Navigation Links
When seconds count: Interventional radiology treatment for pulmonary embolism saves lives
Date:11/11/2009

FAIRFAX, Va.Catheter-directed therapy or catheter-directed thrombolysisan interventional radiology treatment that uses targeted image-guided drug delivery with specially designed catheters to dissolve dangerous blood clots in the lungssaves lives and should be considered a first-line treatment option for massive pulmonary embolism, note researchers in the November Journal of Vascular and Interventional Radiology.

"Modern catheter-directed therapy for acute pulmonary embolism saves lives, and we need to raise awareness about its safety and effectiveness not only among the general public but also within the medical community. It's a matter of life and death," said William Kuo, M.D., an interventional radiologist who is assistant professor and fellowship director of vascular and interventional radiology in the Department of Radiology at Stanford University Medical Center in Stanford, Calif. "In our study, we conclude that modern catheter-directed therapy is a relatively safe and effective treatment for acute massive pulmonary embolism and should be considered as a first-line treatment option," he added.

Pulmonary embolism occurs when one or more arteries in the lungs become blocked from blood clots that break free and travel there. These clots most often begin as deep vein thrombosis (DVT) or blood clots within the deep leg veins. When the clots break free, circulate and become trapped in the lungs, they can block the oxygen supply, cause heart failure and result in death. About 600,000 cases of acute pulmonary embolism are diagnosed each year in the United States, and an estimated 300,000 patients die, noted Kuo. "If initiated early, minimally invasive catheter-directed therapy could save many of those lives," added the lead author of the study, "Catheter-directed Therapy for the Treatment of Massive Pulmonary Embolism: Systematic Review and Meta-analysis of Modern Techniques."

During the treatment, an interventional radiologist inserts specially designed catheters (thin plastic tubes) through a tiny incision into one's blood vessels and guides the catheters using real-time imaging without traditional open surgery. This allows an interventional radiologist to deliver a clot-busting medicine directly into the clot. The catheters may also be used to mechanically break up clots and suction them away. This treatment offers less pain and less recovery time than traditional open surgery, said Kuo.

Stanford University researchers conducted a meta-analysis of the treatment on 594 patients in 18 countries who were treated between 1990 and 2008. The treatment was lifesaving in 86.5 percent of the cases studied and had only a 2.4 percent chance of major complications. Researchers found that not only was the treatment effective, but it also appeared much safer than the historical complication rates reported from injecting high-dose clot-busting medicine systemically or directly into the blood stream where the drug can circulate throughout the body and cause major bleeding in up to 20 percent of patients.

Kuo began this study three years ago after he was asked to assist with a 62-year-old woman who had collapsed at home and was rushed to the emergency room with massive blood clots in her lungs. The patient had been given a large-dose intravenous infusion of clot-busing medicine, a treatment called systemic thrombolysis, but that had failed.

While Kuo was initially consulted to place a special filter to prevent more clots from traveling from the legs to the lungs, he knew it would do little to save her. "I could see that she was quickly dying and there was no time to waste. I remember telling the staff, 'We can do more than just insert a filter. We can go after these clots using specially designed catheters,'" said Kuo. After obtaining consent from the family, Kuo made a tiny incision into the patient's neck and inserted a catheter into the vein. He then used X-ray images (fluoroscopy) to guide the catheter, navigating through the heart and finally reaching the blood clots within the lungs. He injected a clot-busting drug directly into the clots and then used the catheter to mechanically break up the clots before suctioning them out. "The results were immediate, and the treatment saved her life," said Kuo. "That experience inspired me to initiate further studies and to raise awareness of this emerging life-saving procedure," he added.

According to Kuo, the study addressed the use of catheter-directed therapy for treating the most severe or life-threatening form of pulmonary embolism known as "massive" pulmonary embolism. Additional studies are needed to see if the treatment should be initiated in those patients with less severe or "sub-massive" pulmonary embolism, he added. To answer these questions and to analyze further treatment outcomes, Kuo's team is initiating the multicenter PERFECT (Pulmonary Embolism Response to Fragmentation, Embolectomy and Catheter Thrombolysis) registry. In the meantime, the Stanford researchers advocate the use of catheter-directed therapy for massive pulmonary embolism "as both an early and alternative treatment option at centers with the appropriate expertise," said Kuo.


'/>"/>

Contact: Maryann Verrillo
mverrillo@SIRweb.org
703-460-5572
Society of Interventional Radiology
Source:Eurekalert

Related medicine news :

1. Sixty Seconds That Can Change Your Life
2. 11 Minutes or 90 Seconds?
3. Expanded Seconds-Count.org Helps Physicians Navigate Spectrum of Cardiovascular Disease Treatment Options
4. Alzheimers Strikes Every 71 Seconds! Carefree Senior Living Press Releases New Book: What the Heck Do We Do Now? Families Facing Alzheimers
5. Every 30 Seconds an African Child Dies from Malaria; Education Key to Prevention
6. Only 10 Seconds to Care by Dr. Wendy S. Harpham helps heal clinician-patient bonds
7. SCAI and ACC announce new interventional cardiology meeting
8. Gorilla Receives State-Of-The-Art Treatment for Uterine Fibroids from Interventional Radiologists
9. Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System
10. Siemens Introduces Its New Generation of Artis Interventional Imaging Systems
11. SCAI Announces New Program to Support Interventional Cardiology Training Fellowships
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
Breaking Medicine Technology: