Navigation Links
What's been causing your knee to ache? Smurfs!
Date:10/18/2007

A new clinical trial seeks to predict who is most likely to experience osteoarthritis, and to test whether an experimental treatment can prevent it altogether. Physicians are setting their sights on people who sustain a knee injury, seeking to understand why nearly half of them will later go on to develop osteoarthritis, a debilitating condition that causes pain and disability in more than 20 million Americans each year.

The work is funded by a special class of National Institutes of Health grants awarded to research programs that show promise of quickly translating basic science discoveries into patient treatments. In this case, initial research has shown that an enzyme which controls the response of cells to growth factors may in fact be a major cause of osteoarthritis. The enzymes are called "Smad Ubiquitination Regulatory Factors, or, smurfs, but unlike the small, loveable blue cartoon characters, researchers believe that a particular form of these regulatory enzymes, smurf2, might in fact be responsible for Americas leading cause of disability.

We believe that smurf2 controls whether or not a cartilage cell matures and calcifies into hard bone, which is a very good thing when turned on in those areas of the body where we are supposed to have hard bone, said Randy Rosier, M.D., Ph.D., professor of Orthopaedics and director of Research Translation in Orthopaedics at the University of Rochester Medical Center. But when smurf2 is active in joint cartilage, it may set off a chain reaction that leads to the steady deterioration of the smooth gliding surface tissue, or cartilage, which comprises the joint surface. When this occurs, the cartilage breaks down and severely damages the weight-bearing surface of a joint. Or, put another way, activation of smurf2 in the joint cartilage appears to significantly contribute to the onset of osteoarthritis.

Frog Embryos and Cartilage Cells

Over the past decade, smurfs have begun
'/>"/>

Contact: Germaine Reinhardt
Germaine_Reinhardt@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Poor health care in Russia maybe causing Decline in its Population
2. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
3. Protein causing spread of colon cancer identified
4. Ulcer causing bug found in stored food
5. Colon cancer risk linked to genes causing Hemochromatosis
6. Head injury X-rays may actually be causing harm
7. Breathing Cancer Causing Compounds During Pregnancy Found To Affect Offspring
8. Cancer Causing Herpes Virus At Last May Have A Cure
9. Arthritis drugs are causing skin problems
10. Tetanus causing toxin has therapeutic properties
11. Reason for diabetes drug causing edema discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... The “Human Insulin Market by ... Premixed), Modern Human Insulin (Rapid Acting, Long Acting, ... Tresiba, Others) - Forecast to 2019” provides a ... current market trends,and strategies impacting the global human ... of the revenue and share analysis. , Browse ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 GBK, the luxury ... 2014 Emmy Award Nominees and Presenters at the annual GBK ... 22nd and 23rd in Beverly Hills from 11am – 6pm. ... and music by DJ Morgan Hildebrand. , As always, GBK ... will feature several charities at the lounge. GO Campaign is ...
(Date:8/20/2014)... VA (PRWEB) August 20, 2014 What ... by Getting Locked Out of the Market, **FDAnews Webinar**, ... EDT, http://www.fdanews.com/DoNowforUDI , Hospitals and other buyers ... due to ineffective product tracking systems. , Complying with ... is customer demands to implement UDI as soon as ...
(Date:8/19/2014)... The elegant bamboo floorings from BambooIndustry.com ... houses in an environmentally conscious way with the company’s ... and have an aluminum oxide finish to help resist ... high-traffic areas. , Recently, the company has released its ... . These fresh items are specially made for global ...
(Date:8/19/2014)... 2014 For decades it has been ... chiropractic adjustments are dangerous and cause strokes, cervical artery ... they do not recommend chiropractic to their patients. Now ... do refer to chiropractors because they have read the ... new research has popped up that tries to cast ...
Breaking Medicine News(10 mins):Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 2Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 3Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 4Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 3Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 4Health News:BambooIndustry.com Announces Up To 30% Discount On Its New Click Strand Woven Bamboo Floorings 2Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 2Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 3Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 4
... Penn Avenue Place buildings participate in World ... Wildlife Fund,s (WWF) Earth Hour, PITTSBURGH, ... Place and Penn Avenue Place facilities,will go dark from 8 to ... companies around the world in the World Wildlife Fund,s,(WWF) Earth Hour ...
... quick laugh and easy smile of a woman who continues ... She still works every day in the family business, heads ... for her energetic grandchildren. , This winter when the ... third time, her oncologist prescribed a new breed of targeted ...
... March 27 The Men,s Health Policy,Center, a ... Network,(MHN), announced today that they are hosting an ... Medicare and Medicaid Services (CMS) practice,that unfairly restricts ... "This petition allows people who are impacted by ...
... New Poll: Teens Still Feel Targeted By Tobacco Advertising ... 27 Kids across D.C. will,rally against tobacco on ... for the 13th annual Kick Butts Day, sponsored by ... across the nation,(for a list of local events, go ...
... The Richard B. and,Lynne V. Cheney Cardiovascular ... have joined the Institute,s Board of Directors. As ... Institute., "Mary Matalin,s experience in public affairs ... Institute as we build our organization and educate,communities ...
... March 27 Clarient, Inc.,(Nasdaq: CLRT ), a ... pharmaceutical industry, today announced,that it is scheduled to make ... Annual Las Vegas Investor Conference at 4:00 p.m. PDT ... is being held at the Palms,Casino Resort April 2-4, ...
Cached Medicine News:Health News:Highmark, Prominent Part of Pittsburgh City Skyline, to Go Dark for One Hour to Support the Environment 2Health News:Saving cancer patients' skin 2Health News:Saving cancer patients' skin 3Health News:Men's Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications 2Health News:D.C. Kids 'Kick Butts' on April 2 2Health News:D.C. Kids 'Kick Butts' on April 2 3Health News:Mary Matalin and John Ray Join the Cheney Cardiovascular Institute Board of Directors 2Health News:Clarient to Present at the B. Riley & Co. 9th Annual Las Vegas Investor Conference 2
(Date:8/19/2014)...  Sequence, Inc., an industry leader in the field of ... manufacturers is opening a third office location in the "Gateway ... a result of demand by clients to provide cost effective ... allows Sequence to better serve new and existing customers in ... office provides Sequence a hub to support customers ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets ... Global Strategic Business Report" report to their offering. ... Products in US$ Thousands by the following three major Application ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ...
(Date:8/18/2014)... NAGOYA, Japan , Aug. 19, 2014 ... ASAHI INTECC (Securities Code 7747, Second Section, ... plans to develop a new, differentiated fractional flow reserve ... device intended to improve handling compared to existing FFR ... field in interventional cardiology that exceeds $250 million worldwide ...
Breaking Medicine Technology:Quality and Compliance Solutions Provider Announces Opening of St. Louis, Missouri Office 2Global Anti-Adhesion Products - Strategic Business Report 2014 2Boston Scientific and ASAHI INTECC Announce Joint Development and Manufacturing Programs 2Boston Scientific and ASAHI INTECC Announce Joint Development and Manufacturing Programs 3Boston Scientific and ASAHI INTECC Announce Joint Development and Manufacturing Programs 4
... results of the Spare the,Nephron (STN) study, ... protocol using CellCept(R) (mycophenolate,mofetil), showed the CellCept-based ... with improved renal function when compared with ... (CNI)., Furthermore, the study showed this ...
... Clinical Phase 2 data presented at American Society of Clinical ... ... MEDX ) today announced updated long-term follow-up and overall,survival (OS) ... ipilimumab in combination with dacarbazine (DTIC) where 11.4%, or 4 of,35 ...
Cached Medicine Technology:Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function 2Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function 3Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function 4Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function 5Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 2Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 3Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 4
... The HSV Non-Typing ASR contains primers and ... a 92 bp region of the HSV Type ... requires an instrument that can detect a FAM ... The Cepheid Analyte Specific Reagent* (ASR) program is ...
... compact system is perfect for the office, ... cost effective microhematocrits are required. Featuring a ... offers a range of important benefits: - ... Meets NCCLS standards - Read tubes in ...
... Palomar systems deliver pulsed light over ... multiple power spikes (which may damage skin) ... Cooling technology sends a chilled water supply ... sapphire tip, which is cooled to as ...
Used to provide drainage of urine from the bladder. All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Inte...
Medicine Products: