Navigation Links
When injured muscles mistakenly grow bones
Date:7/20/2011

CHICAGO --- For hundreds of thousands of people, injuring a muscle through an accident like falling off a bike or having surgery can result in a strange and serious complication. Their muscles start growing bones.

No one understood what caused the abnormal bone growth, so there was no treatment. But now, research from Northwestern University Feinberg School of Medicine and the Perelman School of Medicine at the University of Pennsylvania shows that a neuropeptide in the brain called Substance P appears to trigger the formation of the extraskeletal bone. Eliminating Substance P prevents the bone growth.

The discovery - in human and animal tissues -- offers a molecular target for drugs to potentially prevent and treat the abnormal bone growth, which is called heterotopic ossification.

"Patients who have it become very uncomfortable, and there is no way to make it go away," said Jack Kessler, M.D., chair of neurology at Northwestern's Feinberg School, a neurologist at Northwestern Memorial Hospital and the senior author of the paper, which was published in the Journal of Cellular Biochemistry. "This explains why it happens and gives us a way to develop a therapy to potentially treat it."

Lixin Kan, research associate professor at Feinberg and lead author of the paper, found that Substance P is dramatically increased in newly damaged tissue of patients who have the more common heterotopic ossification as well as a rarer and debilitating genetic disease. In the genetic disease, connective tissue begins to ossify and turn into bone. It's called fibrodysplasia ossificans progressiva (FOP).

In the paper, Kan reports that knocking out Substance P in animals prevented the development of the extraskeletal bone in an animal model.

"This work establishes a common mechanism underlying lesion induction for nearly all forms of heterotopic ossification including brain and spinal cord injury, peripheral nerve injury, athletic injury, total hip replacement and FOP," said paper co-author Frederick Kaplan, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at Penn's Perelman School. "These novel findings usher in a new era in understanding of these complex disorders."


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. How to help heal an injured joint
2. Severely injured should go directly to trauma center: Research
3. 1 in 10 Child Athletes Injured, Experts Say
4. More Than 70,000 Kids Injured By Medical Devices Each Year
5. Law Firm Dussault and Zatir Settles Workers' Compensation Claim Concerning a Forty-Four-Year-Old Injured on the Job
6. Law Firm Dussault and Zatir Settles Lawsuit Involving Nurse Injured in a Motor Vehicle Accident
7. In brain-injured children, early gesturing predicts language delays
8. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
9. Charlotte Attorney Secures $1.4 Million Settlement for Cyclist Injured in Head-On Collision with Automobile
10. AAJ to Lawmakers: Remember Injured Patients
11. East Tennessee Attorney Brack Terry Obtains $120,000 Jury Award For Injured Mail Carrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
Breaking Medicine Technology: