Navigation Links
When It Comes to Memory, It's All About Location
Date:4/25/2008

Proteasomes that control protein levels could key future treatments for Alzheimer's

FRIDAY, April 25 (HealthDay News) -- A new report finds that where protein-destroying machines reside in the brain's nerve cells may help determine how memories are formed, a finding that may play a role in future treatments for Alzheimer's and other brain diseases.

Wake Forest University School of Medicine researchers studying mice discovered that cylinder-shaped proteasomes, which help control protein levels, play different roles in controlling synapse strength depending on where they are in the nerve cells of the hippocampus, an area of the brain linked to memory.

When humans or animals learn and store information in their memory, these connections between cells become stronger or weaker, Ashok Hegde, associate professor of neurolobiology and anatomy at Wake Forest, said in a prepared statement. For example, if people learn to do something better, such as playing softball, the synapses that control hand-eye coordination will become stronger. If they learn to ignore something, such as the barking of a neighbor's dog, then the synapses that control paying attention will become weaker.

The findings were published in the current issue of Learning & Memory.

It is known that the degradation of proteins, which are made by cells to control cell functions, plays an important role in memory function. The team found that proteasomes in the dendrites -- the branched parts of a neuron that conduct electrical stimulation -- limit the connection strength between cells. Proteasomes in the nucleus, which contains the cell's genetic material, help maintain synapse strength for long periods of time.

The researchers are now trying to learn how to block proteasome activity specifically in the dendrites of mice to increase the strength of synapses and of memory. In their ongoing studies, the mice will be analyzed on how well they can learn to navigate a maze.

"If we see a memory enhancement when we block the proteasome in dendrites, we can use this strategy to treat memory loss," Hegde said.

More information

The Alzheimer's Association has more about current treatments for Alzheimer's disease.



-- Kevin McKeever



SOURCE: Wake Forest University Baptist Medical Center, news release, April 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. MRI finds breast cancer before it becomes dangerous
2. Comparison of obstetric outcomes between on-call and patients own obstetricians
3. Continued Statin Use Boosts Post-Stroke Outcomes
4. Video: Nutrition Comes to NASCAR
5. MinuteClinic Becomes Participating Provider with Assurant Health
6. QI projects may -- or may not -- improve patient safety and outcomes
7. Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey
8. Neusoft Becomes First Global Growth Company Partner of World Economic Forum
9. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
10. Womens World Banking Welcomes New Network Member From Tunisia
11. Bypass Off-Pump Boosts Womens Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... 28, 2016 , ... May 26, 2016- In search of the K. Warriors, ... event of “K Warriors” on June 4, 2016 at Ashbury Hotel and Suites 600 ... sponsored and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), This ...
(Date:5/28/2016)... , ... May 28, 2016 , ... In a part of the city where’s it’s ... new farm-to-table Kelowna restaurants is hoping to attract diners with a taste for ... Suites officially opened the doors to Cornerstone Grill, an urban casual restaurant focusing on ...
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , designer ... timber frame barn kits, which can be found on its website at SouthlandLogHomes.com. , ... barn plans, and they highlight the craftsmanship of timber post and beam construction. ...
(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. ... today that it has been recognized as one of the best small businesses for ... named as one of nine small businesses providing progressive benefits to new parents on ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent ... the demand for a sustainable product to aid in the rehabilitation process has steadily ... the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics has now ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... SPRINGS, Florida , May 25, 2016 ... Business Conference & Expo earlier this month, the numbers ... As revenues continue to climb into the billions, more ... the newly released 4th Edition State of Legal Marijuana ... Frontier, a cannabis-focused data-analysis firm, much of the increase ...
(Date:5/25/2016)... , May 25, 2016 Digital Health ... to it by the US Patent and Trademark ... technology includes proprietary processes for electronic opt-­in and ... and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows for ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
Breaking Medicine Technology: