Navigation Links
Whole fresh blood for transfusions may have a longer shelf life than now assumed

In a finding that may potentially improve survival from war injuries and disasters, laboratory researchers report that refrigerated whole blood may have a shelf life well beyond the current standard of 24 to 48 hours.

"We have found that whole blood retains its clotting properties at least 11 days under standard refrigeration," said the study leader, David Jobes, M.D., a cardiothoracic anesthesiologist in the Cardiac Center at The Children's Hospital of Philadelphia. "If this lab discovery can be confirmed in human subjects, it may lead to a change in clinical practice, and possibly to improved survival for massively transfused patients."

The study appears in the January 2011 issue of the journal Transfusion.

The majority of patients receiving blood transfusions only require specific components of whole blood, such as red blood cells, plasma and platelets. However, whole blood may be preferable in specific situations such as infant heart surgery and combat casualties.

The definition of freshness of whole blood with respect to its clotting properties has not been systematically studied. The current practice at The Children's Hospital of Philadelphia assumes a fresh whole blood shelf life of 48 hours when refrigerated. After that point, the red blood cells may be recovered from the whole blood, but the other components, such as plasma and platelets must be discarded. "In any case, postponed surgeries currently waste resources," said Jobes.

Based on reports from military clinicians and on the authors' own observations in pediatric cardiac surgery, Jobes and colleagues did a laboratory study to measure the duration of blood coagulation properties in refrigerated whole blood.

The researchers used 21 units of whole blood from healthy volunteer donors, performing the study in the hematology and coagulation laboratory led by Long Zheng, M.D., Ph.D., in the clinical laboratory at The Children's Hospital of Philadelphia. They found that thromboelastography (TEG) and platelet aggregation levels, which measure the efficiency of blood coagulation, remain normal at least 11 days under standard refrigerated conditions.

If these results hold up under follow-up studies in human subjects, a change in current practice could increase the availability and usefulness of whole blood, especially in military or disaster relief situations, and in remote locations. "Trauma patients could potentially benefit, as well as others needing a large volume of blood replacement, such as patients undergoing liver transplant or children who need craniofacial reconstruction," said Jobes.

Furthermore, Jobes added, more efficient use of donated whole blood, besides reducing wastage, could lower the number of donors needed, and thus increase safety by reducing the risks of inadvertently transmitting blood borne viruses.

In all, said Jobes, "Our results strongly suggest that clinical trials should proceed to test the value of whole blood beyond a 48-hour period."


Contact: Joey McCool Ryan
Children's Hospital of Philadelphia

Related medicine news :

1. US21, Inc. is Granted a Wholesale Distributor Permit from the Commonwealth of Virginia Board of Pharmacy
2. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
3. Thomas E. Mower Meets With Dalai Lama; Receives Prestigious Champion Award from Whole Child International
4. Chlorella: A Green Whole Food That Can Help Improve the American Diet
5. VIDEO from Medialink and Juice Products Association: Teens Who Drink Juice Have Healthier Diets, Eat More Whole Fruit
6. Whole Grains Take a Bite Out of Type 2 Diabetes Risk
7. MMAR Medical Expands Wholesale Offering with Cybertech Distribution Deal
8. Organic Wholesale Club Brings Wholesale Club Concept to Large Organic and Natural E-commerce Site
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Whole body MRI is highly accurate in the early detection of breast cancer metastases
11. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: