Navigation Links
When will genomic research translate into clinical care -- and at what cost?
Date:1/4/2013

o which the examples used in the model will turn out to be representative of drugs as a whole. "It's a broad set of drugs that were used, but we know how the genome can surprise us," says senior author Sukhatme. "For example, you won't be able to use genomics to cut adverse outcomes in half if genomics turns out to explain less than half of the adverse outcomes. But even in that case, we found that pharmacogenomics will be able to make a significant dent in adverse outcomes cutting them by a quarter for multi-billion-dollar investments."

Also surprising, say the authors, was the timing. "As a rule, the fruits of research come only after research dollars have already been spent," points out Arnaout. This means that, in this case, hundreds of millions of dollars will be spent for "pump-priming" long before the public can expect to see any meaningful clinical impact. "It's one thing to say, 'Be patient,' based on just faith," he adds. "It's another to be able to say so based on data and a model. We now have that. This enables the conversation to shift to which indicators of progress to look for, over the five or so years of pump-priming, to make sure we're on track."

Can we go faster? "If we could enroll an ethnically diverse set of patients who are taking each of the 40 or 50 most commonly prescribed drugs, get their blood samples, and keep track of the adverse outcomes that some of them are bound to experience, we should be able to move faster, for less money," adds Arnaout, who describes this idea as a "50,000 Pharmacogenomes Project," a pursuit along the lines of the 1,000 Genomes Project, the UK10K or the Veteran's Association Million Veteran Program.

"This model provides the start of a provocative conversation and illustrates the value of quantitative modeling in this very practical and publically relevant aspect of genomics," adds BIDMC Chief of Pathology Jeffrey Saffitz, MD, PhD. "Such models should help both decision makers and the
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. NIH grant moves pathologists to the forefront of genomic medicine
2. Stanford/Yale study gives insight into subtle genomic differences among our own cells
3. Study shows large-scale genomic testing feasible, impacts therapy
4. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
5. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. $8.9 million NIH grant to study genomic link to premature heart disease
8. Study identifies genes associated with genomic expansions that cause disease
9. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
10. Genomic study of rare childrens cancer yields possible prognostic tool
11. Following the genomic pathways to stop the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... Beach, CA (PRWEB) November 23, 2014 ... of American Medical Aesthetics & Wellness was recently ... Asher Milgrom, Ph.D. is president and CEO of American ... Dr. Asher Milgrom received a full scholarship to ... and the Medical School at the University of Chicago, ...
(Date:11/23/2014)... 23, 2014 BambooFlooringChina.com , the world’s ... click strand woven bamboo flooring collection. Now, the business ... the company’s CEO, the promotion is valid until Dec. 20, ... with a smooth and dust-free surface, which makes it very ... the industry, the company wants to make its website the ...
(Date:11/22/2014)... November 23, 2014 PrettyTailor , ... with a new big promotion. Customers can buy new ... information, customers can visit its website. , As a ... and occasion dresses. It mainly provides four types of ... dresses and flower girl dresses. It also provides a ...
(Date:11/22/2014)... November 23, 2014 Today, Dylan Queen, ... new collection of wedding dresses; the business offers a ... related accessories for ladies worldwide, allowing them to create ... of the company, this new collection of chic wedding ... Moreover, they are offered at discounted rates now. Dylan ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Nocturia ... as the complaint that the individual has to ... voiding. The report “Nocturia – Pipeline Review, H2 ... for Nocturia, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ...
Breaking Medicine News(10 mins):Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 2Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 3Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 4Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4
... Today,s McCain Myth: John McCain would stand up ... The following release,was issued today by the Democratic ... John McCain says he will stand up ... the heart of American innovation, growth and,prosperity." But ...
... all pregnant women experience morning sickness - ... MorningSicknessHelp.com, "I was really sick in the beginning, and I thought, ,What the h--- have ... done?, - Marcia Cross, Morning ... 10 Oh Mama!, creator of the first,nutrition bar with DHA and engineered to meet ...
... Meaningful Measurement of Performance, ... from HealthLeaders-InterStudy, NASHVILLE, Tenn., June 10 ... reports the New York,Health Plan Association, in cooperation ... a statewide pay-for-performance (P4P),program for primary care physicians. ...
... to be led by SAP veteran, WAYNE, Pa., ... ICW Labs, a Silicon Valley based R&D organization,focused on ... its eHealth,solutions. ICW Labs will be headed by Thomas ... http://www.newscom.com/cgi-bin/prnh/20071126/NEM090LOGO ), The new ICW Lab is ...
... neuroscientists at UQ have discovered a new way to reduce ... disease. , Memory loss in people with Alzheimer,s disease ... a build-up of the neuro-toxin Amyloid beta the major ... and corresponding degeneration of a specific population of nerve cells ...
... helps them use online programs as well as drugs ... -- Insomnia among U.S. combat veterans returning from Iraq ... chronic insomnia, according to University of Pittsburgh researchers. , ... 14 insomnia patients and 14 good sleepers, and found ...
Cached Medicine News:Health News:Democratic National Committee McCain Myth Buster: John McCain and America's Small Businesses 2Health News:Democratic National Committee McCain Myth Buster: John McCain and America's Small Businesses 3Health News:Oh Mama! Heads Back to the Lab to Create the First Ever Ginger-Ale for Moms-To-Be 2Health News:Statewide Pay-For-Performance Program in Store for New York Physicians 2Health News:InterComponentWare Establishes ICW Labs 2Health News:QBI neuroscientists make Alzheimer's disease advance 2Health News:Combat Vets Display Severe Sleep Disorders 2
(Date:11/22/2014)... , 21 de noviembre de 2014 /PRNewswire/ ... ensayos clínicos externalizados y tecnologías eClinical, ha indicado ... de ,seguimiento inteligente, para el seguimiento basado en ... inteligente amplía el concepto del seguimiento basado en ... de las visitas de seguimiento o cambio de ...
(Date:11/22/2014)... Nov. 21, 2014  Particle Sciences, Inc (PSI), ... developed and manufactured a new innovative vaginal ring ... and Development arm of Exeltis Pharmaceuticals.  According to ... Management at Particle Sciences, "This vaginal ring was ... material sciences and modeling expertise.  We are thrilled ...
(Date:11/21/2014)... , Nov. 21, 2014  The University of ... host the ceremonial groundbreaking of the new A. James ... The new building will cultivate transformative new engineering and ... Taking place at 10:00 a.m. on November 21 ... Paint Branch Parking Lot, adjacent to the Jeong H. ...
Breaking Medicine Technology:El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3Particle Sciences' Clinical Trial Supplies Group Manufactures Innovative Vaginal Ring 2University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4
... MARLTON, N.J. , July 29 Free For All® ... Choice, Inc. today announced a plan to offer MMM/PMC members access to ... use of RxCut®Plus cards. , , ... The RxCut®Plus card works much like a traditional discount coupon that entitles ...
... , July 29 Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), ... quarter ended June 30, 2010 financial results on Thursday, August ... a live webcast and conference call at 5:00 p.m. Eastern time . ... Orexigen management will host the ...
Cached Medicine Technology:Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 2Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 3Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 4Orexigen® Therapeutics Schedules August 5, 2010 Webcast Discussion of Financial Results for the Second Quarter Ended June 30, 2010 2
... Flextend lead is a ... with an extendable/retractable active-fixation ... design offers various lead ... implantation in the atrium ...
... KY is a low profile implantable ... for stimulation of either the atrium ... is supplied with a screwdriver shape ... the lead. The ring tip and ...
... profile endocardial permanent pacing leads with an ... size of only 4.8 F and a ... Physique lead is the smallest extendable/retractable bipolar ... straight and pre-formed J configurations, Physique leads ...
Used to occupy an empty hole which is not being used in an implantablepacemaker header....
Medicine Products: