Navigation Links
Why do infants get sick so often?
Date:8/7/2012

ANN ARBOR, Mich. Researchers at the University of Michigan Health System are helping to quell parents' worry about why infants seem to get sick so often.

It's been believed that, like walking and talking, fighting viral infections is something children will develop when they get older. But a U-M study suggests the natural ability to fight infection is there early on.

Scientists learned key cell signals inhibit the growth of essential immune cells early in life. Blocking this signaling could lead to improving an infant's response to infection, according to the study published online ahead of print in Nature Immunity.

"What happens at early age is that natural killer cells, like many other immune cells, do not complete their functional maturation until adulthood," says study senior author Yasmina Laouar, Ph.D., assistant professor in the U-M Department of Microbiology and Immunology.

"During this time we are left with an immature immune system that cannot protect us against infections, the reason why newborns and infants are more prone to infection," she says.

There is a large gap in understanding infant immunity, specifically why the natural killer cell responses are deficient. The study by immunologists at the U-M demonstrates the role of a cell called transforming growth factor beta that can explain why.

The study showed the production of natural killer cells is controlled by TGF-β, which is produced in the bone marrow. In infant mice, the maturation of natural killer cells progressed faster in the absence of TGF-β signaling.

By adulthood, mice had 10 times more mature natural killer cells if TGF-β signaling was blocked.

"Our overall goal was to determine the factors that constraint the production and maturation of natural killer cells early in life," says Laouar. "To our surprise, we discovered that natural killer cells can complete maturation as early as 10 days of age if TGF-β signaling is blocked."

Authors say it's tempting to propose the functional inactivation TGF-β signaling as a strategy to reverse the deficit of natural killer cells early in life. Additional testing will be required.


'/>"/>
Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Depressed moms behavior may play role in infants sleep problems
2. Research shows efficacy of treatment model developed at Women & Infants
3. Low-Income Mothers May Overfeed Their Infants
4. Gut flora affects maturation of B cells in infants
5. Phthalates in PVC floors taken up by the body in infants
6. Disease that stunts infants growth traced to same gene that makes kids grow too fast
7. Infants cant distinguish between large and small groups
8. Women & Infants to participate in national effort to increase breastfeeding rates
9. Keep Infants Out of Sun and Heat, Experts Warn
10. Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
11. Scientists ID New Gene Linked to Vision Loss in Infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... , ... April 28, 2017 , ... ... expanded distribution of the GlycoMark test throughout the Northeast U.S. , GlycoMark ... patients with diabetes. The GlycoMark test provides a clinically proven one- to two-week ...
(Date:4/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... election process has been in place since the RBMA was founded in 1968 with ... succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer ...
(Date:4/28/2017)... ... 28, 2017 , ... The Texas Cord Blood Bank (TCBB), a program of ... team at Women’s Hospital at Renaissance in Edinburg for their outstanding efforts in collecting ... decide to donate. , “Women’s Hospital at Renaissance has been a collection partner ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... People are ... older people. “Wearing a hearing aid doesn’t have the stigma it had when great-grandpa ... Hearing Associates of Greater Boston, in a NALA North American Speaker Series ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at ... ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled in ... activity and sleep monitoring solutions for the global scientific community. The company’s new ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... Halo Labs announces the launch of a novel low ... Horizon at PEGS 2017 in Boston ... visible particulate matter in biopharmaceutical samples to enable for ... candidate selection and pre-formulation. Halo Labs is ... Elion Labs for system validation. "We are very ...
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... , April 20, 2017 Research ... Pharmacogenomics Market Size, Market Share, Application Analysis, Regional Outlook, Growth ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 ... Mn by 2024, expanding at a CAGR of 5.6% from ...
Breaking Medicine Technology: