Navigation Links
What wakes dormant tumor cells
Date:11/28/2011

Prostate tumor cells can be lulled to sleep by a factor released by bone cells, according to a study published online this week in the Journal of Experimental Medicine (www.jem.org). Disease recurs in up to half of prostate cancer patients after treatment, often as a result of metastases that spread to distant organs.

Kounosuke Watabe and colleagues at Southern Illinois University School of Medicine now show that BMP7, a protein pumped out by cells that line the bone interior, signals tumor cells to enter a state of hibernation. But this state is reversible. In mice, withdrawal of BMP7 acts like an alarm clock, restarting tumor growth.

Prostate cancer patients bearing tumors that express BMPR2BMP7's binding partnershow longer recurrence-free survival than those whose tumors lack BMPR2.

These findings suggest that therapies aimed at maintaining or mimicking BMP7 expression may help prevent prostate tumor recurrence.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers discover new way to kill pediatric brain tumors
2. Researchers create drug to keep tumor growth switched off
3. Fluorescent probes light up cancerous tumors
4. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
5. Drug for advanced kidney cancer shrinks tumors prior to surgery
6. Researchers discover second protective role for tumor-suppressor
7. Personalizing cancer: Creating biomarkers from tumor DNA
8. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
9. Tumor mechanism identified
10. Mayo oral cancer study shows full tumor genome
11. How estrogen feeds breast tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
Breaking Medicine Technology: