Navigation Links
Why BPA leached from 'safe' plastics may damage health of female offspring
Date:2/25/2010

Here's more evidence that "safe" plastics are not as safe as once presumed: New research published online in The FASEB Journal (http://www.fasebj.org) suggests that exposure to Bisphenol A (BPA) during pregnancy leads to epigenetic changes that may cause permanent reproduction problems for female offspring. BPA, a common component of plastics used to contain food, is a type of estrogen that is ubiquitous in the environment.

"Exposure to BPA may be harmful during pregnancy; this exposure may permanently affect the fetus," said Hugh S. Taylor, Ph.D., co-author of the study from Yale University School of Medicine in New Haven, Connecticut. "We need to better identify the effects of environmental contaminants on not just crude measures such as birth defects, but also their effect in causing more subtle developmental errors."

Taylor and colleagues made this discovery by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses. Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression. These epigenetic changes caused the mice to over-respond to estrogen throughout adulthood, long after the BPA exposure. This suggests that early exposure to BPA genetically "programmed" the uterus to be hyper-responsive to estrogen. Extreme estrogen sensitivity can lead to fertility problems, advanced puberty, altered mammary development and reproductive function, as well as a variety of hormone-related cancers. BPA has been widely used in plastics and other materials. Examples include use in water bottles, baby bottles, epoxy resins used to coat food cans, and dental sealants.

"The BPA baby bottle scare may be only the tip of the iceberg." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Remember how diethylstilbestrol (DES) caused birth defects and cancers in young women whose mothers were given such hormones during pregnancy. We'd better watch out for BPA, which seems to carry similar epigenetic risks across the generations. "


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Toyota Recalls Raise Awareness of Vehicle Safety Issues, Risks of Accidents from Driving Defective Automobiles
2. The Coalition for Vaccine Safety Calls for Congressional Hearings on Federal Agencies Failure to Provide Adequate Safety Research
3. Bitrex Bitter Safety Additive Exhibiting at the Safe Kids Fair 2010; Making a Bitter Face to Learn about Poisoning Prevention
4. Tests to Measure Safety of Anti-Clotting Drugs of Limited Value
5. Clarity Group, Inc. Announces Launch of Portal 2.0, the Next Generation of the Healthcare SafetyZone Portal
6. As Temperature Plummets, Its Still Safe to Exercise
7. RetireSafe Survey Says Seniors Are Struggling With Increased Costs Without an Increased Social Security Cost of Living Adjustment
8. JPMA Supports CPSC Chairman Tenenbaum's Continued Safety Efforts
9. Registered Nurses from Public Health - Seattle & King County Hold Informational Picket to Highlight Public Safety Concerns
10. Sacred Heart Medical Center Cited for Violation of Safety Standards in H1N1 Prevention
11. New Safety Bath and Sill Mats Help Prevent Slip and Fall in Bathrooms - from Martinson-Nicholls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... LELO has discovered many ... LELO fans reach out via email, social media and on the Volonté blog seeking ... the way I masturbate ‘normal’ or ‘correct’?” , While some methods are more common ...
(Date:5/5/2016)... IN (PRWEB) , ... May 05, 2016 , ... ... benefits advisory organization, announces McLaughlin & Smoak Benefits as the latest addition to ... Smoak Benefits has a dedicated team of compliance, wellness, human resources, and health ...
(Date:5/5/2016)... ... ... Derrin Doty Group has unveiled the latest charity campaign in their ongoing ... Seattle. The insurance provider’s caring team has been so moved by the sudden death ... from the flu, that they have decided to extend their original campaign. Compassionate community ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every year 220 Mississippi kids ... of these children. The wishes provide hope and motivation through positive experiences ... Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization will grant 50% of ...
(Date:5/5/2016)... MA (PRWEB) , ... May 05, 2016 , ... ... among workers’ compensation laws in all U.S. states and certain Canadian provinces is ... and the Workers Compensation Research Institute (WCRI). , The report, Workers’ ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Grand Cayman , May 5, 2016 Progra ... successful trial of Oxitec , s mosquito ... Aedes aegypti by 96 % ... (MRCU) announced a new plan to fight wild Aedes aegypti, the ... these diseases on the island of Grand Cayman .  MRCU, ...
(Date:5/5/2016)... , May 5, 2016  Diagnostic imaging ... decade due to concerns that these tests cause health ... approach to imaging, as well as the adoption ... era of medical peripherals that help health care providers cut ... Ampronix  advanced medical imaging is a renowned authorized reseller ...
(Date:5/5/2016)... May 5, 2016 Research and ... PET Imaging in the USA"  report to their offering.  ... information on the current Positron Emission Tomography (PET) scanner ... market. Along with the current known number ... USA , the report also contains a detailed ...
Breaking Medicine Technology: