Navigation Links
When injured muscles mistakenly grow bones
Date:7/20/2011

CHICAGO --- For hundreds of thousands of people, injuring a muscle through an accident like falling off a bike or having surgery can result in a strange and serious complication. Their muscles start growing bones.

No one understood what caused the abnormal bone growth, so there was no treatment. But now, research from Northwestern University Feinberg School of Medicine and the Perelman School of Medicine at the University of Pennsylvania shows that a neuropeptide in the brain called Substance P appears to trigger the formation of the extraskeletal bone. Eliminating Substance P prevents the bone growth.

The discovery - in human and animal tissues -- offers a molecular target for drugs to potentially prevent and treat the abnormal bone growth, which is called heterotopic ossification.

"Patients who have it become very uncomfortable, and there is no way to make it go away," said Jack Kessler, M.D., chair of neurology at Northwestern's Feinberg School, a neurologist at Northwestern Memorial Hospital and the senior author of the paper, which was published in the Journal of Cellular Biochemistry. "This explains why it happens and gives us a way to develop a therapy to potentially treat it."

Lixin Kan, research associate professor at Feinberg and lead author of the paper, found that Substance P is dramatically increased in newly damaged tissue of patients who have the more common heterotopic ossification as well as a rarer and debilitating genetic disease. In the genetic disease, connective tissue begins to ossify and turn into bone. It's called fibrodysplasia ossificans progressiva (FOP).

In the paper, Kan reports that knocking out Substance P in animals prevented the development of the extraskeletal bone in an animal model.

"This work establishes a common mechanism underlying lesion induction for nearly all forms of heterotopic ossification including brain and spinal cord injury, peripheral nerve injury, athletic injury, total hip replacement and FOP," said paper co-author Frederick Kaplan, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at Penn's Perelman School. "These novel findings usher in a new era in understanding of these complex disorders."


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. How to help heal an injured joint
2. Severely injured should go directly to trauma center: Research
3. 1 in 10 Child Athletes Injured, Experts Say
4. More Than 70,000 Kids Injured By Medical Devices Each Year
5. Law Firm Dussault and Zatir Settles Workers' Compensation Claim Concerning a Forty-Four-Year-Old Injured on the Job
6. Law Firm Dussault and Zatir Settles Lawsuit Involving Nurse Injured in a Motor Vehicle Accident
7. In brain-injured children, early gesturing predicts language delays
8. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
9. Charlotte Attorney Secures $1.4 Million Settlement for Cyclist Injured in Head-On Collision with Automobile
10. AAJ to Lawmakers: Remember Injured Patients
11. East Tennessee Attorney Brack Terry Obtains $120,000 Jury Award For Injured Mail Carrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... MedaCheck, a leading medication ... outcomes, has announced its partnership with GrandView Health Services. , With decades of ... counter and prescription drug pharmacy services to thousands of residents. Serving Indiana, Ohio, ...
(Date:5/2/2016)... TN (PRWEB) , ... May 02, 2016 , ... ... and behavioral health services, today announced the opening of Twin Lakes Recovery Center. ... will be Summit’s first in the state. The residential facility is set ...
(Date:5/1/2016)... (PRWEB) , ... May 01, 2016 , ... Women's Excellence ... Essential Oils and taught by Patti Dolan, a Young Living Gold Member. , The ... 6:30pm - 7:15pm followed by a small intro to the Oils that can benefit ...
(Date:4/30/2016)... (PRWEB) , ... May 01, 2016 , ... Serenity Recovery, ... to rehabilitation, has produced a new video that focuses on one of the more ... recent sessions and clips from interviews with a participating patients and the Yoga class ...
(Date:4/30/2016)... , ... April 30, 2016 , ... ... Boise, President and CEO of EMED, today signed a multifaceted agreement which will ... and the Northern Caribbean University Department of Natural and Applied Sciences, Allied Health ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016  Marking its one year ... and ovarian cancer risk test, Color Genomics ... genes that highly impact the most common hereditary ... the Color Test analyzes hereditary cancer risks for ... uterine cancers. The Color Test is physician ordered ...
(Date:4/28/2016)... YORK , April 28, 2016 ... online consumer insights on healthcare, announced today that it ... their report Cool Vendor in Life Sciences, 2016, ... April 15, 2016.  The report focuses on life-science- oriented ... gain insight from patients and doctors, confirm medication ingestion, ...
(Date:4/28/2016)... April 28, 2016 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug delivery ... upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... New York . Nadav Kidron , ... conference. Presentation Details:   PIONEERS ...
Breaking Medicine Technology: