Navigation Links
When injured muscles mistakenly grow bones
Date:7/20/2011

CHICAGO --- For hundreds of thousands of people, injuring a muscle through an accident like falling off a bike or having surgery can result in a strange and serious complication. Their muscles start growing bones.

No one understood what caused the abnormal bone growth, so there was no treatment. But now, research from Northwestern University Feinberg School of Medicine and the Perelman School of Medicine at the University of Pennsylvania shows that a neuropeptide in the brain called Substance P appears to trigger the formation of the extraskeletal bone. Eliminating Substance P prevents the bone growth.

The discovery - in human and animal tissues -- offers a molecular target for drugs to potentially prevent and treat the abnormal bone growth, which is called heterotopic ossification.

"Patients who have it become very uncomfortable, and there is no way to make it go away," said Jack Kessler, M.D., chair of neurology at Northwestern's Feinberg School, a neurologist at Northwestern Memorial Hospital and the senior author of the paper, which was published in the Journal of Cellular Biochemistry. "This explains why it happens and gives us a way to develop a therapy to potentially treat it."

Lixin Kan, research associate professor at Feinberg and lead author of the paper, found that Substance P is dramatically increased in newly damaged tissue of patients who have the more common heterotopic ossification as well as a rarer and debilitating genetic disease. In the genetic disease, connective tissue begins to ossify and turn into bone. It's called fibrodysplasia ossificans progressiva (FOP).

In the paper, Kan reports that knocking out Substance P in animals prevented the development of the extraskeletal bone in an animal model.

"This work establishes a common mechanism underlying lesion induction for nearly all forms of heterotopic ossification including brain and spinal cord injury, peripheral nerve injury, athletic injury, total hip replacement and FOP," said paper co-author Frederick Kaplan, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at Penn's Perelman School. "These novel findings usher in a new era in understanding of these complex disorders."


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. How to help heal an injured joint
2. Severely injured should go directly to trauma center: Research
3. 1 in 10 Child Athletes Injured, Experts Say
4. More Than 70,000 Kids Injured By Medical Devices Each Year
5. Law Firm Dussault and Zatir Settles Workers' Compensation Claim Concerning a Forty-Four-Year-Old Injured on the Job
6. Law Firm Dussault and Zatir Settles Lawsuit Involving Nurse Injured in a Motor Vehicle Accident
7. In brain-injured children, early gesturing predicts language delays
8. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
9. Charlotte Attorney Secures $1.4 Million Settlement for Cyclist Injured in Head-On Collision with Automobile
10. AAJ to Lawmakers: Remember Injured Patients
11. East Tennessee Attorney Brack Terry Obtains $120,000 Jury Award For Injured Mail Carrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: