Navigation Links
When memory-related region of brain is damaged, other areas compensate, study finds
Date:8/2/2010

Many neuroscientists believe the loss of the brain region known as the amygdala would result in the brain's inability to form new memories with emotional content. New UCLA research indicates this is not so and suggests that when one brain region is damaged, other regions can compensate.

The research appears this week in the early online edition of the journal Proceedings of the National Academy of Sciences (PNAS).

"Our findings show that when the amygdala is not available, another brain region called the bed nuclei can compensate for the loss of the amygdala," said the study's senior author, Michael Fanselow, a UCLA professor of psychology and a member of the UCLA Brain Research Institute.

"The bed nuclei are much slower at learning, and form memories only when the amygdala is not learning," he said. "However, when you do not have an amygdala, if you have an emotional experience, it is like neural plasticity (the memory-forming ability of brain cells) and the bed nuclei spring into action. Normally, it is as if the amygdala says, 'I'm doing my job, so you shouldn't learn.' With the amygdala gone, the bed nuclei do not receive that signal and are freed to learn."

The amygdala is believed to be critical for learning about and storing the emotional aspects of experience, Fanselow said, and it also serves as an alarm to activate a cascade of biological systems to protect the body in times of danger. The bed nuclei are a set of forebrain gray matter surrounding the stria terminalis; neurons here receive information from the prefrontal cortex and hippocampus and communicate with several lower brain regions that control stress responses and defensive behaviors.

"Our results suggest some optimism that when a particular brain region that is thought to be essential for a function is lost, other brain regions suddenly are freed to take on the task," Fanselow said. "If we can find ways of promoting this compensation, then we may be in a better position to help patients who have lost memory function due to brain damage, such as those who have had a stroke or have Alzheimer's disease.

"Perhaps this research can eventually lead to new drugs and teaching regimens that facilitate plasticity in the regions that have the potential to compensate for the damaged areas," he said.

While the current study shows this relationship for emotional learning, additional research in Fanselow's laboratory is beginning to suggest this is a general property of memory.


'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Aging and longevity tied to specific brain region in mice
2. Regional variation in health-care spending and utilization higher in Medicare than private sector
3. Medicine quality in Philippines and region strengthened with Philippine FDAs accreditation
4. Jacquelyn Clark Founder of N2Y, Inc. Wins Regional 2010 Ernst & Young Entrepreneur Of The Year Award for Northeast Ohio
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Dubai Podiatry Centre Becomes the Gulf Region's First Clinic to Bring Apple iPads to the Healthcare Field
7. Regional differences in C-section rate not a result of maternal request: UBC study
8. Houston Northwest Medical Center Becomes First Hospital in the Southwest Region Designated a Community of Respect™ Partner
9. Joseph Cosgrove Named as E&Y Entrepreneur Of The Year Finalist in the Greater Philadelphia Region
10. Unstable chromosome regions are the origin of yeasts brewing capacity
11. NIH study confirms location of stem cells near cartilage-rich regions in bones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... , ... “The Trainer”: an electrifying and suspenseful gunslinger novel with a ... an active imagination and an enthusiasm for action and adventure stories. , ... Hart, who sat looking at the thirty-three notches that lined the edges of the ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, an online plastic ... its companion print magazine. The new magazine, scheduled for release in mid-April, includes ... by board-certified doctors from across the country. , According to the senior editor ...
(Date:3/22/2017)... ... 22, 2017 , ... The American Society for Preventive ... form for prescribers to improve patients’ access to the revolutionary therapy for appropriate ... part of the article entitled “PCSK9 Inhibitor Access Barriers: Issues and Recommendations: ...
(Date:3/22/2017)... ... March 22, 2017 , ... In recognition of Colon Cancer ... focused on cancer patients, cancer centers and advocacy groups, and MJH Studios™, a ... series, “No Ifs, Ands, or Butts,” that focuses on Colorectal Cancer detection, prevention ...
(Date:3/22/2017)... ... March 22, 2017 , ... An intensive search of the medical ... reports Leslie Norins, MD, PhD. He says investigating this possibility, is important ... virus and in new infections with HIV. , His findings appear on ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... 2017 Serve You Rx Vermont, LLC, a wholly ... You), based in Milwaukee, Wisconsin , has ... in Middlebury, Vermont , from Pharmacy Health ... so it was perfect timing for this opportunity to present ... Serve You. "Like us, NEMOP has a high-touch service model, ...
(Date:3/22/2017)... , Mar 22, 2017 Research ... Immune Check Point Inhibitors Market & Clinical Pipeline Insight 2022" ... ... Inhibitors Market & Clinical Pipeline Insight 2022 report gives comprehensive ... and integration of immune check point inhibitors as main streamline ...
(Date:3/22/2017)... , March 22, 2017 ... Manufacturing Organization (CDMO), held a special event to introduce ... in Lexington, Kentucky . The inaugural ... Piramal Group Chairman Ajay Piramal, and Piramal Pharma ... ...
Breaking Medicine Technology: