Navigation Links
Why binge drinkers are slower to heal from their wounds
Date:4/8/2014

MAYWOOD, Ill. People who are injured while binge drinking are much slower to heal from wounds suffered in car accidents, shootings, fires, etc.

Now a new study is providing insights into why alcohol has such a negative effect on wound healing. Loyola University Chicago Stritch School of Medicine researchers report that binge alcohol exposure significantly reduced levels of key components of the immune system involved in healing.

The study by senior author Katherine A. Radek, PhD, and colleagues from Loyola's Alcohol Research Program and the Infectious Disease and Immunology Research Institute is published online ahead of print in the journal Alcoholism: Clinical and Experimental Research.

In the United States, alcohol dependence and/or abuse affects 20 percent to 40 percent of hospitalized patients. Alcohol increases the risk of infections in the hospital, including surgical site infections. Patients with surgical-site infections are hospitalized for twice as long, have a higher rate of re-admission and are twice as likely to die as patients who did not binge drink.

The study showed, for the first time, that binge alcohol exposure reduces the amount of white blood cells called macrophages that chew up bacteria and debris. This defect, in part, makes the wound more likely to be infected by bacteria, such as Staphylococcus aureus.

The study also found that binge alcohol exposure impaired the production of a protein that recruits macrophages to the wound site. (This protein is called macrophage inflammatory protein-1 alpha, or MIP-1α.) Binge alcohol also reduced levels of another key component of the immune system known as CRAMP (cathelicidin-related antimicrobial peptide). CRAMP is a type of small protein present in the outermost layer of the skin, the epidermis. These small proteins, called antimicrobial peptides, kill bacteria and recruit macrophages and other immune system cells to the wound site.

"Together these effects likely contribute to delayed wound closure and enhanced infection severity observed in intoxicated patients," researchers concluded.

The study involved an in vivo model and a typical pattern of binge drinking: three days of alcohol exposure, followed by four days without alcohol, followed by three more days of binge alcohol exposure. The binge alcohol exposures were equivalent to roughly twice the legal limit for driving.


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Cells appearing normal may actually be harbingers of lung cancer
2. Strong state alcohol policies protective against binge drinking
3. 14 Tips On How To Stop Binge Eating Disorder - Healthreviewcenter
4. PhenObestin 37.5 Suppresses Appetite as APA lists Binge-Eating as a Disorder
5. Frequent binge drinking is associated with insomnia symptoms in older adults
6. Binge eating curbed by deep brain stimulation in animal model, Penn study shows
7. Even in Young Adults, Binge Drinking May Harm Circulation
8. Lack of Sleep May Lead to Junk-Food Bingeing
9. Lower Drinking Age May Raise Chances of Bingeing Later
10. Lower drinking ages lead to more binge drinking
11. Sovereign Health of California Is Concerned About Recent CDC Findings Highlighting The Health Risk of Alcohol Abuse And Binge Drinking Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... Labs often ... it difficult for lab operators and management to assess these processes with a ... wasteful or unnecessary actions. , Created with the help of both internal ...
(Date:4/24/2017)... ... 2017 , ... “Reflections of God’s Work”: an enlightening collection of life lessons ... creation of published author, Jerri Broglin, a survivor of great loss who gained insight ... great eye-opener for those searching for answers, as we are finding the answers that ...
(Date:4/24/2017)... ... April 24, 2017 , ... Miami Periodontist ... 2017 Oral Reconstruction Foundation’s 2017 Symposium on Tissue Regeneration and Implant Dentistry held ... its annual Global Symposium at the Fontainebleau Hotel located in Miami Beach, FL. ...
(Date:4/24/2017)... ... April 24, 2017 , ... Anaconda BioMed, a ... systems for the treatment of Acute Ischemic Stroke (AIS), today announced it has ... the product advances towards regulatory and clinical phases. , "This is another important ...
(Date:4/23/2017)... ... April 23, 2017 , ... Altura ... the achievement of Cisco Select certification and SMB specialization. Altura is now ... , In earning the Select Certification, Altura fulfilled the training and exam ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical ... patients in Nashville , Tennesse have ... Esophageal Sphincter Stimulation for GERD (LESS GERD) trial. The ... provide long-term reflux control by restoring normal function to ... 65 million people in the United States ...
(Date:4/19/2017)... BOSTON , April 19, 2017  New research provides ... with advanced Parkinson,s, according to a study released today that ... 69th Annual Meeting in Boston , ... comes to the treatment of Parkinson,s disease, the oral drug ... of life and longevity. But as the disease progresses, the ...
(Date:4/18/2017)... Cogentix Medical, Inc. (NASDAQ: CGNT), a global ... and Gynecology markets with innovative and proprietary products, will ... 31, 2017 after the market close on Tuesday, May ... a conference call and webcast to discuss its financial ... at 4:30 p.m. Eastern Time (3:30 p.m. Central Time). ...
Breaking Medicine Technology: