 9:00 a.m. ET on ...
... ELM GROVE, Wis., Sept. 22 A free ... Factor in HAI , is being sponsored by Compirion Healthcare Solutions, ... Wisconsin. Dates and times, along with registration information, can be found ... webinar are the main causes of non-compliance with hospital hand-washing ...
Cached Medicine News:Health News:Kidney advocates launch $10.25 million effort to examine cause of kidney failure 2Health News:The Lupus Foundation of America, Inc. Asks Supporters to Band Together for Lupus(SM) 2Health News:Miss Universe Organization, Global Network for Neglected Tropical Diseases Join Forces to Eliminate Neglected Tropical Diseases in the Americas 2Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 2Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 3Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 4Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 5Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 6Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 7Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 8Health News:Assurant to Announce 2009 Third Quarter Results Oct. 28, 2009 and Host Webcast Conference Call Oct. 29 2Health News:Free Webinar on Helping Hospitals Control Healthcare-Associated Infections by Improving Hand Hygiene 2Health News:Free Webinar on Helping Hospitals Control Healthcare-Associated Infections by Improving Hand Hygiene 3
(Date:11/24/2014)... Pharmaceuticals, Inc. (NASDAQ: ARNA ) announced today that the ... at the Piper Jaffray 26 th Annual Healthcare Conference ... (5:30 a.m. Pacific Time), at The New York Palace Hotel ... live audio webcast of the presentation will be available under ... . A replay of the presentation will be available for ...
(Date:11/24/2014)... 24, 2014  Marta Rendon, MD, founder of the Rendon ... , FL and international key opinion leader in dermatology, was ... the United States to attend the international Aesthetic ... . Here, at this gathering of over 600 physicians ... facial plastic surgery experts from Asia ...
(Date:11/24/2014)... 24, 2014  Surgical Theater, LLC, announced today that ... th opening of Europe,s ... "C. Besta." The SuRgical Planner (SRP) and the Surgical ... event for their 3D navigation and augmented reality capabilities ... , Professor and Chair, Department of Neurosurgery at Mount ...
Breaking Medicine Technology:Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3
... Sciences International, Inc. (Nasdaq: BDSI ) announced ... Officer of BDSI, will present at the ROTH Capital ... Ritz-Carlton, Laguna Niguel in Dana Point, California.  The presentation ... Pacific Time.   (Logo: http://photos.prnewswire.com/prnh/20110217/CL49801LOGO) ...
... Pharmacy (Pink Sheets: APHY ), a leading specialty ... of chronic pain, is pleased to announce that the accounting ... Pharmacy,s consolidated financial statements for the years ended December 31, ... 31, 2010 is in process which is expected to be ...
Cached Medicine Technology:BioDelivery Sciences to Present at the 23rd Annual ROTH OC Growth Stock Conference 2BioDelivery Sciences to Present at the 23rd Annual ROTH OC Growth Stock Conference 3Assured Pharmacy Completes Audit of 2008-2009 Financial Statements 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: