Navigation Links
When your left hand mimics what your right hand does: It's in the genes
Date:2/17/2012

Further work carried out on mice suggests that this gene plays a part in motor network cross-over. Cross-over is a key factor in the transmission of brain signals, because it allows the right side of the brain to control the left side of the body and vice versa. This research has been published in The American Journal of Human Genetics.

Congenital mirror movement is a rare disease transmitted from one generation to another by dominant inheritance. The affected persons lose the ability to carry out different movements with separate hands: when one hand moves in a certain way, the other hand is "forced" to copy the same movement, even if the person does not wish to do so. So people suffering from this disease are totally incapable of bimanual motor activities, such as piano playing for example. This phenomenon has been observed in children, but generally cleared up spontaneously before the age of 10, no doubt due to maturing of the motoneuron networks. However, in people who are affected by the disorder, the illness starts in early childhood and remains unchanged throughout life.

In 2010, research scientists from Quebec analyzed the genome from the members of a large Canadian family and discovered a gene responsible for the disease. Mutations had been detected in the DCC (Deleted in Colorectal Carcinoma) gene. Following this discovery, the team of researchers and doctors coordinated by Emmanuel Flamand-Roze began to search for mutations in this gene in several members of a French family who were also suffering from congenital mirror movements disease, but without success. "The DCC gene was intact", explained Emmanuel Flamand-Roze. "We thought we were nearly there and instead we had to start searching for mutation in a different gene", he adds.

Using an approach that combines conventional genetic analysis and "whole exome" analysis (a new-generation genetic analysis technique that involves entirely sequencing the important part of the genome), scientists demonstrated that the RAD51 gene was responsible for congenital mirror movement disease in a large French family and went on to corroborate this result using the same techniques on a German family suffering from the same disorder.

"The RAD51 gene was already known to the scientific community as a potential catalyst for certain types of cancer and in problems of resistance to chemotherapy", explains Emmanuel Flamand-Roze. "So we wondered whether it had yet another function that could explain the motor symptoms of CMM disease".

In humans, the motor system is a cross-control system, which means that the left side of the brain controls the motor functions of the right side of the body and vice versa, with the cross-over taking place at the brainstem. While studying the expression of the RAD51 protein during development of the motor system in mice, the research scientists discovered that this gene could be implanted into the cross-over of the motor network that links the brain to the spinal fluid at the brainstem.

This discovery opens up a whole new field of investigation into the development of the motor system and to achieving better understanding of the cerebral mechanisms that control bimanual motricity. It could also shed light on other motricity disorders related to fine movement organization, such as dystonia or certain genetic neurodevelopmental diseases.


'/>"/>
Contact: Inserm Presse
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related medicine news :

1. Psychopaths Lack of Empathy Mimics Brain Injury: Research
2. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
3. Queens study shows the rights of people with disabilities are not being promoted
4. Dentist Gives Advice to Keep Holiday Smiles Bright
5. Good intentions may hamper progress in pursuit of global reproductive health and rights
6. Nipple-Sparing Mastectomies May Be Right for Some
7. Timing for clinical trials for stem cell therapy in spinal cord injuries is right
8. Americans Show Rising Support for Abortion Rights: Poll
9. Alcohol Affects Left, Right Heart Chambers Differently
10. Reconstruction Safe Right After Mastectomy: Study
11. Its Safe to Get IUD Right After Abortion, Miscarriage: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... 2016 , ... 10 Best Water is excited to announce a ... owners that topped the list as a result of their commitment to offering clients ... was Tibet 5100, a top notch water company that specializes in providing the public ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intalere’s 2016 Executive Forum, ... 200 of the country’s top healthcare executives to share insights on transformational strategies ... the Forum is the provider-centric perspective, experience, expertise and strategy shared by the ...
(Date:2/10/2016)... KALAMAZOO, MI (PRWEB) , ... February 10, 2016 , ... ... offer Apifiny® across their network of laboratory service centers across the country. ... designed to aid clinicians in the detection of prostate cancer. Apifiny order volume exceeded ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... will attend the Ohio Safety Congress and Expo event March 9-11, 2016. Hosted ... Greater Columbus Convention Center. , As the longest running and largest worker's ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Antibacterial Drugs Market - Global Industry Analysis, ... reveals that the global antibacterial drugs market is forecast to ... to patent expiries of blockbuster drugs. Even though the market ... period, the value is anticipated to decline from US$43.9 bn ... Antibacterial Drugs Market - Global Industry Analysis, Size, Share, Growth, ...
(Date:2/10/2016)... KANSAS CITY, Mo. , Feb. 10, 2016 ... the pharmaceutical industry, recently identified an industry-wide trend ... a tool that allows organizations to efficiently deliver ... surveys, one in 2011 and another in 2015, ... are armed with tablet devices and DSAs, many ...
(Date:2/10/2016)... Feb. 9, 2016 On Tuesday, ... (FDA) met with its Arthritis Advisory Committee ... of Johnson & Johnson,s Remicade and most ... in the U.S. The Biologics Prescribers Collaborative ... - Alliance for Patient Access, American Association ...
Breaking Medicine Technology: