Navigation Links
Whole-genome scan helps select best treatment for childhood cancer
Date:9/14/2012

A whole-genome scan to identify large-scale chromosomal damage can help doctors choose the best treatment option for children with neuroblastoma, one of the most common types of childhood cancer, finds an international collaboration jointly led by The Institute of Cancer Research, London.

The researchers called for all children diagnosed with neuroblastoma worldwide to have a whole-genome scan as a standard part of their treatment.

Neuroblastoma, a cancer of the developing nervous system, is sometimes very treatable but other forms are highly aggressive, making the disease overall one of the leading causes of death from childhood cancer. As intense treatments can carry life-long side-effects, identifying the form is crucial in giving an accurate prognosis and deciding the most appropriate care.

Scientists examined the medical records of 8,800 neuroblastoma patients from around the world and found that several large-scale genetic faults were strongly linked to survival rates, and that a whole-genome scan would therefore be more effective at predicting prognosis than tests for individual genetic factors. The study is published in the British Journal of Cancer today.

Senior author Professor Andy Pearson, Cancer Research UK professor of paediatric oncology at The Institute of Cancer Research and a paediatric consultant at The Royal Marsden NHS Foundation Trust, said: "Our study has found that every single patient diagnosed with neuroblastoma should have a whole genome assessment. The technology required to carry out these scans has become much more widely available and cheaper over recent years, and we believe most diagnostic labs in developed countries worldwide should have this capacity. These gene tests would help doctors provide a more accurate prognosis and decide the best treatment for their patients, which could potentially save more lives and spare other children the risk of serious side-effects."

The study builds on earlier work by the same international team, called the International Neuroblastoma Risk Group, who proposed classifying tumours based on 13 characteristics including the status of three genetic alterations (ploidy, MYCN and the segmental gene alteration 11q). Since the system was introduced four years ago, scientists' understanding of the genetic causes of aggressive neuroblastoma has improved and evidence has emerged of a number of other mutations that may be relevant to the disease.

The new study links two further segmental gene alterations - mutations that involve the duplication or deletion of large sections of DNA to patient survival, specifically 1p status and 17q status. It further concluded that scanning the whole genome provided the most prognostic information, as it took all these factors into account along with less frequent but important genetic changes that also had an impact on survival. The team is now planning to update the official classification system to incorporate the new information, which should improve the personalised approach to therapy for neuroblastoma.


'/>"/>
Contact: ICR Science Communication Manager Jane Bunce
jane.bunce@icr.ac.uk
44-207-153-5106
Institute of Cancer Research
Source:Eurekalert

Related medicine news :

1. New software helps reveal patterns in space and time
2. LifeSkills training helps teens manage anger, lower blood pressure
3. Theres an app for that: Apple iPod Touch helps adults with autism function in the workplace
4. New technique helps determine degree of muscle wasting in critically ill patients
5. Intervention helps children with sickle cell disease complete MRI tests without sedation
6. Study helps pancreatic cancer patients make hard choices
7. Radiation after lumpectomy helps prevent need for mastectomy in early stage breast cancer
8. Mechanical Device Helps Kids Waiting for Heart Transplant
9. More Evidence That Exercise Helps Fight Diabetes
10. Blue light helps tired workers and motorists regulate their internal clocks
11. IL-10 from donor skin cells helps the body incorporate skin grafts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... patient advocates stress that the patient context (age, illness and life choices) should ... to mitigate their occurrence. In addition, all too often, studies regarding ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... chain management (SCM) and spend management, today announced that Keppel Corporation has selected ... simplify expense tracking. , “We are excited to announce the partnership between ...
(Date:2/21/2017)... , ... February 22, 2017 , ... Author Michèle Wolff ... valuable for every household and family to know all about it for optimal health. ... with the release of “ Detox, Digestive and Wellness Solutions ” (published by Balboa ...
(Date:2/21/2017)... IL (PRWEB) , ... February 21, 2017 , ... ... connectivity solutions, has introduced five new hospital-grade power extension cords that meet the ... Services (CMS) of the 2012 edition of the National Fire Protection Association (NFPA) ...
(Date:2/21/2017)... ... 21, 2017 , ... Doctors on Liens has announced the addition of ... , to its growing network of doctors in Central and Northern California. Dr. Mendonca ... such as whiplash, back pain, neck pain, hip and knee pain, and headaches. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Research and Markets has ... by Drug Molecule (Biologic, Small Molecule Drugs), By Route of ... Blockers) Outlook 2022" report to their offering. ... The global psoriasis ... 2016-2022 This report provides a detailed analysis of ...
(Date:2/22/2017)... -- Based on its recent analysis of the sleep ... Inc. with the 2017 European New Product Innovation ... intelligently addresses the root causes of sleep apnea ... proven continuous transmucosal electrical stimulation therapy. Because of ... the most accessible anti-snoring products available in the ...
(Date:2/22/2017)... HAYWARD, Calif. , Feb. 22, 2017  Applied Silver, ... Sue Barnes to the company,s advisory board. Ms. Barnes ... total, joining business, advertising, engineering, legal, and healthcare experts ... , John Goodrich , J. Tress Ritter , ... RN, BSN, CIC, FAPIC brings more than three decades of ...
Breaking Medicine Technology: