Navigation Links
When your left hand mimics what your right hand does: It's in the genes
Date:2/17/2012

Further work carried out on mice suggests that this gene plays a part in motor network cross-over. Cross-over is a key factor in the transmission of brain signals, because it allows the right side of the brain to control the left side of the body and vice versa. This research has been published in The American Journal of Human Genetics.

Congenital mirror movement is a rare disease transmitted from one generation to another by dominant inheritance. The affected persons lose the ability to carry out different movements with separate hands: when one hand moves in a certain way, the other hand is "forced" to copy the same movement, even if the person does not wish to do so. So people suffering from this disease are totally incapable of bimanual motor activities, such as piano playing for example. This phenomenon has been observed in children, but generally cleared up spontaneously before the age of 10, no doubt due to maturing of the motoneuron networks. However, in people who are affected by the disorder, the illness starts in early childhood and remains unchanged throughout life.

In 2010, research scientists from Quebec analyzed the genome from the members of a large Canadian family and discovered a gene responsible for the disease. Mutations had been detected in the DCC (Deleted in Colorectal Carcinoma) gene. Following this discovery, the team of researchers and doctors coordinated by Emmanuel Flamand-Roze began to search for mutations in this gene in several members of a French family who were also suffering from congenital mirror movements disease, but without success. "The DCC gene was intact", explained Emmanuel Flamand-Roze. "We thought we were nearly there and instead we had to start searching for mutation in a different gene", he adds.

Using an approach that combines conventional genetic analysis and "whole exome" analysis (a new-generation genetic analysis technique that involves entirely sequencing the important part of the genome), scientists demonstrated that the RAD51 gene was responsible for congenital mirror movement disease in a large French family and went on to corroborate this result using the same techniques on a German family suffering from the same disorder.

"The RAD51 gene was already known to the scientific community as a potential catalyst for certain types of cancer and in problems of resistance to chemotherapy", explains Emmanuel Flamand-Roze. "So we wondered whether it had yet another function that could explain the motor symptoms of CMM disease".

In humans, the motor system is a cross-control system, which means that the left side of the brain controls the motor functions of the right side of the body and vice versa, with the cross-over taking place at the brainstem. While studying the expression of the RAD51 protein during development of the motor system in mice, the research scientists discovered that this gene could be implanted into the cross-over of the motor network that links the brain to the spinal fluid at the brainstem.

This discovery opens up a whole new field of investigation into the development of the motor system and to achieving better understanding of the cerebral mechanisms that control bimanual motricity. It could also shed light on other motricity disorders related to fine movement organization, such as dystonia or certain genetic neurodevelopmental diseases.


'/>"/>
Contact: Inserm Presse
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related medicine news :

1. Psychopaths Lack of Empathy Mimics Brain Injury: Research
2. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
3. Queens study shows the rights of people with disabilities are not being promoted
4. Dentist Gives Advice to Keep Holiday Smiles Bright
5. Good intentions may hamper progress in pursuit of global reproductive health and rights
6. Nipple-Sparing Mastectomies May Be Right for Some
7. Timing for clinical trials for stem cell therapy in spinal cord injuries is right
8. Americans Show Rising Support for Abortion Rights: Poll
9. Alcohol Affects Left, Right Heart Chambers Differently
10. Reconstruction Safe Right After Mastectomy: Study
11. Its Safe to Get IUD Right After Abortion, Miscarriage: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified CBD ... the mouth into the bloodstream. Far outpacing the absorption speed of ...
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine ... practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to ... number of neurosurgeons in Michigan performing minimally invasive back surgery that often results ...
(Date:2/22/2017)... CT (PRWEB) , ... February 22, 2017 , ... The ... and the 2017 Forecast —on Thursday, February 23, 2017, at 1:00 PM ET. A ... webinar is part of the Interactive Webinar Series. , If you want to find ...
(Date:2/22/2017)... ... February 22, 2017 , ... BrightStar Care Charleston , a home ... University of South Carolina (MUSC) Center on Aging’s Senior Expo on Thursday, March ... Aging is a tremendous resource in our community. We are thrilled to participate in ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... number of African American/Black students who want to become physicians. PMF also provides ... careers as physicians in the Oakland/San Francisco Northern California, Bay Area. PMF’s mission ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Kineta, Inc., a biotechnology ... immune modulating therapies, today announced that KCP-400 (RgIA4), ... receptor (nAChR), demonstrates robust chronic pain relief and ... study also establishes the a9a10 nAChR as a ... pain. The findings were reported online in the ...
(Date:2/22/2017)... and HAMBURG, Germany , February 22, 2017 ... precision oncology headquartered in Hamburg, Germany and ... research institution, announced today a collaboration to support the first Indian ... research. ... Indivumed signed an agreement with an initial three-year term. The collaboration ...
(Date:2/21/2017)... NEW YORK , Feb. 21, 2017 ... equipment with specialized versions are used to monitor physiological ... or as remote patient monitors. Remote patient monitoring is ... of the patient monitoring equipment in the market. Hence, ... integrated with smartphones and applications, which can send test ...
Breaking Medicine Technology: