Navigation Links
When will genomic research translate into clinical care -- and at what cost?
Date:1/4/2013

BOSTON Genomic research is widely expected to transform medicine, but progress has been slower than expected. While critics argue that the genomics "promise" has been broken and that money might be better spent elsewhere -- proponents say the deliberate pace underscores the complexity of the relationship between medicine and disease and, indeed, argues for more funding.

But thus far, these competing narratives have been based mostly on anecdotes. Ramy Arnaout, MD, DPhil, a founding member of the Genomic Medicine Initiative at Beth Israel Deaconess Medical Center (BIDMC), decided it was time to look at genomics from a new perspective. So he turned to quantitative modeling, a numerical forecasting approach used to predict everything from weather events to the outcomes of political elections, and an extremely useful way to both set expectations and assist in decision-making.

Arnaout and colleagues knew that drug-related adverse outcomes cost the health-care system upwards of $80 billion a year, and that many such cases should be avoidable by choosing and dosing drug prescriptions according to a person's genome. So they developed a quantitative model to estimate how much time and money would be required to use genomics, specifically pharmacogenomics, to cut these adverse outcomes in half. Their findings, currently published online in the journal Clinical Chemistry, provide one of the first examples of data-driven estimates being applied to genomic medicine and offer a template for the use of quantitative modeling in this field.

How do the numbers add up? After analyzing their model for a range of situations, the research team found that the cost can be expected to be less than $10 billion, spread out over approximately 20 years.

"If you look across medicine, you can see specific places here and there where
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. NIH grant moves pathologists to the forefront of genomic medicine
2. Stanford/Yale study gives insight into subtle genomic differences among our own cells
3. Study shows large-scale genomic testing feasible, impacts therapy
4. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
5. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. $8.9 million NIH grant to study genomic link to premature heart disease
8. Study identifies genes associated with genomic expansions that cause disease
9. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
10. Genomic study of rare childrens cancer yields possible prognostic tool
11. Following the genomic pathways to stop the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... UT (PRWEB) June 19, 2013 ... , In July 2013, Orriant is launching a ... rates, and maintain compliance with regulations. New ... to receive wellness incentives if their employer offers ... they have been compliant with these standards for ...
(Date:6/19/2013)... Citi Bike has come to New York City in a ... know for sure how many patients will choose to take advantage ... option. In fact, he’s happy about anything that might help ... more convenient for them to visit his office at 133 East ... Medicine at Back and Body Medical and an experienced NYC ...
(Date:6/19/2013)... trauma surgery have had a significant impact on ... major injuries, including burns. Patients who survive ... at greatest risk from infections particularly the ... or from inflammation-induced multiorgan failure. Now, a ... that measures the movement of key immune cells ...
(Date:6/19/2013)... The results of three important studies have been published ... journal of the Congress of Neurological Surgeons . ... & Wilkins , a part of Wolters Kluwer ... learning" using artificial neural networks (ANNs) may improve the ... cancers. Another study in the June Neurosurgery ...
(Date:6/19/2013)... available in Spanish . ... diseases, it goes by the name of the 10/90 gap: ... to conditions that accounted for 90 per cent of the ... the Drugs for Neglected Diseases initiative (DNDi) came into being ... has been granted the BBVA Foundation Frontiers of Knowledge Award ...
Breaking Medicine News(10 mins):Health News:New Tool to Increase Participation Rates for Corporate Wellness Programs in July 2013 Will Help Maintain Compliance with Federal Regulations 2Health News:New Tool to Increase Participation Rates for Corporate Wellness Programs in July 2013 Will Help Maintain Compliance with Federal Regulations 3Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 2Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 3Health News:Restoring appropriate movement to immune cells may save seriously burned patients 2Health News:Restoring appropriate movement to immune cells may save seriously burned patients 3Health News:Neurosurgery publishes findings of 3 important studies in June issue 2Health News:Neurosurgery publishes findings of 3 important studies in June issue 3Health News:DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation 2Health News:DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation 3Health News:DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation 4Health News:DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation 5
... could be signs of flu. These days, people fear the symptoms ... wait in hours-long lines to get a shot of influenza vaccine ... panic. "We're getting a tremendous amount of calls and a tremendous ... County Health Department in upstate New York. "People are anxious to ...
... whether people with aches and coughs have the ominous first signs ... have runny noses. In general, the first symptoms of inhaled anthrax ... fever, ache, cough, no energy. // ,As a result, ... which do nothing for colds and flu -- just to make ...
... go to bed early to be ready for a big test ... study to be released Friday by a San Fernando Valley researcher ... // , REM sleep is a deep sleep during ... body is almost completely paralyzed except for the heart, diaphragm, eye ...
... time and improve performance for military servicemen who must perform ... periods of time, according to a new report by the ... of Medicine, found that 100 to 600 mg of caffeine, ... help "maintain cognitive performance," especially in times of sleep deprivation. ...
... American doctors, there is no upper age limit to the ... for detecting bowel cancer and polyps before any symptoms develop. ... a faecal occult blood test (FOBT), sigmoidoscopy or colonoscopy - ... a family history of colon cancer. // ,But it ...
... which may allow the early detection of all forms of ... a cholesterol test, the 'C-Test' will be evaluated in a ... is based on scientific work by the John Baskin's School ... Rodrigues Pat, leader of the research team, said the blood ...
Cached Medicine News:Health News:Detection of Cancer 2
(Date:6/19/2013)... June 19, 2013 The Physician-Patient Alliance for Health ... The need to urgently address this issue has ... Event Alert #50 , "Medical device alarm safety in hospitals." ... January 2008 and June 2012, there were 98 alarm related ... death (82%) , 13 resulted in permanent loss of ...
(Date:6/19/2013)... June 19, 2013   BioCision , a ... and handling in many areas of medical and ... patents by the U.S. Patent Office that apply ... to standardize sample handling to ensure the consistency ... common laboratory procedures. Patent number ...
(Date:6/19/2013)... 19, 2013 ... DrugPatentWatch to its extensive list of ...      (Logo: http://photos.prnewswire.com/prnh/20130128/590935) , ... pharmaceutical, drug patents and their expirations. ... business functions of patent agents and ...
Breaking Medicine Technology:Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 2Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 3BioCision Announces Two New U.S. Patents for Thermo-Conductive Products that Standardize Sample Handling in Laboratory Research 2Drug Patent Watch 2Drug Patent Watch 3
... of three test plates(6mm, 3mm, and 1.5mm thick), ... of 600 - 15 seconds. No special glasses ... detected if stereopsis is present. Test plates can ... patient learning the correct answer. Large stereo acuity ...
8 X 1 Red Filter. Color Filters are designed to filter out all other color regions of the visible spectrum except the specified color. Color Filters are excellent for contrast enhancement and color r...
Last 3-6 months average refrigeration will prolong life. Pupil gauge printed on penlight 4 1/2" long 1/2" around....
Doctors six-pack long lasting, disposable, diagnostic penlights. Constant use time of 30 minutes. One year shelf life warranty from date of purchase. Convenient clip-activated switch & imprinted medi...
Medicine Products: