Navigation Links
Which segments of the gastrointestinal tract does Salmonella enteritidis penetrate?
Date:1/16/2008

Incidence of Salmonella enteritidis infection is common in hospitals for children, the elderly, and immuno-suppressed individuals. A paper in the December 28, 2007 of the World Journal of Gastroenterology (volume 5, issue 48) is notable because of its potential significance for Salmonella enteritidis therapy in the future.

Salmonella enteritidis can be transmitted to humans through the food production chain. In China, the consumption of poultry products is very high. However, Salmonella enteritidis in the poultry industry has risen dramatically in recent years. As a result of its increased prevalence and its complex life cycle, identifying the regular distribution pattern of Salmonella enteritidis in the gastrointestinal tract will help us to understand its mechanism of action. To discover the port of entry, Dr. Cheng et al (Sichuan Agricultural University, China) used a serovar specific real time PCR for the detection and quantification of Salmonella enteritidis in the gastrointestinal tract of mice.

Based on their results, the jejunum and ileum were positive at 8 h post inoculation and the DNA copies number of Salmonella enteritidis being 10 - 10,000 times more than those in other regions over a 9 d period. One conclusion reported by the investigators is that the jejunum and ileum are the primary sites for Salmonella enteritidis penetration after oral challenge, and these sites are responsible for the organism reaching the heart, liver and spleen.

The reservoir for Salmonella enteritidis is mainly poultry, often adopting asymptomatic infection, and Salmonella enteritidis colonization in the gastrointestinal tract can persist for as long as 18 wk PI in hens. Dr. Cheng et al also found Salmonella enteritidis can present up to 9 d post inoculation in the jejunum, ileum and cecum, without causing apparent symptoms. Does this mean Salmonella enteritidis sets itself up as a commensal over a long time in humans too? This finding is of great significance for future studies; and this paper may increase the evidence that Salmonella enteritidis is a kind of opportunistic pathogen in humans.

Finally, rapid identification of Salmonella enteritidis based on a specific real-time PCR amplifying species specific DNA sequence is a wonderful tool for clinical diagnosis. We believe this study will aid understanding of the mechanisms of action of Salmonella enteritidis infection in vivo, and encourage new studies on how to produce medicines to prevent and treat Salmonella enteritidis infection.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. The science behind the food we eat and the earth on which it grows
2. Which intervention would do the most to improve the health of the extreme poor?
3. Marlo Thomas and St. Jude Childrens Research Hospital(R) Announce Hitting The 50-Partner Milestone as They Kick Off the Fourth Annual Thanks and Giving(R) Campaign Which Asks America to Support St. Jude While Shopping This Holiday Season
4. The Polls are Open! America Votes to Decide Which Hospital is the Most Deserving of Siemens Newest MRI Technology
5. HearAtLast Spokesperson Walter Gretzky and President Robert Oswald to be Featured on Three TV Segments in Conjunction with Ottawa Store Opening
6. Anti-depressant drugs can double risk of gastrointestinal bleeding
7. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
8. Supratek Pharma Inc. announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for SP1049C for the treatment of metastatic adenocarcinoma of the upper gastrointestinal tract
9. The 2008 Gastrointestinal Cancers Symposium
10. Different method of evaluating the urinary tract system reduces radiation dose
11. Providence St. Joseph Medical Center, Caregivers Reach Agreement on a Union Contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Splashtop Inc., ... its strategic partnership with e-Jan Networks Co., the leading provider of secure mobile ... customers of e-Jan Networks’s leading CACHATTO remote access solution. Splashtop for ...
(Date:5/31/2016)... ... May 31, 2016 , ... Twenty years ago it was revolutionary: enabling the ... silence the voices they hear. But this approach has proven transformative, both for people ... steadily gained credibility and now is used around the world, but it still lags ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... Corporation, he knew it was something that contractors should have at their disposal ... it gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a ...
(Date:5/31/2016)... ... May 31, 2016 , ... CallTrackingMetrics's software gives ... monitor the performance of sales and support staff, and to efficiently route calls ... allows customers to record, transcribe, route, document, and report on everything going on ...
(Date:5/31/2016)... Newport Beach, Calif. (PRWEB) , ... May 31, 2016 , ... ... trust among colleagues, clients, and the industry as a whole. On June 2, Northbound ... Coast Symposium on Addictive Disorders (WCSAD) and presenting the opening plenary on “Leadership: The ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... VALLEY COTTAGE, New York , May 31, 2016 ... traction as an essential ingredient in food, cosmetics and ... 2016 end, representing revenues worth US$ 1.6 Bn. ... vera gels, cosmetics products, juices, and yogurts will continue ... health and wellness trend will also boost positive sentiment ...
(Date:5/31/2016)... May 31, 2016 , Isansys  Lifecare, ... its Patient Status Engine wireless patient monitoring platform, as it ... Germany , Scotland and ... 2 nd generation system, launched earlier this year, is now ... , , This new technology significantly enhances ...
(Date:5/30/2016)... , May 30, 2016 ... report "Healthcare Biometrics Market by Technology (Single-factor ... Multifactor, Multimodal), Application (Workforce Management), End User ... 2021", published by MarketsandMarkets, the market is ... 2021 from USD 1,182.6 Million by 2016, ...
Breaking Medicine Technology: