Navigation Links
When cancer runs in the family
Date:5/27/2011

5% to 10% of all breast cancers are monogenic in origin. In other words, there is a mutation of the genes BRCA1, BRCA2 or other high-risk genes. In this edition of Deutsches rzteblatt International (Dtsch Arztebl Int 2011; 108(19): 323 30), Alfons Meindl of the Klinikum rechts der Isar (Munich) and coauthors report on new insights into the pathogenesis and treatment of hereditary breast and ovarian cancer and newly-discovered risk genes.

Meindl et al. evaluated data including those derived from the work of the German Consortium for Hereditary Breast and Ovarian Cancer. It was shown that if BRCA1 or BRCA2 is mutated, there is a breast cancer risk of up to 85% and an ovarian cancer risk of up to 50%. Another predisposing gene for breast and ovarian cancer is RAD51C. Like BRCA1 and BRCA2, it plays a central role in DNA repair and is mutated in approximately 1.5% to 4% of all families predisposed towards breast and ovarian cancer.

When there is evidence of a high-risk gene mutation, the authors recommend intensive risk-adjusted screening. Risk can be reduced by prophylactic bilateral removal of the breasts and ovaries. In the future, drug-based approaches to risk reduction may also be possible.

In Germany, breast cancer is the most common malignant disease in women and ovarian cancer the gynecological tumor with the highest mortality rate. There may be a hereditary cancer burden even if only two or more women, or one young woman, in a family develop the disease. http://www.aerzteblatt.de/v4/archiv/pdf.asp?id=89366


'/>"/>

Contact: Prof. Dr. Alfons Meindl
alfons.meindl@lrz.tum.de
Deutsches Aerzteblatt International
Source:Eurekalert

Page: 1

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 29, 2014) Using quality improvement measures in eight ... Cardiovascular Disease Study Group, researchers have found a way ... with contrast dye. , Currently, 7-15 percent of these ... end up with kidney injury, which can result in ... temporary or permanent dialysis, says a study published in ...
(Date:7/29/2014)... New York (PRWEB) July 29, 2014 ... behalf of individuals who allegedly suffered serious liver ... continue to move forward in a multidistrict litigation ... Pennsylvania, Bernstein Liebhard LLP reports. According to an ... certain deadlines pertaining to bellwether case and ...
(Date:7/29/2014)... By Alan Mozes ... -- Treating certain adult autism patients with just a single ... judge facial expressions and emotions, Japanese researchers report. Known ... a role in emotional bonding between lovers, and between mothers ... neural activity in a key area of the brain that ...
(Date:7/29/2014)... The Law Offices of Michael Cordova is proud ... non-profit organization providing grief camps for kids, teens, adults, and ... our clients experience from the death of a loved one. ... like Stepping Stones of Hope, as they provide hope and ... Hope also includes a monthly support group and a variety ...
(Date:7/29/2014)... receive steady follow-up care, the living donors themselves ... care more accessible, UC San Francisco and Walgreens ... the first program in the country that provides ... kidney donors. , UCSF will provide vouchers for ... Walgreens pharmacies and Healthcare Clinic at select Walgreens ...
Breaking Medicine News(10 mins):Health News:Reducing kidney injury using a quality improvement method 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:'Love Hormone' Oxytocin May Help Some With Autism 2Health News:'Love Hormone' Oxytocin May Help Some With Autism 3Health News:The Law Offices of Michael Cordova is Sponsoring Stepping Stones of Hope, a Non-Profit Organization Providing Grief Camps for Kids, Teens, Adults, and Families 2Health News:Caring for donors 2Health News:Caring for donors 3
... unstoppable, WHO director says; U.S. health officials caution that ... widespread , THURSDAY, June 11 (HealthDay News) -- ... flu pandemic since 1968, triggered by the rapid spread ... America, Europe and regions beyond. , WHO director Dr. ...
... NeuroScience, Inc. has launched an antioxidant protocol that combines ... antioxidant compounds, including OSR#1, CysNAC, and NeuroVitamins. These products ... fat soluble and water soluble areas of the body. ... body,s supply of antioxidants, mainly glutathione, is insufficient to ...
... The National Medical Association (NMA) stands firm in its ... Obama. "AMA,s reservations are duly noted, however, competition is healthy, ... to create the competition that will lead to lower cost ... Barley Britton, president of the National Medical Association. "Public plans ...
... Calif., June 11 As a result of the ... or eliminating bonus payouts in addition to extending cost ... pay trends surveys by Aon Consulting,s Radford, a leading ... sciences industries. , , (Logo: ...
... in the June issue of the Journal of the ... by air traffic controllers tracks patient data more effectively and ... use of clipboards. Currently there is no standard practice ... the radiology suite, operating rooms, the intensive care unit, inpatient ...
... insulin resistance, study finds , THURSDAY, June 11 (HealthDay ... insulin resistance and lead to a condition known as ... outlined Thursday at the Endocrine Society,s annual meeting in ... risk for diabetes. The same team of researchers was ...
Cached Medicine News:Health News:Swine Flu Now a Pandemic 2Health News:Swine Flu Now a Pandemic 3Health News:Swine Flu Now a Pandemic 4Health News:Swine Flu Now a Pandemic 5Health News:Swine Flu Now a Pandemic 6Health News:Swine Flu Now a Pandemic 7Health News:Swine Flu Now a Pandemic 8Health News:Swine Flu Now a Pandemic 9Health News:Swine Flu Now a Pandemic 10Health News:Swine Flu Now a Pandemic 11Health News:Swine Flu Now a Pandemic 12Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 2Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 3Health News:Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford 4Health News:Study finds air traffic control tracking method reduces errors in trauma management 2Health News:Nicotine May Help Spur 'Prediabetes' 2
(Date:7/29/2014)... YORK , July 29, 2014  Longtime industry ... Caremark Rx, Drew Crawford today announced the ... the leading independent media source dedicated to delivering fair, ... on the pharmacy benefit management (PBM) industry .  ... of, and context behind, industry news.   The outlet will ...
(Date:7/29/2014)... , July 29, 2014 McGraw-Hill Education Professional, ... the science, technical, and medical communities, has announced the ... off-line mobile application of the world-renowned medical education platform. ... AccessMedicine App , available for download onto all ... be able to gain access to valuable AccessMedicine ...
(Date:7/29/2014)... According to a new market ... Devices Market - Global Forecast, Market Share, Size, Growth ... trauma fixation devices market is estimated at USD 6.1 ... a CAGR of 7.2% from 2014 to 2019, to ... 2020. Browse the Orthopedic Trauma Fixation Devices ...
Breaking Medicine Technology:Drew Crawford Announces Launch of PBM365 Media 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4
... This programmable system automates the denaturation ... procedures, and provides walk-away convenience for ... cost unit accepts a wide range ... use, and reduces hands-on time by ...
... DiffSpin Slide Spinner for technique independent ... wedge smears.,DiffSpin is a compact, quiet, ... the preparation of uniformly distributed cell ... with a start-up supply of slides ...
... systems deliver pulsed light over one smooth ... spikes (which may damage skin) that other ... sends a chilled water supply through the ... which is cooled to as low as ...
... small, quiet, high-speed centrifuge. It employs a ... results in nearly vibration- free operation. Light ... speed and full breaking in a few ... a simple push-on/ pull-off; transforming the centrifuge ...
Medicine Products: