Navigation Links
Why dopamine freezes parkinson patients and drives drug addicts
Date:8/8/2008

CHICAGO -- Parkinson's disease and drug addiction are polar opposite diseases, but both depend upon dopamine in the brain. Parkinson's patients don't have enough of it; drug addicts get too much of it. Although the importance of dopamine in these disorders has been well known, the way it works has been a mystery.

New research from Northwestern University's Feinberg School of Medicine has revealed that dopamine strengthens and weakens the two primary circuits in the brain that control our behavior. This provides new insight into why a flood of dopamine can lead to compulsive, addictive behavior and too little dopamaine can leave Parkinson's patients frozen and unable to move.

"The study shows how dopamine shapes the two main circuits of the brain that control how we choose to act and what happens in these disease states, " said D. James Surmeier, lead author and the Nathan Smith Davis Professor and chair of physiology at the Feinberg School. The paper is published in the August 8 issue of the journal Science.

These two main brain circuits help us decide whether to act out a desire or not. For example, do you get off the couch and drive to the store for an icy six-pack of beer on a hot summer night, or just lay on the couch?

One circuit is a "stop" circuit that prevents you from acting on a desire; the other is a "go" circuit that provokes you to action. These circuits are located in the striatum, the region of the brain that translates thoughts into actions.

In the study, researchers examined the strength of synapses connecting the cerebral cortex, the region of the brain involved in perceptions, feelings and thought, to the striatum, home of the stop and go circuits that select or prevent action.

Scientists electrically activated the cortical fibers to simulate movement commands and boosted the natural level of dopamine. What happened next surprised them. The cortical synapses connecting to the "go" circuit
'/>"/>

Contact: Marla Paul
marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Food restriction increases dopamine receptor levels in obese rats
2. Antidepressants Can Increase Depression, Impulsivity and Suicide Risk by Decreasing Dopamine
3. Identification of dopamine mother cells could lead to future Parkinsons treatments
4. Fear that freezes the blood in your veins
5. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
6. Gene Mutation Linked to Parkinsons Disease
7. Parkinsons Linked to Risk of Alzheimers
8. XShares Supports Parkinsons Disease Foundation 50th Anniversary Educational Symposium
9. Parkinsons Institute research shows that nicotine reduces levodopa-induced dyskinesias
10. NSAIDs Protect Against Parkinsons Disease
11. Ceregene Completes Enrollment of Phase 2 Clinical Trial for Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Akron, OH (PRWEB) October 20, 2014 ... new Assisted Living Center on Oct. 14. The $11 ... amenities and services, and a cooked-to-order kitchen with full-service ... forward Akron’s premier choice for first class Assisted Living ... groundbreaking. “Our residents deserve the highest quality of care ...
(Date:10/20/2014)... National Teen Driver Safety Week is October 19-25, 2014 and ... AAP, http://www.ohioaap.org ) is joining the National Highway Traffic ... talk to their teens and always set the rules before ... leading cause of death for U.S. teens. In 2012, there ... (42%) of those teen drivers were killed in crashes. While ...
(Date:10/20/2014)... It’s hard to imagine what it’s like ... children around the world, it’s a reality. And while new ... are forced to walk barefoot on rocky terrain or sewage-lined ... with their friends. , Buckner International's Shoes for ... in October to encourage support for Air1 and while ...
(Date:10/20/2014)... Spring, Maryland, USA (PRWEB) October 20, 2014 ... or to track interventions? Here comes a wonderful app ... mobile app development company helped its client ... Intervention more efficiently. The app is designed for iOS ... and iPod touch. This app is optimized for iPhone ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Recently, BambooIndustry.com, ... has unveiled its new range of bamboo deckings ... for these natural items; they are now available at ... most people, it is hard to overstate the significance ... of attention to online services. The company’s workers are ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2
... a national leader in accounts receivable management, and collection services to ... created position of Chief Operating Officer (COO). , ... ... leader, MDS ( www.meddatsys.com ), has announced Eugene (Gene) Schneider to ...
... cause irreversible damage, doctors say , , WEDNESDAY, March 18 (HealthDay ... death Wednesday of actress Natasha Richardson, reports that she suffered ... Canadian ski slope on Tuesday have many people wondering how ... of the most lauded acting families in Great Britain; her ...
... "The White House made the correct decision ... Veterans Affairs to have military veterans, personal insurance ... said VAdm. Norb Ryan, Jr., USN-Ret., president of ... said he advised President Obama that "pursuing this ...
... cents donated for every person that playsPHOENIX, March 18 ... home products, is kicking off The Candle Game to benefit ... the free online game, Gold Canyon will donate 10 cents ... Game can be played online at http://thecandlegame.com and ...
... was 98% for Kit-positive GIST patients taking Gleevec vs. ... patients experienced recurrence of GIST(2) within a median of ... treatment in the US and Switzerland indicated to reduce ... is underway in the EU(4) EAST HANOVER, N.J., March ...
... March 18 Speaker Nancy Pelosi announced this afternoon ... that could have forced veterans to use their private insurance ... Pelosi made the announcement at a meeting she and House ... veterans, service organizations, who greeted the news with a standing ...
Cached Medicine News:Health News:Medical Data Systems, Inc. (MDS) Announces New Chief Operating Officer (COO) 2Health News:Medical Data Systems, Inc. (MDS) Announces New Chief Operating Officer (COO) 3Health News:Brain Hemorrhage Might Explain Natasha Richardson's Death 2Health News:Brain Hemorrhage Might Explain Natasha Richardson's Death 3Health News:White House Makes Correct Decision On Veterans Insurance Proposal 2Health News:Gold Canyon Ignites Hope With Online Charity Candle Game 2Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 2Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 3Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 4Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 5Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 6Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 7Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 8Health News:Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports 9Health News:Pelosi: Administration Will Not Force Veterans to Use Private Insurance to Pay for Treatment of Combat-Related Injuries 2
(Date:10/19/2014)... MELVILLE, N.Y. , Oct. 19, 2014  Henry ... largest provider of health care products and services to ... that it has invested in Iwase Dental Supply, Inc., ... equipment in Japan.  The transaction marks Henry Schein,s entrance into ... largest dental market, and increases to 28 the ...
(Date:10/17/2014)... HILL, N.C. , Oct. 17, 2014 /PRNewswire/ ... landscape, the Medical Affairs function has come across ... allocating resources efficiently and managing globalization.  ... Best Practices, LLC is dedicated to providing benchmarking ... The Medical Affairs Consortium is a service composed ...
(Date:10/17/2014)... 17, 2014  Amgen (NASDAQ: AMGN ) ... , M.D., president of Gladstone Institutes and Gladstone,s Robert ... "We are pleased to welcome Dr. Sandy ... A. Bradway , chairman and chief executive officer of ... medicine and his direct experience in our industry will ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Early Key Findings from the Medical Affairs Consortium Research 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
... Inc . (NYSE: CRY ), a leading tissue ... surgery, announced today its results for the third quarter and ... increased 4 percent to a record $29.7 million compared to ... the first nine months increased 2 percent to a record ...
... 2011 The Breast journal published new ... National University College of Medicine in Korea that shows ... tumor detection compared to whole-body PET/CT when using both ... particularly striking and significant for smaller-sized tumors (less than ...
Cached Medicine Technology:CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 2CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 3CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 4CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 5CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 6CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 7CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 8CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 9CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 10CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 11CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 12CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 13CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 14CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 15CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 16CryoLife Reports Financial Results for the Third Quarter and First Nine Months of 2011 17Published Data Demonstrates Positron Emission Mammography Has Higher Sensitivity Than PET/CT 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: