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What should be the goal of treatment in metastatic breast cancer?
Date:3/24/2010

l improvement in overall survival was four to six months, and 44% believed that a two to four month improvement in survival was meaningful.

Sixty percent of the oncologists surveyed believed that their patients also considered an improvement in overall survival to be the most important endpoint. The patients agreed, with 88% feeling that the primary goal of their treatment was to prolong life. However, when it came to the length of time of that survival, major differences with the doctors emerged, with 46% of patients thinking that only more than 12 months additional survival would make taking a treatment worthwhile for them; 17% thought that an extra 10-12 months would be acceptable, and only 10% thought that one to two months additional survival would be the minimal acceptable improvement.

Sixty-three percent of patients also believed that slowing tumour growth was a goal of treatment, and shrinking tumour burden and improving quality of life were also important to 62% of them; 17% thought shrinking tumour size was the most important goal of treatment. Fifty percent felt that improving symptoms and pain were other important therapeutic goals. Among the doctors, 36% believed that, after overall survival, overall quality of life would be the second most important factor to patients with metastatic breast cancer.

"This was only a small study and needs to be followed up on a larger scale," says Dr. Sheik-Yousouf. "However, the survey highlights major differences in the expectations of the outcome of treatment of metastatic breast cancer between oncologists and patients. We need not only to improve the way we discuss treatment options with patients, but also to ensure that clinical trials of new drugs are designed to meet the expectations of patients and doctors alike. We hope that by sharing the results of our study with our peers, industry, and government we may be able help them better develop new trials and guide their efforts in the ap
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Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

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