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Whole-parasite malaria vaccine shows promise in University of Maryland School of Medicine clinical trial
Date:9/9/2011

s have shown that the bites of infected, irradiated mosquitoes have the ability to immunize humans against malaria. In fact, previous trials pioneered at the University of Maryland School of Medicine and the U.S. Navy almost 40 years ago showed that 90 percent of humans bitten by at least 1,000 irradiated malaria-carrying mosquitoes did not contract malaria from the bites of ordinary malaria-infected mosquitoes. However, the bite of a mosquito essentially using a mosquito as a syringe and needle is not a practical method of administering a vaccine to large groups of people. Sanaria's large-scale production and cryopreservation process creates the potential for the vaccine to be administered globally.

"The University of Maryland School of Medicine and its Center for Vaccine Development have a world-leading malaria research program with a prominent global presence, including in remote areas of Africa where malaria rates are at their worst," says E. Albert Reece, M.D., Ph.D., M.B.A., vice president for medical affairs for the University of Maryland and John Z. and Akiko K. Bowers Distinguished Professor and dean, University of Maryland School of Medicine. "This research is the culmination of decades of study in this field, and brings hope to the millions of people worldwide who face daily threat of malaria."

The study included 98 adult volunteers, 18 of whom served as control volunteers. As a Phase I trial, the study's focus was to establish that the vaccine was safe and well tolerated. The results have guided the design of the next study, a Phase II clinical trial in which scientists will administer the vaccine intravenously to human volunteers and measure immunity to determine the effectiveness of Sanaria's vaccine. Scientists have traditionally regarded intravenous delivery as an impractical strategy for large-scale global immunization, but Dr. Lyke said the researchers will evaluate its potential in future studies. Other possibilities for admin
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Contact: Karen Robinson
karobinson@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

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