Navigation Links
What roles does TSP-1 play in liver fibrogenesis?
Date:5/20/2008

In rats with diethyl nitrosamine induced cirrhosis, TSP-1 expression has been found to correlate with the progression of fibrosis. Furthermore, TSP-1 expression was higher in rat livers with high vascular densityin other words, angiogenesis. This study, performed by a team led by Dr. Glsm zlem Elpek, is described in a research article to be published on April 14, 2008 in the World Journal of Gastroenterology.

Thrombospondin 1 (TSP-1) is involved in complex processes including wound healing and angiogenesis. In non-neoplastic diseases of the liver, although the association of TSP-1 with latent transforming growth factor - beta1 (TGF- beta1) has been demonstrated in a few studies, the relationship between TSP-1 and angiogenesis during liver fibrogenesis has not been documented.

TSP-1 expression strongly correlates with fibrogenesis and angiogenesis in experimental cirrhosis.

In the view of the authors, the results of this study suggest TSP-1 might contribute to the wound healing response to liver injury as an inducer of angiogenesis, and could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.

The fact chronic inflammatory liver diseases respond poorly to immunosuppressive and anti-inflammatory therapy shows angiogenesis might be a promising therapeutic target in the prevention of fibrosis. Recently, several antiangiogenic therapeutic strategies have been shown to suppress liver fibrosis development in experimental studies.

Using an experimental model, this research was performed by doctors from the Department of Pathology of the Faculty of Medicine at the University of Akdeniz, Antalya, Turkey.

Further research should explain the exact role of TSP-1 in hepatic angiogenesis, and whether this protein could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Best Practice Database: Complimentary Excerpt of Ensuring a Successful New Product Launch Through Effective Processes and Authority Roles
2. Is extra-corporal liver support with prometheus safe in patients with end-stage liver disease?
3. Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM)
4. Risk threshold of daily alcohol intake and drinking duration in liver injury?
5. Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
6. AmeriCares Delivers Life-Saving Aid to Myanmar
7. Supreme Master Ching Hai International Association Delivering US$160,000 in Aid to Earthquake Survivors in China
8. Suicide Prevention Group Delivers Much-Needed Message to Pennsylvanias Elderly
9. Mercy Corps Delivers Lifesaving Supplies to China Earthquake Survivors
10. Embryonic pathway delivers stem cell traits
11. Four Rivers Software Systems Delivers TMS Enterprise 2008.3.4
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative ... has initiated cultivation and processing operations at its production facility, and opened its ... Puradigm is the manufacturer of a complete system of proactive air and surface ...
(Date:6/24/2016)... ... , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event ... that have been wounded in battle and their families. Venture Construction Group is a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: