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Where You Put on Pounds May Influence Clot Risk
Date:10/26/2009

than 12 years and found an association between VTE risk and metabolic syndrome, a constellation of risk factors including obesity, high blood pressure, insulin resistance and high blood cholesterol. A heightened risk of VTE was attributed to obesity.

"The message here is that obesity is a risk factor for venous thrombosis," Steffen said. "The effect of obesity in women might be the same as in men, but just is not measured in waist circumference."

It's possible that obesity increases the likelihood of developing blood clots, and it also might have a negative effect on the endothelium, the delicate lining of blood vessels, Steffen said.

"There is information that obesity contributes to inflammation, and it is associated with the metabolic syndrome, which predisposes to stroke," said Dr. Amytis Towfighi, an assistant professor of clinical neurology at the University of Southern California. "There may be similar effects in thrombotic disease, as well as mechanisms that are not well understood at this point."

More information

Learn more about venous thrombosis from the U.S. National Heart, Lung, and Blood Institute.



SOURCES: Lyn Steffen, Ph.D, associate professor, epidemiology, University of Minnesota School of Public Health, Minneapolis; Amytis Towfighi, M.D., assistant professor, clinical neurology, University of Southern California, Los Angeles; Oct. 26, 2009, Circulation, online


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