Navigation Links
When will genomic research translate into clinical care -- and at what cost?
Date:1/4/2013

genomics is really starting to change things, but it's been hard to know how it all adds up in the big picture," explains Arnaout, who is also an Assistant Professor of Pathology at Harvard Medical School (HMS) and Associate Director of Clinical Microbiology at BIDMC. "Quantitative modeling is a standard approach for forecasting and setting expectations in many fields as we all remember from the recent presidential election and from the hurricane season. Genomics is so important and is so often on the minds of our patients, students and staff, that it seemed like a good idea to use modeling to get some hard numbers on where we're headed."

The idea for the study originated nearly two years ago, while Arnaout (whose laboratory studies genomics) and Sukhatme, BIDMC's Chief Academic Officer, were attending a lecture, shortly after the 10-year anniversary of the sequencing of the genome. "Vikas asked me, 'So when is genomics really going to change medicine?'" remembers Arnaout. "I realized I didn't know. And that got me thinking."

Arnaout and Sukhatme, together with coauthors Thomas Buck, MD, and Paulvalery Roulette, MD, of BIDMC and HMS, decided to try and answer this question by applying forecasting methods to a big clinical problem drug-related adverse outcomes. "We know that preventable causes of these adverse outcomes -- patients' non-adherence, interactions between multiple drugs, and medical error, for example -- account for only a fraction of the millions of adverse outcomes that patients experience each year," explains Arnaout. "This leaves a significant number that are currently considered non-preventable and are thought to be caused by genomic variation."

By way of example, Arnaout explains that 30 million Americans currently use the blood-thinning drug warfarin. But because, in some cases, patients' genomes contain variants that make the standard dose of warfarin too high for them, these individuals are likely to experience bleedi
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. NIH grant moves pathologists to the forefront of genomic medicine
2. Stanford/Yale study gives insight into subtle genomic differences among our own cells
3. Study shows large-scale genomic testing feasible, impacts therapy
4. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
5. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. $8.9 million NIH grant to study genomic link to premature heart disease
8. Study identifies genes associated with genomic expansions that cause disease
9. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
10. Genomic study of rare childrens cancer yields possible prognostic tool
11. Following the genomic pathways to stop the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Ticket Down is a reputable source for authentic tickets for ... phenomenal and highly successful live tour last year, the cast of ... again in 2015 and they will be visiting 8 cities along ... New York City at the cozy Beacon Theatre and will wrap ... , Fans of the hit show can look forward to seeing ...
(Date:3/27/2015)... Dallas, TX (PRWEB) March 27, 2015 ... Landscape – Germany” is an essential source of ... and reimbursement landscape in Germany. Germany’s increasingly elderly ... drivers of its pharmaceutical market. In 2013, the ... expected to increase at Compound Annual Growth Rate ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 While deep learning ... 2015 GPU technology conference (GTC) , the CEO of one ... and push the human lifespan well beyond the generally-agreed ceiling ... informatics company , is one of 12 companies recognized as ... other startups in the GTC Emerging Companies Summit ...
(Date:3/27/2015)... NE (PRWEB) March 27, 2015 Ticket Down ... at the CenturyLink Center in Omaha, Nebraska on Friday, ... possibility that more concert dates will be added in Omaha ... of fan demand. , The Garth Brooks World Tour is ... the latest announcement that Garth Brooks and Trisha Yearwood will ...
(Date:3/27/2015)... According to a recently published report series by ... market in Europe is in decline due to decreasing ... Price decreases are being seen across the entire orthopedic ... total European trauma device market, continued pricing pressure overall ... after year. , “Such price drops are typical ...
Breaking Medicine News(10 mins):Health News:Nashville Live in Concert Tickets in New York, Boston, Washington, DC, Chicago, Minneapolis, San Francisco, Los Angeles and Phoenix Now On Sale at TicketDown.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 2Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 3Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 3Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3
... minor ... problem,- 57% are unaware that diaper rash can be accompanied by a doctor ... - 59% responded "no" or were unsure when asked if there was a connection ... between diaper rash and antibiotics, PRINCETON, N.J., June 17 Barrier,Therapeutics, Inc. (Nasdaq: ...
... 17 Gentiva Health,Services, Inc. (Nasdaq: GTIV ), ... today that it is scheduled to,present from 1:00 to ... Jefferies,2nd Annual Healthcare Conference in New York., The ... live audio web,cast, which may be accessed by visiting, ...
... bullet, to help miilions of children in developing ... -- A new compound that may lead to an ... researchers at the University of Texas Health Science Center ... important for developing countries, where diarrhea is a major ...
... UK and Philadelphia, US June 17, 2008 ... biopharmaceutical company, today announced the publication of data from ... of ulcerative colitis (UC) drug Lialda™ (mesalamine). The primary ... and tolerability of Lialda in mild-to-moderate UC patients over ...
... CHICAGO, June 17 U.S. Environmental,Protection Agency Region 5 this ... hazards from underground soil contamination in,St. Louis Park, Minn., ... and,businesses are scheduled for July 10, 2 to 4 p.m. ... High School cafeteria, 6425 W. 33rd St. EPA,s,storefront office at ...
... be released at AHIP Institute July 18-20, ... from,URAC provides answers for health plans and health ... new trends in outsourcing of,credentialing services., (Logo: ... become available during the AHIP Institute, June 18-20,in ...
Cached Medicine News:Health News:Vusion Baby Bottom Line Report: Many Moms Don't Know that Their Babies' Irritated Skin Could Indicate a Severe Diaper Rash that Requires Medical Treatment 2Health News:Vusion Baby Bottom Line Report: Many Moms Don't Know that Their Babies' Irritated Skin Could Indicate a Severe Diaper Rash that Requires Medical Treatment 3Health News:Vusion Baby Bottom Line Report: Many Moms Don't Know that Their Babies' Irritated Skin Could Indicate a Severe Diaper Rash that Requires Medical Treatment 4Health News:Gentiva(R) Health Services to Present June 24 at Jefferies' 2nd Annual Healthcare Conference in New York 2Health News:Gentiva(R) Health Services to Present June 24 at Jefferies' 2nd Annual Healthcare Conference in New York 3Health News:Inexpensive Compound Could Treat Severe Diarrhea 2Health News:Long-term safety data on Lialda published in leading GI journal 2Health News:Long-term safety data on Lialda published in leading GI journal 3Health News:St. Louis Park Vapor Systems Installation Nearly Complete; Meeting July 10 2Health News:New URAC Issue Brief Answers Questions About Delegated Credentialing, Transparency in Physician Tiering Programs 2Health News:New URAC Issue Brief Answers Questions About Delegated Credentialing, Transparency in Physician Tiering Programs 3
(Date:3/26/2015)... , March 26, 2015 Over-the-counter healthcare ... American consumer. However, a new survey of store ... from the common cold to diabetes, can offer ... research, conducted by the Private Label Manufacturers Association, ... healthcare products, including those essential for treatment of ...
(Date:3/26/2015)... -- A new survey of health care stakeholders ... will yield improvements in health care decision-making, but ... CER in the current environment. The National Pharmaceutical ... that they view CER as important, expect it ... decision-making in the next three to five years, ...
(Date:3/26/2015)... 26, 2015  Desert Valley Medical Center, named a ... is the first U.S. hospital to deploy the ... to help clinicians prevent hospital acquired pressure ulcers. ... , is a community hospital serving some higher ... Leaf Patient Monitor in the hospital,s emergency department enables ...
Breaking Medicine Technology:Consumers can keep over-the-counter medicine affordable by using store brands 2NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 2NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 3NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 4Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 2Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 3
... 2011 Sevocity, the leader in cloud-based Electronic ... achieved full certification through the Certification Commission for ... Certified® 2011 Ambulatory EHR.  Sevocity v11.1 also achieved ... level awarded by CCHIT.  The Certification Commission for ...
... -- 3SBio Inc. (NASDAQ: SSRX ) ... company focused on researching, developing, manufacturing and marketing ... Food and Drug Administration ("SFDA") has approved its ... treatment of anemia associated with chemotherapy in cancer ...
Cached Medicine Technology:Sevocity Division of Conceptual MindWorks Inc.'s Sevocity EHR Earns CCHIT 2011 Certification 23SBio Inc. Announces SFDA Approval of High-Dose EPIAO 23SBio Inc. Announces SFDA Approval of High-Dose EPIAO 33SBio Inc. Announces SFDA Approval of High-Dose EPIAO 4
... Acid powder reagent once reconstituted offers the ... stability to help maximize laboratory productivity, minimize ... time. The proprietary technology of the Infinity ... shelf life and stability once reconstituted that ...
... Glucose Oxidase single liquid stable reagent ... of single liquid stability to help ... and provide quick result turnaround time. ... Glucose Oxidase reagent provides a long ...
... reagent is intended for the in ... serum. , Infinity Cholesterol powder reagent ... stability once reconstituted and convenience, but ... existing assays. The reagent is suitable ...
...
Medicine Products: