Navigation Links
When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs
Date:5/23/2013

ted by phosphorylated AGO2, including miR-31, miR-192 and miR-193a-5p, also shared a long-loop structure in their precursors that miRNAs unaffected by AGO2 phosphorylation lack.

Hypoxic environments around tumors promote metastasis by helping cells evade programmed cell death. Hung and colleagues showed that EGFR-mediated AGO2 phosphorylation blocks cell death and enhances invasiveness under hypoxia.

Experiments in a mouse model of breast cancer confirmed that expression of EGFR and the presence of phosphorylated AGO2 increase during tumor progression under oxygen-starved conditions.

EGFR-AGO2 connection found in human breast tumors; reduces survival

The hypoxia-EGFR-AGO2 connection was strong in tumor samples from 128 breast cancer patients, but it was low or absent in normal breast tissue. In 125 breast cancer cases analyzed by the team, half of 62 patients with high levels of phosphorylated AGO2 survived to 48 months and beyond. Median survival had not been reached for the 63 patients in the low-level group, but 78 percent had survived to 48 months.

"One can imagine other receptors for platelet-derived growth factor and insulin-like growth factor also regulating miRNAs, perhaps by regulating Dicer or TBRP," Hung said. "This is a turning-point paper; it will induce lots of new questions for scientists to pursue."


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Low oxygen levels could drive cancer growth
2. Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
3. Should oxygen be used for patients with chronic heart failure?
4. Cooling Helps Oxygen-Deprived Newborns: Study
5. New anti-inflammatory drugs pinch off reactive oxygen species at the source
6. Lack of oxygen in cancer cells leads to growth and metastasis
7. COPD patients experience poorer sleep quality and lower blood oxygen levels
8. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
9. Study finds association between oxygen deprivation before birth and ADHD
10. Oxygen Deprivation in the Womb May Raise ADHD Risk
11. Oxygen Treatment May Improve the Odds for Extreme Preemies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Losing Weight Your Body’s Way , In ... in the face, it certainly can be difficult to choose ... an extra favor by doing it the healthy way? Set ... listen to your body, exercise regularly, and choose foods with ... losing weight; you need to exercise more and eat less. ...
(Date:10/22/2014)... By Steven Reinberg ... -- Infants who quickly add weight and length may be ... study suggests. In adults, certain genes have been linked ... promote proportionate gains in fat and lean muscle, the researchers ... be heavier and taller. By ages 2 and 3, however, ...
(Date:10/22/2014)... -- Measures taken by Firestone officials at the company,s ... limited the spread of the disease there and could ... Rubber Co. provides health services to about 80,000 employees, ... communities. Between Aug. 1 and Sept. 23, there ... 80,000 people. That incidence rate of 0.09 percent was ...
(Date:10/20/2014)... PA (PRWEB) October 20, 2014 Allegheny ... minimally-invasive procedure that enables physicians to repair a damaged ... The MitraClip system, developed by Abbott ... (MR), a progressive and life-threatening condition in which the ... blood to flow backward from the heart’s left ventricle ...
(Date:10/20/2014)... 20, 2014 hc1.com today announced ... cloud solution that enables healthcare organizations of all ... healthcare-specific customer relationship management (“CRM”) solution. , Designed ... needs of the healthcare industry, the hc1 Healthcare ... and patients by combining healthcare CRM, HIPAA-compliant collaboration, ...
Breaking Medicine News(10 mins):Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2
... DALLAS June 9, 2011 A gene linked to ... unrelated to cigarette smoking, UT Southwestern Medical Center research indicates. ... both diseases. In the study, mice bred to ... developed emphysema, and by gender also developed lung cancer at ...
... 8 (HealthDay News) -- New findings on the link between ... differences play an important role in the connection. ... common among women. However, the new study found that men ... migraines to also have PTSD. In addition, the investigators ...
... (HealthDay News) -- Dieters are more likely than non-dieters to ... For example, dieters rated food items with names such as ... as "pasta," while non-dieters made no such distinctions. Dieters ... the same candy when it was labeled "candy chew," and ...
... may involve injury to neurons, or nerve cells, in a ... to the authors of a new animal study. The results ... Meeting in Boston. "The possibility that brain injury may ... diet offers a new explanation for why sustained weight loss ...
... Researchers at Albert Einstein College of Medicine of ... of breast cancer. The findings, published today in the online ... helps cancer spread beyond the primary tumor. The research highlights ... author is Jeffrey Pollard, Ph.D. , professor of ...
... at the Institut de recherches cliniques de Montral (IRCM), and ... key molecule of the vascular system directs axons during the ... and the vascular system could be a good starting point ... will be published tomorrow by Neuron , a scientific ...
Cached Medicine News:Health News:UT Southwestern research uncovers genetic link between emphysema, lung cancer 2Health News:Migraine Plus PTSD 4 Times More Likely in Men: Study 2Health News:Eating a high-fat diet may rapidly injure brain cells that control body weight 2Health News:Einstein scientists find crucial molecule involved in spread of breast cancer 2Health News:Einstein scientists find crucial molecule involved in spread of breast cancer 3Health News:Connection discovered between the nervous system and the vascular system 2
(Date:10/22/2014)... Investor-Edge has initiated coverage on ... FOLD ), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ... Idera Pharmaceuticals Inc. (NASDAQ: IDRA ), and ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,419.48, up 2.40%, the Dow Jones ...
(Date:10/22/2014)... RIDGE, N.J. , Oct. 22, 2014 /PRNewswire/ ... (RMANJ), a world-renowned leader in the field of ... rapid approach to embryonic screening. The research abstract, ... Society for Reproductive Medicine (ASRM) meeting in ... screening (CCS) and single gene defect (SGD) pre-implantation ...
(Date:10/22/2014)... , Oct. 22, 2014 AVACEN Medical announced ... received 510 (k) OTC clearance by the U.S. Food ... to be marketed over the Internet for: the ... spasms; and minor strains and sprains . ... AVACEN 100 (MSRP $2495) is a sophisticated medical device ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... , PALM CITY, Fla., Dec, 17 Connectyx Technologies ... it has formed a distribution partnership with United States ... Supplies, Respiratory Supplies and Medications as well as Bladder ... Terms of the partnership were not disclosed, however Connectyx ...
... 17 Instacare Corp. (OTC Bulletin Board: ISCR) a ... and diagnostics and at home testing products for the ... e-health technologies and revolutionary cell phone centric technologies and ... of its Fiscal 2010 guidance, the Board has determined ...
Cached Medicine Technology:Connectyx Announces Distribution Partnership with United States Medical Supply 2Connectyx Announces Distribution Partnership with United States Medical Supply 3Instacare Corp. Board of Directors Sets Growth Plans for 2010 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: