Navigation Links
When will genomic research translate into clinical care -- and at what cost?
Date:1/4/2013

o which the examples used in the model will turn out to be representative of drugs as a whole. "It's a broad set of drugs that were used, but we know how the genome can surprise us," says senior author Sukhatme. "For example, you won't be able to use genomics to cut adverse outcomes in half if genomics turns out to explain less than half of the adverse outcomes. But even in that case, we found that pharmacogenomics will be able to make a significant dent in adverse outcomes cutting them by a quarter for multi-billion-dollar investments."

Also surprising, say the authors, was the timing. "As a rule, the fruits of research come only after research dollars have already been spent," points out Arnaout. This means that, in this case, hundreds of millions of dollars will be spent for "pump-priming" long before the public can expect to see any meaningful clinical impact. "It's one thing to say, 'Be patient,' based on just faith," he adds. "It's another to be able to say so based on data and a model. We now have that. This enables the conversation to shift to which indicators of progress to look for, over the five or so years of pump-priming, to make sure we're on track."

Can we go faster? "If we could enroll an ethnically diverse set of patients who are taking each of the 40 or 50 most commonly prescribed drugs, get their blood samples, and keep track of the adverse outcomes that some of them are bound to experience, we should be able to move faster, for less money," adds Arnaout, who describes this idea as a "50,000 Pharmacogenomes Project," a pursuit along the lines of the 1,000 Genomes Project, the UK10K or the Veteran's Association Million Veteran Program.

"This model provides the start of a provocative conversation and illustrates the value of quantitative modeling in this very practical and publically relevant aspect of genomics," adds BIDMC Chief of Pathology Jeffrey Saffitz, MD, PhD. "Such models should help both decision makers and the
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. NIH grant moves pathologists to the forefront of genomic medicine
2. Stanford/Yale study gives insight into subtle genomic differences among our own cells
3. Study shows large-scale genomic testing feasible, impacts therapy
4. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
5. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. $8.9 million NIH grant to study genomic link to premature heart disease
8. Study identifies genes associated with genomic expansions that cause disease
9. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
10. Genomic study of rare childrens cancer yields possible prognostic tool
11. Following the genomic pathways to stop the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Mountain View, CA (PRWEB) July 29, 2014 ... officially released a new product called BNatrl Silver ... said Lis Herrey, CEO and spokesperson for BNatrl LLC. ... and your loved ones from harmful pathogens and microbes.” ... renewable energy, and clean water products, with 10 percent ...
(Date:7/29/2014)... Regents Health Resources, a consulting firm traditionally ... care industry veteran Daryl Demonbreun and former St. Thomas ... company’s ambitious plans to grow into a full-service health ... along at a steady pace for nearly 20 years, ... says Bob Maier, founder and chief executive officer of ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 According ... Market by Type (Swipe And Area), Material (Optical ... Government, Defense, Healthcare, Commercial Security and Banking & ... to 2014 - 2020", published by MarketsandMarkets, the ... $14.35 Billion by 2020, growing at a high ...
(Date:7/29/2014)... This Latest Guidebook for Conducting Pharma Clinical ... not only provided a comprehensive and thorough knowledge of ... drug registration but also introduced the practical operation how ... to use the Chinese trial venues to keep drug ... by step. , The audiences of this guidebook are ...
(Date:7/29/2014)... There is controversy over how best to treat patients ... one wait until the cancer comes back or provide ... Now, a new study from Thomas Jefferson ... doctors and patients make a more informed decision. , ... says first author Robert Den, M.D., Assistant Professor of ...
Breaking Medicine News(10 mins):Health News:BNatrl Launches New Silver Solution Product 2Health News:Sferrella and Demonbruen Join Regents Health Resources 2Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 2Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 3Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 4Health News:Pharma Clinical Trials Market in China: Authorities for Drug New Study Now Available at MarketReportsOnline.com 2Health News:Pharma Clinical Trials Market in China: Authorities for Drug New Study Now Available at MarketReportsOnline.com 3Health News:Pharma Clinical Trials Market in China: Authorities for Drug New Study Now Available at MarketReportsOnline.com 4Health News:Genomic analysis of prostate cancer indicates best course of action after surgery 2
... LANSING, Mich., Dec. 30 Neogen Corporation,(Nasdaq: NEOG ) announces the ... Quarter Results Webcast, When: Tuesday, January 6, 2009 ... How: Live over the Internet -- Simply log on to ... above., Contact: Terry Maynard of Neogen ...
... for Nearly 20% of 45 plus PopulationCHICAGO, Dec. 30 ... be your health. According to a recent AARP ... are suffering health problems due to financial stress. ... many Americans are facing because of the current economic ...
... - Stubbing Out Your 5 a Day Habit ... , Leading Child Trust Fund provider, ... decide,to give up smoking as their New Year,s resolution to ... futures. , According to figures from ...
... New Year,s resolutions often include being more careful, ... behavior, such as drug use. But new research ... seekers by psychologists--face an uphill battle in keeping ... their brains process dopamine. The research reveals that ...
... Committee for Quality,Assurance and the American Diabetes Association ... Barnett, M.D., Mirela Sturzu,M.D., Rudolf Teschan, M.D., and ... Recognition Program for providing quality care to,patients with ... and Zaki practice at the Aurora Health Center, ...
... CORONA, Calif., Dec. 29 Watson Pharmaceuticals,Inc. (NYSE: ... and specialty branded pharmaceuticals,today announced that its subsidiary, ... United States Food and Drug Administration on its,Abbreviated ... estradiol tablets USP, 0.15 mg / 0.02 mg. ...
Cached Medicine News:Health News:Economic Stress Taking Toll on Peoples' Health 2Health News:Urging New Year Quitters to Invest in Their Family's Futures 2Health News:Risk takers, drug abusers driven by decreased ability to process dopamine 2Health News:Aurora Physicians Receive National Recognition for Quality Diabetes Care 2Health News:Watson Pharmaceuticals Receives FDA Final Approval for Generic Mircette(R) 2
(Date:7/29/2014)... 2014   Health 2.0 announces Bernard Tyson ... physicians Eric Topol , Patrick Soon-Shiong , and ... 2.0 8th Annual Fall Conference this coming Sept. 21-24 ... Health 2.0 is set to host the very first Wearable ... on Consumer Tech & Wearables: Powering Healthy Lifestyles. ...
(Date:7/29/2014)...   , First patient ... efficacy and safety of MSB0010718C in patients with metastatic Merkel ... aggressive skin cancer lacking effective treatments   MSB0010718C is ... clinical trial for the treatment of solid tumors that aims ... a subsidiary of Merck KGaA, Darmstadt, Germany ...
(Date:7/28/2014)... , July 28, 2014  Dignity Health ... has received the Get With The Guidelines®-Stroke Silver-Plus ... measures outlined by the American Heart Association/American Stroke ... is the number four cause of death and ... the United States , according to ...
Breaking Medicine Technology:Kaiser Permanente CEO to Keynote Health 2.0 8th Annual Fall Conference 2Kaiser Permanente CEO to Keynote Health 2.0 8th Annual Fall Conference 3EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 2EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 3EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 5Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3
... --Could Become First Effective Drug for Rare Genetic ... have used,a drug to achieve normal levels of ... high insulin levels. If this approach,succeeds in humans, ... congenital hyperinsulinism, a rare but potentially devastating genetic,disease ...
... First to Receive FDA, Clearance for Diagnosis of Uncertain Tumors; ... ... July 31 Pathwork Diagnostics, Inc.,a molecular diagnostics company focused on ... cleared its Pathwork(R),Tissue of Origin Test for use in determining the ...
Cached Medicine Technology:Treatment Corrects Severe Insulin Imbalance in Animal Studies 2Treatment Corrects Severe Insulin Imbalance in Animal Studies 3FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 2FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 3FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 4
... NEAR-SkinT™ Incise Drapes have aggressive ... permeability for extended adhesion. It's made ... for unsurpassed conformability with allow-glare matte ... identification. , ,Available sterile in ...
The Quantum II Dual Wavelength Analyzer measures differential absorbances of liquid samples and converts those readings into analytical values....
... The HYBrite Hybridization System - the hands-free ... Procedures. Now performing fluorescent in situ hybridization ... ever before. HYBrite is the first rapid, ... FISH procedures. Now you can have a ...
... CELL-DYN 4000 uses the power of ... parameters to the hematology laboratory. Fluorescent ... random-access reticulocyte results. Fluorescent DNA staining ... accurate white blood cell values and ...
Medicine Products: