Navigation Links
Why HIV patients develop dementia
Date:9/3/2014

respond by releasing harmful substances, such as reactive oxygen metabolites and inflammatory signalling molecules, i.e. cytokines. To test this hypothesis, the researchers developed a cell culture system in which they initially examined the effect of HIV-infected monocytes on microglial cells. The researchers simulated the individual steps of HIV infection and measured the volume of the cytokines released at each stage. Thus, they were able to demonstrate that releasing the viral RNA in the monocytes was a sufficient trigger for maximal microglial activation. Subsequent infection phases reverse transcription into DNA and the resulting formation of HIV proteins did not augment activation any further.

Released Substances Result in Neuronal Cell Death

In the second step, they analysed nerve cells from rat brains to determine if the substances released by the microglial cells could lead to cell death. Compared with the control group, the number of cell deaths was indeed twice as high. Studies of liquor cerebrospinalis received from HIV-infected patients have shown a positive correlation with marker of neuronal degeneration in patients who did not as yet present any neurocognitive disorders.

Detailed Understanding Necessary for Therapeutic Strategies

"Thanks to our research, we have gained a better understanding of the mechanisms of HIV-associated neurodegeneration," concludes Prof Dr Andrew Chan. "These results are likely to contribute to HAND biomarkers becoming established. In the long term, these data will be used to develop therapeutic strategies aiming at retarding HAND progression in HIV-infected patients." Starting points may include activation of microglial cells a method that is applied in other autoimmune diseases of the central nervous system, for example in multiple sclerosis.


'/>"/>
Contact: Simon Faissner
simon.faissner@rub.de
49-234-509-2411
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
3. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
4. Study finds doctors have exaggerated fears when starting patients on insulin
5. Diagnostic Scans Tied to Radiation Risk for Gastro Patients
6. Predictors identified for rehospitalization among post-acute stroke patients
7. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
8. Breast cancer patients suffer treatment-related side effects long after completing care
9. Heart failure patients with diabetes may benefit from higher glucose levels
10. Gastro Woes Often Strike Rheumatoid Arthritis Patients
11. Short Walks May Ease Fatigue in Pancreatic Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer ... coming Christmas. In the promotion, all buyers worldwide can ... have something special for the women who are looking ... our new collections of 2015 dresses have been unveiled ... greatly discounted prices. Visit our website now before they ...
(Date:12/20/2014)... December 20, 2014 The Twin Cities ... education event in the nation! Over 250 financial professionals ... minute information on the industry, get motivated to protect ... real people facing and overcoming the challenges of disability. ... across the nation came together to attend The 13th ...
(Date:12/19/2014)... Balfleet.com , a leading dress company of wedding ... All the old and new customers can get a ... well-known for its high quality trendy women’s dresses, like ... more. Its formal dresses are quality made and come ... an elegant look when paired with any accessory. ...
(Date:12/19/2014)... 2014 Sub Zero Ice Cream is partnering ... drive Sunday the 28th from 2pm-6pm at the Expo Center ... in Sarasota, FL. , Inquiries regarding time slots and signing ... in the donating process, Sub Zero Ice Cream & Yogurt ... ice cream. , About Sub Zero Ice Cream & Yogurt ...
(Date:12/19/2014)... Missouri (PRWEB) December 19, 2014 Silver ... new official world record -- for the first time ever, ... prestigious record book, Guinness World Records 2015, listing the park’s ... Wooden Roller Coaster. In additional awards announced this week, Silver ... See Christmas Lights in the US,” USA Today’s 10Best awards ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2
... 2011 -- Over 10 million people age 12 or older ... drugs in the prior year, according to a 2009 National ... most commonly detected non-alcohol drug in drivers, its role in ... between marijuana use by drivers and risk of a car ...
... -- New research suggests certain long-term psychotherapies may do ... stress disorder (PTSD) following a traumatic event. The ... PTSD didn,t seem to boost a person,s risk of ... when early clinical interventions cannot be provided," as might ...
... sinusitis is presented in a new thesis from Lund University. The ... the costs of the disease to society. Sinusitis is ... a chronic form. In Europe, over nine per cent of the ... thesis is Pernilla Sahlstrand Johnson, a PhD student and ear, nose ...
... , THURSDAY, Oct. 6 (HealthDay News) -- Technology that ... patients who were severely sickened by the H1N1 flu virus, ... their study had limitations, and they noted that debate continues ... At issue is a treatment called extracorporeal membrane oxygenation, which ...
... 6 (HealthDay News) -- People whose parents had a drinking ... they,re under stress, a new study says. Swedish researchers ... they had a family history of alcohol abuse. Both groups ... timed conditions in public) and then allowed to drink. ...
... HealthDay Reporter , THURSDAY, Oct. 6 (HealthDay ... children treated in emergency rooms for traumatic brain injuries, ... report from the U.S. Centers for Disease Control and ... saw 248,418 children with traumatic brain injuries compared to ...
Cached Medicine News:Health News:Marijuana use may double the risk of accidents for drivers 2Health News:Researchers Assess What Works Best to Prevent PTSD 2Health News:New method to diagnose sinusitis could reduce use of antibiotics 2Health News:Oxygenating Blood of Hospitalized H1N1 Flu Patients Saved Lives: Study 2Health News:More Kids Treated for Concussions in ERs: CDC 2Health News:More Kids Treated for Concussions in ERs: CDC 3
(Date:12/19/2014)... Dec. 19, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Healthcare Conference on Wednesday, Jan. 14, 2015, in ... to begin at 10:30 a.m. Pacific time on Wednesday, ... interested parties through a live audiocast accessible via the ...
(Date:12/19/2014)...  Monarch America Inc. (OTCQB: CANK) ("Monarch America" or ... provide this review of the Company,s recent achievements and ... "Over this past year, we achieved many of our ... to say that Monarch America is in a stronger ... been," stated Eric Hagen , CEO of Monarch ...
(Date:12/19/2014)... YORK , Dec. 18, 2014 Somewhere ... addressing hearing health was forgotten. But Audicus , ... to hear better this new year. Hearing ... facing the aging population, though it is often unaddressed. ... in four has a hearing aid, mainly due to ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Audicus Will Help People Resolve to Hear Better in 2015 2
... 8 Varian Medical Systems (NYSE: VAR ) ... of fiscal year 2010 following the close of regular trading ... followed by a teleconference available to all interested parties at ... the conference call webcast will be available on the company ...
... growing number of healthcare providers are choosing the ... control over non-file, off-contract spending, focusing on high-cost ... healthcare decision-makers receive sound content, accurate contract price ... rather than after the fact. With greater contract ...
Cached Medicine Technology:Varian Medical Systems Schedules Fourth Quarter FY2010 News Release and Conference Call 2Healthcare Providers Gain Control of Demand Channels With GHX Procurement Suite; 12 Percent Supply Spend Savings Achievable 2Healthcare Providers Gain Control of Demand Channels With GHX Procurement Suite; 12 Percent Supply Spend Savings Achievable 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: