Navigation Links
Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?
Date:3/3/2009

Resent studies reported that aspirin inhibited the growth of H. pylori in a dose-dependent manner and significantly affected the activity of virulence factors of H. pylori. In addition, aspirin increased the susceptibility of H. pylori to antimicrlbials including metronidazole, clarithromycin and amoxicillin. However, the mechanisms remained unknown.

A research team led by Prof. Wang from Peking University First Hospital of China addressed this issue and their results will be published on February 28, 2009 in the World Journal of Gastroenterology.

H. pylori reference strain 26695 and two metronidazole-resistant isolates of H. pylori were included in this study. The effect of aspirin on the permeability of the outer membrane of H. pylori was determined using [7-3H] tetracycline. The effects of aspirin on the expression of OMPs of H. pylori were also determined. Taqman-based real-time quantitative PCR was used to analyze the influence of aspirin on the expression of the related OMPs genes.

They found that the mutations in rdxA gene did not change in metronidazole resistant isolates treated with aspirin. The radioactivity of H. pylori increased when treated with aspirin, indicating that aspirin improved the permeability of the outer membrane of H. pylori. However, the expression of two OMP bands between 55 kDa and 72 kDa altered in the presence of aspirin. The expression of the mRNA of hopA, hopB, hopC, hopD, hopE and hefA, hefB, hefC of H. pylori did not change when treated with aspirin.

Their results indicated that although aspirin increases the susceptibility of H. pylori to metronidazole, it has no effect on the mutations of rdxA gene of H. pylori. Aspirin increases endocellular concentrations of antimicrobials and probably by altering the expression of the outer membrane proteins (OMP) of H. pylori. Their study will help understand the mechanisms of the resistance of H. pylori to antibiotics more intensively and discover a more effective eradication regimen in clinical practice.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. What is the most effective therapy for low-dose aspirin induced peptic ulcer?
2. Long-Term Aspirin Use Seems to Protect Against Colorectal Lesions
3. Human Body May Make Its Own Aspirin
4. Men who take aspirin have significantly lower PSA levels
5. Type 2 Diabetics Studied in Low-Dose Aspirin Trial
6. Aspirin Doesnt Guard Diabetics Against Heart Disease
7. Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
8. Bayer Marketing Two Unapproved Aspirin Products: FDA
9. New CHARISMA Outcome Study Results Validate Aspirin Effect
10. Breakthrough Testing for Patients on Aspirin Therapy for Preventing Heart Attacks
11. Statement From Bayer(R) Aspirin Regarding the American Medical Associations New Aspirin Policy Resolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... ... institution’s inaugural K-20 Education Summit to be held March 23-25, 2017 in Tampa, ... Jan. 25, 2017. , The keynote speakers include Dr. Michelle R. Weise, executive ...
(Date:1/23/2017)... ... ... Wooden and plastic balance boards have been around since at least the 1950s and are ... the first and only balance board to use a patent-pending design featuring high-pressure inflation technology ... time as well as skill-level adjustable for all ages and abilities. The board can ...
(Date:1/23/2017)... SC (PRWEB) , ... January 23, 2017 , ... ... is the premiere organization in North America for the scientific development, healthcare training ... 2017 Annual Scientific Session, and its 2017 AAT Member Certification Qualification Courses for ...
(Date:1/23/2017)... ... January 23, 2017 , ... Moisture ... choosing the right method is paramount to success. Selecting an inappropriate measurement method ... where multiple persons use the same equipment. Rare or expensive substances are wasted ...
(Date:1/23/2017)... ... January 23, 2017 , ... Old School Labs™, makers ... Mr. Olympia Classic Physique bodybuilder Breon Ansley to its growing team of brand ambassadors. ... bodybuilder in 2012 and in less than a year was able to turn professional, ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... 2017 NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical collaboration agreement with the Children,s Hospital of ... M.D., a US key opinion leader in the mitochondrial medicine ... ... from NeuroVive,s research program, NVP015, in certain experimental disease models. ...
(Date:1/21/2017)... Research and Markets has announced the addition of ... Test (Tumor, Clinical Chemistry, Microbiology, Esoteric), By Type of Lab ... Cancer, HIV/AIDS etc.), Forecast to 2022" report to their ... ... especially clinical lab testing, which has evolved as a major ...
(Date:1/21/2017)... CAMBRIDGE, Mass. , Jan. 20, 2017 ... the Keystone Symposia Conference, "PI3K Pathways in ... Pharmaceuticals, Inc. (NASDAQ: INFI ... oral immuno-oncology development candidate that selectively inhibits ... is able to help overcome resistance to ...
Breaking Medicine Technology: