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What roles does TSP-1 play in liver fibrogenesis?

In rats with diethyl nitrosamine induced cirrhosis, TSP-1 expression has been found to correlate with the progression of fibrosis. Furthermore, TSP-1 expression was higher in rat livers with high vascular densityin other words, angiogenesis. This study, performed by a team led by Dr. Glsm zlem Elpek, is described in a research article to be published on April 14, 2008 in the World Journal of Gastroenterology.

Thrombospondin 1 (TSP-1) is involved in complex processes including wound healing and angiogenesis. In non-neoplastic diseases of the liver, although the association of TSP-1 with latent transforming growth factor - beta1 (TGF- beta1) has been demonstrated in a few studies, the relationship between TSP-1 and angiogenesis during liver fibrogenesis has not been documented.

TSP-1 expression strongly correlates with fibrogenesis and angiogenesis in experimental cirrhosis.

In the view of the authors, the results of this study suggest TSP-1 might contribute to the wound healing response to liver injury as an inducer of angiogenesis, and could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.

The fact chronic inflammatory liver diseases respond poorly to immunosuppressive and anti-inflammatory therapy shows angiogenesis might be a promising therapeutic target in the prevention of fibrosis. Recently, several antiangiogenic therapeutic strategies have been shown to suppress liver fibrosis development in experimental studies.

Using an experimental model, this research was performed by doctors from the Department of Pathology of the Faculty of Medicine at the University of Akdeniz, Antalya, Turkey.

Further research should explain the exact role of TSP-1 in hepatic angiogenesis, and whether this protein could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis.


Contact: Jing Zhu
World Journal of Gastroenterology

Page: 1

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