Navigation Links
When It Comes to Memory, It's All About Location

Proteasomes that control protein levels could key future treatments for Alzheimer's

FRIDAY, April 25 (HealthDay News) -- A new report finds that where protein-destroying machines reside in the brain's nerve cells may help determine how memories are formed, a finding that may play a role in future treatments for Alzheimer's and other brain diseases.

Wake Forest University School of Medicine researchers studying mice discovered that cylinder-shaped proteasomes, which help control protein levels, play different roles in controlling synapse strength depending on where they are in the nerve cells of the hippocampus, an area of the brain linked to memory.

When humans or animals learn and store information in their memory, these connections between cells become stronger or weaker, Ashok Hegde, associate professor of neurolobiology and anatomy at Wake Forest, said in a prepared statement. For example, if people learn to do something better, such as playing softball, the synapses that control hand-eye coordination will become stronger. If they learn to ignore something, such as the barking of a neighbor's dog, then the synapses that control paying attention will become weaker.

The findings were published in the current issue of Learning & Memory.

It is known that the degradation of proteins, which are made by cells to control cell functions, plays an important role in memory function. The team found that proteasomes in the dendrites -- the branched parts of a neuron that conduct electrical stimulation -- limit the connection strength between cells. Proteasomes in the nucleus, which contains the cell's genetic material, help maintain synapse strength for long periods of time.

The researchers are now trying to learn how to block proteasome activity specifically in the dendrites of mice to increase the strength of synapses and of memory. In their ongoing studies, the mice will be analyzed on how well they can learn to navigate a maze.

"If we see a memory enhancement when we block the proteasome in dendrites, we can use this strategy to treat memory loss," Hegde said.

More information

The Alzheimer's Association has more about current treatments for Alzheimer's disease.

-- Kevin McKeever

SOURCE: Wake Forest University Baptist Medical Center, news release, April 23, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. MRI finds breast cancer before it becomes dangerous
2. Comparison of obstetric outcomes between on-call and patients own obstetricians
3. Continued Statin Use Boosts Post-Stroke Outcomes
4. Video: Nutrition Comes to NASCAR
5. MinuteClinic Becomes Participating Provider with Assurant Health
6. QI projects may -- or may not -- improve patient safety and outcomes
7. Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey
8. Neusoft Becomes First Global Growth Company Partner of World Economic Forum
9. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
10. Womens World Banking Welcomes New Network Member From Tunisia
11. Bypass Off-Pump Boosts Womens Outcomes
Post Your Comments:
(Date:11/24/2015)... ... ... Willey , has answered a new calling – to relieve snoring and sleep apnea for ... and sleep apnea through oral appliance therapy. He is one of a number ... of four in the Illinois area. , Dr. Willey’s location is at 11825 ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Kevin Day, local ... help the community stress less this holiday season. During the Indiana winter months, ... people's lives and the team at AlignLife want to help provide the tools needed ...
(Date:11/24/2015)... OR (PRWEB) , ... November 24, 2015 , ... Dehydration, ... too much body water to perspiration in the hot sun, and heat stroke and ... Fresh water advocate and radio host Sharon Kleyne. Every cell, system and structure requires ...
(Date:11/24/2015)... ... , ... There’s nothing better than giving the gift of green this holiday ... , This year, gardens are popping up in the most unexpected places. A variety ... Gardens’ African Keyhole Garden Bed ($499) , Water conscious gardeners – and that should ...
(Date:11/24/2015)... ... November 24, 2015 , ... Tudore Tranquility is a new restaurant in Tokyo, ... plant-based fine dining menu that is full of flavorful and creative dishes that exceed ... wedding dinner or a small intimate event. The décor looks stunning with gold and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Abaxis, Inc. (NasdaqGS: ABAX ), a ... the medical, research, and veterinary markets worldwide, announced today ... present at the 27 th Annual Piper Jaffray ... a.m. ET. The conference will be held at The ... City . Abaxis, Inc. is a ...
(Date:11/24/2015)... Edelris announce today that they have ... Poxel, CNRS, UCBL and ENS-Lyon on a new treatment to ... Hepatitis B virus (HBV) infection is a major public ... worldwide, 20 to 40% of them being at risk of ... existence of an effective preventive vaccine, the HBV infection is ...
(Date:11/24/2015)... MONROVIA, Calif. , Nov. 24, 2015 ... company developing engineered monoclonal antibodies for the treatment of ... announced that Bassil Dahiyat , Ph.D., president and ... in December: , 2015 Piper Jaffray Healthcare ... ET Location: New York, NY ...
Breaking Medicine Technology: