Navigation Links
When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs
Date:5/23/2013

ted by phosphorylated AGO2, including miR-31, miR-192 and miR-193a-5p, also shared a long-loop structure in their precursors that miRNAs unaffected by AGO2 phosphorylation lack.

Hypoxic environments around tumors promote metastasis by helping cells evade programmed cell death. Hung and colleagues showed that EGFR-mediated AGO2 phosphorylation blocks cell death and enhances invasiveness under hypoxia.

Experiments in a mouse model of breast cancer confirmed that expression of EGFR and the presence of phosphorylated AGO2 increase during tumor progression under oxygen-starved conditions.

EGFR-AGO2 connection found in human breast tumors; reduces survival

The hypoxia-EGFR-AGO2 connection was strong in tumor samples from 128 breast cancer patients, but it was low or absent in normal breast tissue. In 125 breast cancer cases analyzed by the team, half of 62 patients with high levels of phosphorylated AGO2 survived to 48 months and beyond. Median survival had not been reached for the 63 patients in the low-level group, but 78 percent had survived to 48 months.

"One can imagine other receptors for platelet-derived growth factor and insulin-like growth factor also regulating miRNAs, perhaps by regulating Dicer or TBRP," Hung said. "This is a turning-point paper; it will induce lots of new questions for scientists to pursue."


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Low oxygen levels could drive cancer growth
2. Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
3. Should oxygen be used for patients with chronic heart failure?
4. Cooling Helps Oxygen-Deprived Newborns: Study
5. New anti-inflammatory drugs pinch off reactive oxygen species at the source
6. Lack of oxygen in cancer cells leads to growth and metastasis
7. COPD patients experience poorer sleep quality and lower blood oxygen levels
8. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
9. Study finds association between oxygen deprivation before birth and ADHD
10. Oxygen Deprivation in the Womb May Raise ADHD Risk
11. Oxygen Treatment May Improve the Odds for Extreme Preemies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 2014 Névo takes a bold step ... and adding advanced activity tracking and phone notifications for ... distance, calories burned, and more. , http://www.nevowatch.com ... healthy habits in their busy lives to look and ... that produce healthy results, but until now, style played ...
(Date:9/23/2014)... Many people have very limited knowledge and faulty ... television acts in which a hypnotist induces a trance-like state ... power of suggestion to have them do his bidding, often ... as an aid in managing bad habits like smoking and ... ways hypnotism can be used. “Hypnosis can facilitate treatment for ...
(Date:9/23/2014)... Texas (PRWEB) September 23, 2014 Medicine in ... its central Austin location at 711 W. 38th, Suite G4. ... at their north Austin location, increased demand for MIM’s superior ... “My team and I are extremely excited about bringing our ... Martha Pyron, owner of Medicine in Motion. “We’ll continue to ...
(Date:9/23/2014)... Recently, BuyTopDress.com, a popular supplier of wedding dresses and ... of fashionable marine ball dresses . Along with this, ... these brand new items; all of them are now provided ... to now, BuyTopDress.com has won more than 2000 happy customers ... with its products and after-sale services. The company is offering ...
(Date:9/22/2014)... 23, 2014 The Gesundheit! Institute ... new design and restructuring for their existing website. The Institute ... They needed a way to navigate to the different branches ... as present the look and feel of the site in ... 1971, when Patch Adams graduated from The Medical School of ...
Breaking Medicine News(10 mins):Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 3Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 2Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 3Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 4Health News:Austin Sports Medicine Practice to Host Grand Opening Event for Second Location 2Health News:Fashionable Marine Ball Dresses Added To BuyTopDress.com’s Collection 2Health News:Idea Marketing Group Launches a New Website for The Gesundheit! Institute 2Health News:Idea Marketing Group Launches a New Website for The Gesundheit! Institute 3
... do need supplements aren,t getting them, study shows , , ... U.S. children and teenagers may be popping vitamins and ... experts note that vitamin and mineral supplements are not ... , On the other hand, children who actually need ...
... Alberta organic chemist has been named the 2008 winner ... carried out in Canada. The prize is one of ... of disciplines including mathematics, engineering, chemistry, physics, and biology. ... on applications of compounds known as boronic acids and ...
... Focus on Auto Safety AdvocacyWASHINGTON, Feb. 2 Allstate ... and Auto Safety (Advocates) announced today the formation of ... The program aims to develop public policy fellows ... interest in highway and auto safety. "Advocates has ...
... is also useful when trying to spot fatigue , , MONDAY, Feb. ... Focus on the area around your eyes, a new study suggests, ... level of fatigue. , When asked to estimate the age ... the eye region almost half the time, researchers found. The number ...
... Seniors: "The Best Things in Life are FREE!",including an eye exam ... ... San Francisco, CA -- This February, EyeCare America is reminding seniors ... you can,t put a price tag on love, friendship or the ...
... the laboratory of Michael Karin, PhD, at the University ... first researcher to demonstrate a molecular link between inflammation ... the prevention and treatment of colitis-associated cancer (CAC), the ... Distinguished Professor of Pharmacology and Pathology and member of ...
Cached Medicine News:Health News:Many Kids Don't Need the Vitamins They're Taking 2Health News:Many Kids Don't Need the Vitamins They're Taking 3Health News:University of Alberta organic chemist receives top young Canadian scientist prize 2Health News:Allstate and Advocates for Highway and Auto Safety Unveil Public Policy Fellowship Program 2Health News:Allstate and Advocates for Highway and Auto Safety Unveil Public Policy Fellowship Program 3Health News:When Gauging Age, the Eyes Have It 2Health News:During February's Valentine's Promotion EyeCare America Offers No-Cost Medical Eye Care to Qualified Seniors 2Health News:During February's Valentine's Promotion EyeCare America Offers No-Cost Medical Eye Care to Qualified Seniors 3Health News:2 immune-system proteins linked to colitis-associated cancer 2
(Date:9/22/2014)... Spanien, September 23, 2014 ... sich Fernzugriffe auf eTMF im Jahr 2015 ... den Sponsoren von klinischen Versuchsreihen, die zunehmenden ... Vollständigkeit von Stammdateien mit Informationen über ihre ... erfüllen     Die bisher größte ...
(Date:9/22/2014)... 2014 Avanir Pharmaceuticals, Inc. (NASDAQ: ... sell $200 million of its common stock in an ... BofA Merrill Lynch are acting as joint book-running managers ... 30-day option to purchase additional shares of its common ... the offering are being sold by Avanir.  The offering ...
(Date:9/22/2014)... DUBLIN , Sept. 22, 2014 ... "The Market for Neurotechnology: 2014-2018" report to ... research report is the most comprehensive and up-to-date publication ... in-depth look at the technology, markets, competitors, and growth ... in the years 2014 through 2018. It forecasts the ...
Breaking Medicine Technology:Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 2Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 3Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 4Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 5Avanir Pharmaceuticals Announces Proposed Public Offering of Common Stock 2Avanir Pharmaceuticals Announces Proposed Public Offering of Common Stock 3The Market for Neurotechnology: 2014-2018 2
... Evidence Report Compares Effectiveness of CT Colonography to ... The value of CT colonography, also called virtual ... coverage of these procedures as a diagnostic method ... findings from meta-analyses performed by ECRI Institute suggest ...
... March 12 The following is being issued by Coast ... March 10, 2009, Coast IRB informed the public that it ... submitted to that Independent review board for evaluation. Coast ... commenced as part of a congressional "sting" operation. Apparently ...
Cached Medicine Technology:Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed 2Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed 3Congressional 'Sting' Operation Uncovered By Coast IRB 2
... technique independent blood films. The modern ... compact, quiet, easy to use slide ... distributed cell monolayers for WBC differential ... of slides and slide holders the ...
... 2000; a unique closed system for performing ... ,The CenSlide 2000 system is microprocessor controlled ... preset speed for one minute. At the ... is distributed evenly across the viewing area ...
Used for drainage and retrograde pyelogram in pediatric patients. A stiffening stylet is included to aid in catheter placement. Supplied sterile in peel-open packages. Intended for one-time use....
Used for stenting the urethra during hypospadias or epispadias repair and to allow post-operative drainage of the bladder. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: