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"Typically you would expect weight loss to be associated with a decrease in C-reactive protein, but the refined grain group showed no decrease in this marker of inflammation even though they lost weight," said Kris-Etherton.

The Penn State researcher suggests that the finding is because the consumption of refined grains has been linked to increased levels of the protein. So even though people in the refined grain group lost weight, the fact that they ate so many refined grains probably negated the beneficial effect of weight loss on C-reactive protein levels.

While it is not fully clear how exactly the protein is decreased in the whole grain group, Richard Legro, M.D., professor of obstetrics and gynecology at Penn State Hershey Medical Center and a co-investigator, says the scale of reduction is similar to that seen with the use of statin drugs, highlighting the potential of diet to prevent serious medical complications.

Participants in the whole grain group also showed an increased intake of fiber and magnesium, both of which may prevent or delay the potential onset of diabetes.

Researchers say the study is timely as it addresses the wide choice of whole grains in the market.

"There are a lot of foods around that claim they contain whole grain but are not really major sources of whole grain," said Kris-Etherton. She recommends whole grain foods where at least 51 percent of the grain comes from whole grain. These include oatmeal, whole grain cereal, brown rice, whole-wheat pasta and snacks such as granola bars, popcorn and whole-wheat crackers.

"This is the first clinical study to prove that a diet rich in whole grains can lead to weight loss and reduce the risk of several ch
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