Navigation Links
Why chemotherapy fails
Date:5/29/2012

The fight against cancer is not won in a single battle: Long after a cancer has been beaten into remission, it can return. The reason for this is under debate, and much is unclear. New research led by Weizmann Institute scientists shows that, at least for one type of blood cancer, the source of cancer recurrence is in a set of cells that do not proliferate as quickly as regular cancer cells, and thus able to survive chemotherapy. The findings, which appeared today in the journal Blood, have some important implications for the future of the war on cancer.

Cancer involves a breakdown in the mechanism that regulates the pace of cell division. When this happens, cells divide rapidly, leading to unchecked growth that overruns the body. The most common chemotherapy drugs are those which specifically attack cells that are undergoing rapid division, and these, indeed, often destroy all the cancer and cure the patient.

But there are also quite a few leukemia patients who go through chemotherapy only to have the cancer return. Why does this happen? Several explanations have been proposed. One is that the chemotherapy does not kill every last cancer cell, leaving a few to continue dividing out of control until the disease returns in full force. A second explanation proposes that chemotherapy does get all the regular cancer cells, but there is another type of cancer cell that hides in the body. As opposed to the rapidly dividing majority of cancer cells, these undergo slow division, enabling them to evade the chemotherapy drugs. These insidious cells can give rise to new rapidly-dividing cancer cells, which is why they are known as "cancer stem cells."

Which explanation is correct? The debate is an important one because, if the first explanation holds true, improving upon the existing treatments might help, while the second implies that a completely different approach to treatment will be needed to root out the slowly dividing cancer ste
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Breast MRI helps predict chemotherapys effectiveness
2. Accelerated chemotherapy given before surgery benefits patients with muscle-invasive bladder cancer
3. Chemotherapys effect on overall survival seems to increase based on tumor size
4. Genetic predictor of breast cancer response to chemotherapy
5. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
6. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
7. Progress toward new chemotherapy agents
8. New genomic test spares patients chemotherapy with no adverse effect on survival
9. How chemotherapy becomes more effective
10. First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen
11. Aurora-A hinders tumor-suppressor to allow chemotherapy resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... The condition where veins are enlarged and ... often causing pain and discomfort. Those who spend a lot of time on their ... Vein Center is doing what it can to create awareness and provide a cure ...
(Date:8/1/2015)... ... 2015 , ... Tina Wilcoxson, owner of Freeport Maine’s Royal River Natural Foods, ... the National Retail Federation, the largest retail trade association in the world, for her ... owners to be named as such. According to the NRF’s website, Retail Champions are ...
(Date:8/1/2015)... ... August 01, 2015 , ... ... (“GPP”) portfolio company has acquired Premier Physical Therapy & Wellness (“Premier”) — with ... of state-of-the-art clinics. , “Our acquisition of Premier Physical Therapy & Wellness solidifies ...
(Date:8/1/2015)... ... August 01, 2015 , ... Lume Wellness creators Alex, Robert, and Sam ... on the Apple AppStore. , The app is designed to track various metrics ... a tool to view personal health and use this information for positive behavior modification. ...
(Date:8/1/2015)... ... 01, 2015 , ... “ reTXT ” was featured on NewsWatch as part ... on the market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch ... clarify, edit and delete any message including ones already sent. , While text messaging ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 2Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 3Health News:Local Retail Advocate Wins National Recognition 2Health News:Professional Physical Therapy Now Largest Outpatient Physical Therapy Provider in Northeast With Acquisition of Premier Physical Therapy & Wellness 2Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2
... that stimulates digestive nerves, U.K. study suggests , , MONDAY, ... recovery of intestinal function after all or part of ... researchers who reviewed data from five clinical trials involving ... pass contents after surgery (postoperative ileus) is normal among ...
... ... Patient, BEIJING, Aug. 18 ... and innovator of the high jump technique,dubbed the "Fosbury Flop," which revolutionized ... in March. After,undergoing surgery, radiation and chemotherapy treatment at the University,of New ...
... could be key, researchers say , , MONDAY, Aug. 18 (HealthDay ... up with an unruly head of hair from time to ... find out why it misbehaves -- and how to tame ... first of its kind, German researchers say they,ve gotten extreme-close-up ...
... PHILADELPHIA, Aug. 18 Independence Blue Cross (IBC),today ... the American Diabetes,Association,s (ADA,s) Step Out: Walk to ... October 4, 2008., The new family- and ... efforts to stem the growing diabetes epidemic by ...
... Aug. 18 For years, Labor Day has meant,picnics, ... millions,of working people, it also could rekindle memories of ... have to worry about health insurance. Times,are changing and ... health insurance coverage,especially in small businesses. The National Coalition ...
... whose families experience a high degree of interpersonal conflict ... compared with Asian Americans overall, according to a new ... is tripled even among those who have never had ... be reported during a 2 p.m. (EDT) poster session, ...
Cached Medicine News:Health News:Gum Chewing May Speed Colon Surgery Recovery 2Health News:Olympic Gold Medalist Inspires Cancer Patients Through Blog 2Health News:Science May Banish Bad Hair Days 2Health News:Independence Blue Cross Signs on as Presenting Sponsor of American Diabetes Association's Step Out: Walk to Fight Diabetes in Philadelphia 2Health News:Independence Blue Cross Signs on as Presenting Sponsor of American Diabetes Association's Step Out: Walk to Fight Diabetes in Philadelphia 3Health News:Independence Blue Cross Signs on as Presenting Sponsor of American Diabetes Association's Step Out: Walk to Fight Diabetes in Philadelphia 4Health News:Laboring Without Health Insurance? HSAs May Be an Affordable Option 2Health News:Suicide in Asian Americans 2
(Date:7/31/2015)... -- Quietly, sedately, Morocco,s pharmaceutical sector is ... industry is strong, with a well-developed base of local ... One place where the quality of Moroccan ... has quietly become the second largest African exporter of ... Indeed, Moroccan pharma companies have been making inroads as ...
(Date:7/31/2015)... SAN DIEGO , July 31, 2015 ... Eisai Co., Ltd. (Headquarters: Tokyo , ... Halozyme Therapeutics, Inc. (Headquarters: San Diego, California ... , "NASDAQ: HALO") have signed a clinical collaboration agreement ... , "eribulin") in combination with Halozyme,s investigational drug PEGPH20 ...
(Date:7/31/2015)... India , July 31, 2015 ... CRM solutions for video, data and cloud computing ... with a leading pharma giant for Internet of ... different IoT applications offered on subscription model. ... Pharma giant is striving for business innovations ...
Breaking Medicine Technology:PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... that a new market research report is available in ... Sales Forces , http://www.reportlinker.com/p0154035/Reportlinker-Adds-Reinventing-Pharmaceutical-Sales-Forces.html ... groups and leaner economic times have forced a new ... the previous decade is dead. Faced with the challenge ...
... Oct. 8 Ethicon Endo-Surgery today announced the company ... for the research and design process used in the ... company was recognized among thousands of entries for its ... collaboration with surgeons across the globe to identify specific ...
Cached Medicine Technology:Reportlinker Adds Reinventing Pharmaceutical Sales Forces 2Reportlinker Adds Reinventing Pharmaceutical Sales Forces 3Reportlinker Adds Reinventing Pharmaceutical Sales Forces 4Reportlinker Adds Reinventing Pharmaceutical Sales Forces 5Reportlinker Adds Reinventing Pharmaceutical Sales Forces 6Reportlinker Adds Reinventing Pharmaceutical Sales Forces 7Ethicon Endo-Surgery Wins Prestigious International Design Award for Innovative Development of HARMONIC FOCUS(TM) 2Ethicon Endo-Surgery Wins Prestigious International Design Award for Innovative Development of HARMONIC FOCUS(TM) 3
Amylase (EPS-G7, kinetics), Wavelength: 405 nm. Linear range; 5-1500 IU/L....
g-GT Liquid Reagent (Kinetic Method). Wavelength: 405 nm. Linear range: 0-200 U/mL. Prepare Working Reagent in the ratio of 5 parts R1 to 1 part of R2, (i.e., 50 mL R1 and 10 mL R2)....
Intended for the quantitative determination of calcium in serum. Endpoint Reaction. Reaction complete within one minute, color developed is stable for 30 minutes. Wavelength: 570 nm. Linearity: 16 mg...
... for the quantitative determination of ... or plasma. Two vials, dry ... must be purchased separately for ... reaction. Wavelength: 340 nm. Linearity: ...
Medicine Products: