Navigation Links
Why do some diabetics escape complications?
Date:1/21/2011

"The majority of diabetics will over time develop severe or fatal complications, but 10󈝻 per cent never do. They are the ones we are interested in in the PROLONG study", explains Valeriya Lyssenko, who along with Peter Nilsson, both from Lund University Diabetes Centre, leads the PROLONG study.

Stiff sugary arteries: Despite decades of intensive research on diabetes complications, the fundamental mechanisms are not yet fully known. Neither is it possible to prevent or treat the damage to the blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher for diabetics than for non-diabetics. The small blood vessels are also damaged. After only ten years with diabetes, 70 per cent of patients will have some form of kidney damage that may progress to kidney failure. As many suffer from eye complications some will develop severe visual impairment and two per cent will become blind.

"The blood vessels and other organs of the body become sugar coated and stiff. It is reminiscent of premature biological ageing", says Peter Nilsson.

Half of the veterans: Perhaps nature itself can answer the question of why some patients are protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had diabetes for more than 30 years; of these, 1 600 have had it for over 50 years.

"About half of these diabetic veterans do not have major complications. Two thirds of those who have had diabetes for more than 50 years have escaped complications. Clearly they are different and we want to find out what it is that protects them", says Valeriya Lyssenko.

Greatest risk passed after 30 years: The PROLONG study is starting now in Skne with a pilot study of patients with diabetes duration of more than 30 years. At a later stage patients will be recruited from all hospitals and health care centres in Sweden. They will be compared with diabetics who have already developed severe complications despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes for such a long time without developing complications is unlikely to do so later in life.

Copying nature's protective mechanisms: Participants in the PROLONG study will answer questions about their lifestyle and about diseases they, or their closest relatives, may have. Various blood samples, including genetic tests, will be analysed, and close relatives of the participants will also be invited to take part in the study.

"If we can identify factors protecting these veterans from devastating complications, then it might be possible to develop drugs that can do the same thing", says Valeriya Lyssenko.

"I have dreamt of performing a study like this for a long time", adds Peter Nilsson.

PROLONG stands for PROtective genes in diabetes and LONGevity

Major diabetic complications include kidney disease (nephropathy), eye damage (retinopathy), heart attacks and stroke.


'/>"/>
Contact: Valeriya Lyssenko
Valeriya.Lyssenko@med.lu.se
46-730-427-352
Lund University
Source:Eurekalert

Related medicine news :

1. MicroRNAs could increase the risk of amputation in diabetics
2. Adding Surgery to Meds May Help Diabetics With Heart Disease
3. Drop Seen in Rate of End-Stage Kidney Disease in Diabetics
4. A dry AMD treatment?; some long-term diabetics escape PDR
5. Eye Disease Affects Nearly One in Three Diabetics
6. Diabetics Urged to Confer With Their Doctor About Avandia Use
7. Tight Blood Pressure Control Doesnt Help All Diabetics: Study
8. Tight Blood Sugar Control in Older Diabetics May Not Reduce Heart Risk
9. Many Diabetics Unaware of Hot Weather Hazards
10. Glucose Tattoo Could Track Blood Sugar Levels for Diabetics
11. Experts Advise At-Risk Diabetics to Begin Daily Aspirin Later
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned ... Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness ... on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
(Date:10/12/2017)... ... 2017 , ... Farm Forward joins Bon Appétit ... institutions in announcing the launch of the Leadership Circle , a program ... raised for food. , Founding members of the Leadership Circle also include Airbnb’s ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Caris Life Sciences ® , a leading innovator in ... medicine, today announced that St. Jude Medical Center,s Crosson ... as its 17 th member. Through participation with ... Institute will help develop standards of care and best ... cancer treatment more precise and effective. ...
(Date:10/10/2017)... Oct. 10, 2017  NDS received FDA 510(k) clearance in May ... battery-powered display stand specifically designed for endoscopy environments. An innovative secondary ... a clinical solution to support the improvement of patient outcomes, procedural ... ... ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: