Navigation Links
When should prostate-specific antigen testing be stopped?
Date:2/19/2009

New York, NY, February 20, 2009 Although widespread Prostate-Specific-Antigen (PSA) testing has undoubtedly decreased prostate cancer mortality, is there a point of diminishing returns? In a study published in the April 2009 issue of The Journal of Urology, researchers found that in a subgroup of elderly men, among those who were 75 years old or older and had a PSA below 3 ng/ml (nanograms per milliliter), none subsequently died of prostate cancer. The discontinuation of routine PSA screening in these men may not increase the rates of undetected lethal disease, and could avoid potentially unnecessary treatments and reduce diagnostic costs.

Because PSA screening can find cancers that may become life-threatening in 5 to 25 years, there has been increased usage of the test in 40 to 50-year-olds. But the test can also discover cancers that never become life-threatening, perhaps in up to 30% of the cases. Many men who are older than 75 undergo continued PSA screening, potentially leading to unnecessary treatment since death from other causes is more likely than death from prostate cancer.

The study conducted by investigators from the Baltimore Longitudinal Study of Aging (National Institute on Aging, National Institutes of Health) and the Department of Urology at Johns Hopkins School of Medicine involved 849 men (122 with and 727 without prostate cancer) with serial PSA measurements . Researchers found that for men over 75 with PSA < 3ng/ml, none died of prostate cancer and only one developed high-risk prostate cancer. In contrast, men of all ages with a PSA ≥3.0 ng/ml had a continually rising probability of death from prostate cancer.

Writing in the article, Edward M. Schaeffer states, "The optimal approach to prostate cancer screening remains controversial. To date, there is limited evidence from which to inform the decision on when to discontinue prostate cancer screening. Our findings suggest that men at an age of 75-80 years who have a PSA level below 3ng/ml are unlikely to be diagnosed with a high risk prostate cancer during life. These men may therefore represent an ideal target group for discontinuation of PSA testing, which could dramatically reduce the costs associated with screening and the potential morbidity of additional evaluations and/or treatment in a population unlikely to gain benefit." Dr. Schaeffer emphasized that these findings need to be confirmed in a much larger study, and that men over the age of 75 years should continue to be monitored for development of clinical signs of prostate cancer.


'/>"/>

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Should intra-abdominal pressure measurement be a routine for all pancreatitis patients?
2. National Pharmaceutical Council on Economic Stimulus Package: Comparative Effectiveness Research Funding Should Target Improvements in Quality of Patient Care
3. Force Tester Shoulders The Burden
4. Contact Lens Wearers Should Blink More Often During Winter - Tips from VisionDirect.com to Keep Eyes Moist During Dry Winter Months
5. Virginia Leaders Should Reject Flawed Smoke-Free Legislation That Fails to Protect Everyones Right to Breathe Clean Air
6. Alternative and complementary medicine should have role in new era of health care reform
7. Alternative and Complementary Medicine Should Have Role in New Era of Health Care Reform
8. Pictures Say a Thousand Words... No American Should Lack Access to Affordable, Comprehensive Health Services
9. Three-Quarters of Americans Believe Health Insurance Should Pay for Addiction Treatment, Yet Most Dont Know If Their Health Plan Covers Substance-Abuse Care, Says New Hazelden Survey
10. Quick Orthopedic Repair Can Save Young Shoulders
11. Immediate Orthopaedic Care Can Help Heal a Young Athletes Shoulder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... , ... May 21, 2017 , ... ... it's been longer than six months since you've seen a dentist, it's time ... per year and getting x-rays once per year. , Dental checkups are a ...
(Date:5/19/2017)... ... May 19, 2017 , ... When Kyle Busch graduates ... name will already appear on two major research studies that could impact the health ... Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an international team trying ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... class of Beckman Young Investigators: , Victor Acosta, Ph.D. - University of New ... Dan Fu, Ph.D. - University of Washington, Erik Grumstrup, Ph.D. - Montana Stata ...
(Date:5/19/2017)... ... May 18, 2017 , ... CloSYS products which are marketed as the gentle ... for mouth and gum health, which is linked to one’s overall health. Since 1991 ... of the powerful ways in which CloSYS products immediately helped eliminate bad breath as ...
(Date:5/18/2017)... ... May 18, 2017 , ... Originally launched to market as the ... Tab. Due to the rapid expansion of their product line, the company believed it ... Now, the HighQ brand will be any tablet product sold by EPIK Learning. ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017 Radiology has become the number ... have also spiraled to the number one ranking as ... than ever before as the most complete and reliable ... with lower back pain an MRI may confirm a ... pain, resulting in entirely different treatment protocols.  In these ...
(Date:5/9/2017)... , May 9, 2017  Semler Scientific, ... provides technology solutions to improve the clinical effectiveness ... results for the first quarter ended March 31, ... products enable our customers to identify when preventive ... intervene before events like heart attacks or strokes ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology: