Navigation Links
Why Antidepressants Don't Work for Everyone
Date:1/13/2010

Level of 'autoreceptors' is the key, say researchers working with mice

WEDNESDAY, Jan. 13 (HealthDay News) -- New research is giving scientists a greater understanding of how a brain becomes susceptible to depression and anxiety on a molecular level and why some people are resistant to antidepressants.

Scientists think two things -- biological factors and stressful life events -- cause the mental disorders. Antidepressants (such as Prozac) are available to treat them, often by increasing serotonin levels, but they don't always work.

"Unfortunately, more than half of all depressed patients fail to respond to their first drug treatment," senior study author Rene Hen, of Columbia University, said in a news release. "The reasons for this treatment resistance remain enigmatic. Elucidating the exact nature of both the factors predisposing to depression and the mechanisms underlying treatment resistance remains an important and unmet need."

In the study, researchers used mice to investigate the way the brain deals with serotonin. The brain's mechanism for handling serotonin appears to be related to levels of so-called "autoreceptors," the study authors found. Mice with higher levels didn't respond to treatment with antidepressants, but they did better when the levels went down, the study showed.

The research could lead to treatments to make people more responsive to antidepressants before they take them, Hen said.

The findings are published in the Jan. 14 issue of the journal Neuron.

More information

The U.S. National Library of Medicine has more on antidepressants.



-- Randy Dotinga



SOURCE: Cell Press, news release, Jan. 13, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Antidepressants May Raise Womens Stroke Risk
2. Most Antidepressants Miss Key Target of Clinical Depression
3. Antidepressants May Change Your Personality
4. Why antidepressants dont work for so many
5. Antidepressants May Be Linked to Birth Problems
6. Antidepressants Linked to Heart Defects in Newborns
7. Antidepressants: Benefit of SNRI is proven
8. Suicide Risk With Antidepressants Falls With Age
9. Almost 1 quarter of Spanish women take antidepressants
10. Antidepressants aid electroconvulsive therapy in treating severe depression
11. Preliminary report on antidepressants published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... On the ... effectively doubled the size of its annual health tech innovation program. Now featuring ... health startups to compete for cash and prizes to advance their technologies toward ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... IVF New ... host a New Hampshire fertility "ManchVegas Happy Hour" in Manchester for women who wish ... 15, 2015 at XO on Elm restaurant and lounge, 827 Elm Street, Manchester, NH ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... “Partner of the Year” awards at this year’s Microsoft Worldwide Partner Conference that ... “Partner of the Year” Award Winner for Data Platform services, the 2015 HP ...
(Date:9/4/2015)... ... ... consumers are looking for a quick and convenient way to produce a hot remedy for ... provide a quick and simple way to brew a hot cup of cold remedy when ... result, they enhance comfort and health. The invention features a novel design that is lightweight, ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... its first neighborhood created specifically for adults with intellectual, developmental and acquired disabilities. ... area and feature 30 cottage or “pocket” homes. In this community, adults will ...
Breaking Medicine News(10 mins):Health News:Insight Product Development Startup Competition on Track to Double Program Impact 2Health News:Insight Product Development Startup Competition on Track to Double Program Impact 3Health News:IVF New England to Host ManchVegas New Hampshire Fertility Happy Hour on October 15, 2015 in Manchester for Women Who Wish to Learn More About Fertility and Egg Freezing 2Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 2Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 3Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 4Health News:Redesigned Packaging for Powdered Medicinal Mix Invented by InventHelp® Client (CBA-2637) 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4
... Sponsor a Recipient of American Academy of Nursing Award for ... Innovation in ... of the potential,impact of state mandated nurse-to-patient staffing ratios in ... areas,of patient care. The findings were published in the March ...
... - Completed LogistiCare acquisition ... - Vanderbilt study released showing 81% success ... $23 million from LogistiCare and $6 million from social services ... segment, - Fourth quarter diluted earnings ...
... WASHINGTON, March 12 With the cost ... the Deloitte Center for Health,Solutions finds that ... advances can dramatically improve care and drastically ... Technology Enabled Care at Home,",( http://www.deloitte.com/us/connectedcareathome ) ...
... WASHINGTON, March 12 The following was,issued today ... Quality Forum (NQF) Implementation Conference on Care,Coordination and ... available,at http://www.qualityforum.org ., March 26: Spring ... between NQF membership and leaders of the National ...
... perplexed by the fact that some patients given ... treat persons diagnosed with head and neck cancer, ... reaction to the drug. Sometimes the reaction includes ... in blood pressure, fainting, difficulty breathing, and wheezing. ...
... use ibuprofen for arthritis pain or other conditions while ... stroke undermine aspirins ability to act as an anti-platelet ... , In a cohort of patients seen by physicians ... patients were identified as taking both aspirin and ibuprofen ...
Cached Medicine News:Health News:California Study Offers New Perspective on Relationship Between Staffing Ratios and Patient Safety 2Health News:California Study Offers New Perspective on Relationship Between Staffing Ratios and Patient Safety 3Health News:California Study Offers New Perspective on Relationship Between Staffing Ratios and Patient Safety 4Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 2Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 3Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 4Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 5Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 6Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 7Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 8Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 9Health News:Providence Service Corporation Announces Fourth Quarter 2007 Revenue and Earnings Above Forecast; Issues First Quarter 2008 Guidance 10Health News:Deloitte's 'Connected Care' Model Promotes Technologically Enabled In-Home Health Care, Projects Future Health Care Savings in the Billions 2Health News:Deloitte's 'Connected Care' Model Promotes Technologically Enabled In-Home Health Care, Projects Future Health Care Savings in the Billions 3Health News:National Quality Forum Spring Conference; Leaders in Healthcare Quality to Focus on National Priorities and Care Coordination 2Health News:Researchers find cause of severe allergic reaction to cancer drug 2Health News:Researchers find cause of severe allergic reaction to cancer drug 3Health News:Ibuprofen destroys aspirin's positive effect on stroke risk 2Health News:Ibuprofen destroys aspirin's positive effect on stroke risk 3
(Date:9/4/2015)... , Sept. 4, 2015  Essilor is pleased to ... greatest defense against the eyestrain that comes with the ... to serve as an everyday pair of glasses to ... who are on smart phones, tablets and computers for ... those who require a prescription but also those who ...
(Date:9/4/2015)... PUNE, India , September 4, 2015 ... "Apheresis Market by Application (Plasmapheresis, Plateletpheresis, Erythrocytapheresis, Leukapheresis, and ... by Technology and by Product - Global Forecast to ... expected to reach USD 2.5 Billion by 2020, growing ... from 2015 to 2020. Browse 139 ...
(Date:9/4/2015)... Sept. 4, 2015  Allergan plc (NYSE: AGN ) ... Saunders , CEO and President of Allergan, will provide an ... Stanley Global Healthcare Conference 2015 in New York, ... The presentation will take place on Thursday, ... Grand Hyatt New York, 109 East 42nd Street, ...
Breaking Medicine Technology:Essilor Launches New Eyezen Glasses Specifically Designed For A Digital Focused Audience 2Apheresis Market Worth 2.5 Billion USD by 2020 2Apheresis Market Worth 2.5 Billion USD by 2020 3Apheresis Market Worth 2.5 Billion USD by 2020 4Apheresis Market Worth 2.5 Billion USD by 2020 5Allergan to Present at Morgan Stanley Global Healthcare Conference 2015 2Allergan to Present at Morgan Stanley Global Healthcare Conference 2015 3
... College of Emergency Physicians, a national sponsor of the ... safe disposal of expired, unused and unwanted medications in ... accidental overdose.  A recent study reports that prescription drugs ... 2008, more than half of the total 36,450 overdose ...
... The U.S. Food and Drug Administration today approved the ... heart valve damaged by senile aortic valve stenosis without ... Senile aortic valve stenosis is a progressive, age-related disease ... cause the valve to narrow. As the heart works ...
Cached Medicine Technology:Emergency Physicians Tell the Public,''Get Rid of Your Stash'' of Unwanted Meds on November 12th 2FDA Approves First Artificial Aortic Heart Valve Placed Without Open-Heart Surgery 2FDA Approves First Artificial Aortic Heart Valve Placed Without Open-Heart Surgery 3
100L...
... A fixed pipette is ideal ... single volume. Fixed volume FInnpipettes ... advantages as other Finnpipette Digital ... Super blow-out (1-40ul), Soft-touch tip ...
This fixed-volume digital micropipet is used to accurately measure and transfer 20 microliters of solution....
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: