Navigation Links
What roles does TSP-1 play in liver fibrogenesis?
Date:5/20/2008

In rats with diethyl nitrosamine induced cirrhosis, TSP-1 expression has been found to correlate with the progression of fibrosis. Furthermore, TSP-1 expression was higher in rat livers with high vascular densityin other words, angiogenesis. This study, performed by a team led by Dr. Glsm zlem Elpek, is described in a research article to be published on April 14, 2008 in the World Journal of Gastroenterology.

Thrombospondin 1 (TSP-1) is involved in complex processes including wound healing and angiogenesis. In non-neoplastic diseases of the liver, although the association of TSP-1 with latent transforming growth factor - beta1 (TGF- beta1) has been demonstrated in a few studies, the relationship between TSP-1 and angiogenesis during liver fibrogenesis has not been documented.

TSP-1 expression strongly correlates with fibrogenesis and angiogenesis in experimental cirrhosis.

In the view of the authors, the results of this study suggest TSP-1 might contribute to the wound healing response to liver injury as an inducer of angiogenesis, and could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.

The fact chronic inflammatory liver diseases respond poorly to immunosuppressive and anti-inflammatory therapy shows angiogenesis might be a promising therapeutic target in the prevention of fibrosis. Recently, several antiangiogenic therapeutic strategies have been shown to suppress liver fibrosis development in experimental studies.

Using an experimental model, this research was performed by doctors from the Department of Pathology of the Faculty of Medicine at the University of Akdeniz, Antalya, Turkey.

Further research should explain the exact role of TSP-1 in hepatic angiogenesis, and whether this protein could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Best Practice Database: Complimentary Excerpt of Ensuring a Successful New Product Launch Through Effective Processes and Authority Roles
2. Is extra-corporal liver support with prometheus safe in patients with end-stage liver disease?
3. Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM)
4. Risk threshold of daily alcohol intake and drinking duration in liver injury?
5. Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
6. AmeriCares Delivers Life-Saving Aid to Myanmar
7. Supreme Master Ching Hai International Association Delivering US$160,000 in Aid to Earthquake Survivors in China
8. Suicide Prevention Group Delivers Much-Needed Message to Pennsylvanias Elderly
9. Mercy Corps Delivers Lifesaving Supplies to China Earthquake Survivors
10. Embryonic pathway delivers stem cell traits
11. Four Rivers Software Systems Delivers TMS Enterprise 2008.3.4
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, ... with The Jensie Gran Fondo of Marin. For the second year in a ... broad-spectrum, mineral-based sunscreen. , “We are thrilled to provide our safe, non-toxic sunscreen ...
(Date:2/23/2017)... ... 2017 , ... The Lymphoma Research Foundation (LRF) – the ... the lymphoma community through a comprehensive series of education programs, outreach initiatives and ... Beach to host its Swirl: Miami Wine Tasting Event on March 28, 2017. ...
(Date:2/23/2017)... ... 23, 2017 , ... Los Angeles-based weight loss surgeon Michael Feiz, M.D., F.AC.S. ... Not to Hot,” which will begin airing on February 24, 2017. The show chronicles ... the 2012 reality television series, “Here Comes Honey Boo Boo.” The earlier series from ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... for the National Institute for Health and Care Excellence (NICE) framework. ... the National Health Service (NHS) to search, order and purchase medical and healthcare-related ...
(Date:2/23/2017)... ... February 23, 2017 , ... Pink Pig Publishing LLC announces ... and explore the world from different perspectives. By providing a place for people ... understanding, increase empathy, and find greater happiness. , "Our approach to structuring ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , 23. Februar 2017 Im Rahmen ... nationale Wirtschaftszone in der südwestlichen chinesischen Provinz Guizhou, 2017 mit ... einer Innovationsplattform aktiv an der Entwicklung einer eingebetteten Hightech-Schlüsselindustrie. ... Continue Reading ... ...
(Date:2/23/2017)... VALLEY COTTAGE, New York , February 23, 2017 ... to health implications arising from increasing caseload for varicose ... cases recorded across the globe are prompting the adoption ... A latest study on global endovenous laser therapy ... growing attention towards aftereffects of lifestyle choices and consequences ...
(Date:2/23/2017)... WASHINGTON , Feb. 23, 2017  As ... tips.  In addition, the Company is helping people ... through its customized prescription savings programs in all ... Florida Prescription Assistance Program  and  California Prescription Assistance ... tips from Columbia University for nutritious ...
Breaking Medicine Technology: