Navigation Links
Why do infants get sick so often?
Date:8/7/2012

ANN ARBOR, Mich. Researchers at the University of Michigan Health System are helping to quell parents' worry about why infants seem to get sick so often.

It's been believed that, like walking and talking, fighting viral infections is something children will develop when they get older. But a U-M study suggests the natural ability to fight infection is there early on.

Scientists learned key cell signals inhibit the growth of essential immune cells early in life. Blocking this signaling could lead to improving an infant's response to infection, according to the study published online ahead of print in Nature Immunity.

"What happens at early age is that natural killer cells, like many other immune cells, do not complete their functional maturation until adulthood," says study senior author Yasmina Laouar, Ph.D., assistant professor in the U-M Department of Microbiology and Immunology.

"During this time we are left with an immature immune system that cannot protect us against infections, the reason why newborns and infants are more prone to infection," she says.

There is a large gap in understanding infant immunity, specifically why the natural killer cell responses are deficient. The study by immunologists at the U-M demonstrates the role of a cell called transforming growth factor beta that can explain why.

The study showed the production of natural killer cells is controlled by TGF-β, which is produced in the bone marrow. In infant mice, the maturation of natural killer cells progressed faster in the absence of TGF-β signaling.

By adulthood, mice had 10 times more mature natural killer cells if TGF-β signaling was blocked.

"Our overall goal was to determine the factors that constraint the production and maturation of natural killer cells early in life," says Laouar. "To our surprise, we discovered that natural killer cells can complete maturation as early as 10
'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Depressed moms behavior may play role in infants sleep problems
2. Research shows efficacy of treatment model developed at Women & Infants
3. Low-Income Mothers May Overfeed Their Infants
4. Gut flora affects maturation of B cells in infants
5. Phthalates in PVC floors taken up by the body in infants
6. Disease that stunts infants growth traced to same gene that makes kids grow too fast
7. Infants cant distinguish between large and small groups
8. Women & Infants to participate in national effort to increase breastfeeding rates
9. Keep Infants Out of Sun and Heat, Experts Warn
10. Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
11. Scientists ID New Gene Linked to Vision Loss in Infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 2014 The establishment and creation ... been one of the main strategies of the ... positive impact around the world. , Architecturally stellar ... trained executives and trainers deliver L. Ron Hubbard's ... Vital statistics demonstrate that significant reduction in crime, ...
(Date:8/30/2014)... 30, 2014 After offering hyperbaric ... for the past several years, Dr. Roy Schmidt ... have announced a scholarship program for veterans who ... a meeting held this summer to discuss veterans’ ... reporters have shed light on the large number ...
(Date:8/30/2014)... 2014 Acne is a common problem millions of ... nothing more than a daily nuisance, for some, it can have ... acne can even lead to dramatic mood swings and depression. ... to clear up their skin. In some cases, that can make ... trial and error, those on a quest for clearer skin can ...
(Date:8/30/2014)... 2014 Market Research Report on ... a professional and in-depth market survey on Global ... reviews the basic information of Cell Disruptor including ... then explores global and China’s top manufacturers of ... value, and market share etc. The report further ...
(Date:8/30/2014)... Seniors Guide, the comprehensive guide to all things senior, ... Disease, Dementia, and Memory Loss . , Country singer Glen ... with the Alzheimer’s, inspired Seniors Guide writers to review the ... movie, out on October 14, 2014, shows a glimpse of ... disease – which inspires a final tour from the musician ...
Breaking Medicine News(10 mins):Health News:Cradle of Aviation Museum Opens Its Doors to Long Island Scientologists 2Health News:Tennessee Hyperbaric Center Offering HBOT Scholarships to Veterans 2Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 2Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 3Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 4Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2
... As the most trusted and,accessible health care ... health and make more than 80 million recommendations ... will follow these,recommendations. In fact, a recent survey, ... Patient Information and Education, found that,most Americans (80%) ...
... Commonly Prescribed Generic Drugs will be priced at $4 for a ... 30-day supply and $10 for a 90-day supply, ... its Stater Bros. Super Rx Pharmacy locations will begin,offering generic drugs ... the most commonly prescribed generic drugs will now be,available for the ...
... half had experienced it before or during college, survey ... between partners, friends and acquaintances is common before and ... 910 undergraduates aged 17 to 22 (57.1 percent female) ... , Among the findings: , , 407 (44.7 ...
... Inc.,(Nasdaq: THRM ), a leader in non-invasive ... it will present at the Collins Stewart LLC,Fourth ... in New York,City. Stephen J. Fanning, Chairman, President ... Officer, will review the Company,s,business strategy, historical financial ...
... In a New York City metro-area first, a 93-year-old ... at NewYork-Presbyterian Hospital, the only center on the Eastern ... new stent graft was implanted under an FDA-approved clinical ... a complex form of abdominal aortic aneurysms in which ...
... Seventh Annual Joint Conference With Centro Medical Paitilla to Focus on ... ... of physicians from Cleveland,Clinic will travel to Panama in mid July to ... Meeting. The,subject of this year,s conference is the Central Nervous System: Benign ...
Cached Medicine News:Health News:Stater Bros. Super Rx Pharmacy(SM) Now Offering $4 Generic Prescription Drugs 2Health News:Relationship Violence Common Among College Students 2Health News:NYC first: Complex aneurysm treated using new fenestrated endograft stent 2Health News:Cleveland Clinic Physicians to Present at Medical Conference in Panama, July 11-12 2Health News:Cleveland Clinic Physicians to Present at Medical Conference in Panama, July 11-12 3
(Date:8/30/2014)...   Royal Philips  (NYSE: PHG, AEX: PHIA) today ... ultrasound system designed to enable global hospitals and health ... and cost pressures. Making its debut at the  European ... Barcelona this week, Affiniti provides innovative technology ... resources deliver high quality patient care. ...
(Date:8/29/2014)... /PRNewswire-iReach/ -- Market Research Report on Global and ... professional and in-depth market survey on Global ... report firstly reviews the basic information of X-Ray ... technology. The report then explores global and China,s ... product specification, capacity, Production value, and market share ...
(Date:8/29/2014)... 2014  Chuma Holdings, Inc. (OTCBB:CHUM) (the "Company"), ... support services for the lawfully organized cannabis industry, ... approved the Company,s name and symbol change request. ... be known as Chuma Holdings, Inc. ... merger with the Company,s wholly-owned subsidiary, Chuma Holdings, ...
Breaking Medicine Technology:Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 2Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 3Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5CannaMed Announces Name Change and Trading Symbol Change 2CannaMed Announces Name Change and Trading Symbol Change 3
... Open-label Extension of Phase II Study Demonstrates ... Mass., June 12, 2007 /PRNewswire-FirstCall/ --,Indevus Pharmaceuticals, ... Phase II EXPRESS trial for pagoclone in ... the 47th annual,meeting of the New Clinical ...
... activity reported against CTCL, PTCL and Ovarian ... -- CuraGen,Corporation , a clinical-stage biopharmaceutical company ... the clinical development,program for belinostat, a histone ... clinical activity of belinostat,against cutaneous T-cell lymphoma ...
Cached Medicine Technology:Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 2Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 3Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 4Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 5Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 6Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 7Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 8Indevus Announces Presentation of Pagoclone Data at 47th Annual New,Clinical Drug Evaluation Unit Meeting 9CuraGen Presents Update on Clinical Development Program for,Belinostat 2CuraGen Presents Update on Clinical Development Program for,Belinostat 3CuraGen Presents Update on Clinical Development Program for,Belinostat 4CuraGen Presents Update on Clinical Development Program for,Belinostat 5CuraGen Presents Update on Clinical Development Program for,Belinostat 6CuraGen Presents Update on Clinical Development Program for,Belinostat 7CuraGen Presents Update on Clinical Development Program for,Belinostat 8
... resistance of stainless steel with the ... offers an electro-polished copper-alloy-stainless interior that ... sterile environment promotes the integrity of ... safety of laboratory staff. This exclusive ...
DH Autoflow Single Chamber Stackable Air-Jacketed CO2 Incubator...
US Autoflow Single Chamber Stackable Water-Jacketed CO2 Inc.w/ Humidity Display and Control...
... from commonly used protein expression procedures using ... medium, contains two media, EXPANSION BROTH (EB) ... E. coli cells are grown in EB, ... is almost completely repressed. For high level ...
Medicine Products: