Navigation Links
What makes fructose fattening? OHSU researchers find some answers in the brain
Date:2/9/2011

PORTLAND, Ore. The dietary concerns of too much fructose is well documented. High-fructose corn syrup has become the sweetener most commonly added to processed foods. Many dietary experts believe this increase directly correlates to the nation's growing obesity epidemic. Now, new research at Oregon Health & Science University demonstrates that the brain which serves as a master control for body weight reacts differently to fructose compared with another common sweetener, glucose. The research is published in the online edition of the journal Diabetes, Obesity and Metabolism and will appear in the March print edition.

"We know from animal models that the brain responds uniquely to different nutrients and that these responses can determine how much they eat," said Jonathan Purnell, M.D., an associate professor of medicine (endocrinology, diabetes and clinical nutrition) in the OHSU School of Medicine.

"With newer technologies such as functional MRI, we can examine how brain activity in humans reacts when exposed to, say, carbohydrates or fats. What we've found in this case is that the brain's response to fructose is very different to the response to glucose, which is less likely to promote weight gain."

Functional MRI allows researchers to watch brain activity in real time. To conduct the research, nine normal-weight human study subjects were imaged as they received an infusion of fructose, glucose or a saline solution. When the resulting brain scans from these three groups were compared, the scientists observed distinct differences.

Brain activity in the hypothalamus, one brain area involved in regulating food intake, was not affected by either fructose or glucose. However, activity in the cortical brain control areas showed the opposite response during infusions of the sugars. Activity in these areas was inhibited when fructose was given but activated during glucose infusion.

This is an important finding because these control brain areas included sites that are thought to be important in determining how we respond to food taste, smells, and pictures, which the American public is bombarded with daily.

"This study provides evidence in humans that fructose and glucose elicits opposite responses in the brain. It supports the animal research that shows similar findings and links fructose with obesity," added Purnell.

"For consumers, our findings support current recommendations that people be conscious of sweeteners added to their drinks and meals and not overindulge on high-fructose, processed foods."


'/>"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Getting to the scientific heart of what makes romantic relationships succeed or fail
2. Watching TV coverage of terror makes viewers feel threatened
3. Medicare Makes Way for Baby Boomers
4. Being faced with gender stereotypes makes women less likely to take financial risks
5. Sleep makes your memories stronger
6. University of East Anglia makes cancer breakthrough
7. CIHR makes recommendations on Canadian MS research priorities
8. Study suggests oxytocin makes people trusting, but not gullible
9. Infidelity Rises When She Makes More Than He Does
10. Licensed Florida Tech research makes lab work easier
11. New method of tissue banking makes gene analysis more practical for lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... “Three Narrow Roads”: a vivid ... creation of published author, Rev. Dr. Burnett King Sr., is currently the pastor-teacher-visionary at ... of the Faith Track Club, Inc., a track-and-field program geared towards youth. , King ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Depressed: Super Heroes of the Bible”: ... upon the stories and the relevance these tales may have on the reader’s life. ... a former special education teacher, Jessica spends much of her time enjoying nature and ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Kingdom Mandate for Kingdom Builders”: a call to ... for Kingdom Builders” is the creation of published author, John F. McGeorge, Jr. ... a missionary in 1983. He spent three decades training pastors and Christian leaders. ...
(Date:8/18/2017)... ... 2017 , ... “Steve the Snake”: an entertaining and moral-based short story about ... published author, Harold Flash Haskins Jr., a husband, father and grandfather who served as ... “I write moral-based short stories for children and teens. My goal is to teach ...
(Date:8/17/2017)... ... 2017 , ... Riccobene Associates Family Dentistry, the Research Triangle’s ... its family of practices. Residents of Goldsboro will be able to experience the ... , Riccobene Associates Family Dentistry, founded by Dr. Michael Riccobene in 2000, prides ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: DPLO), is ... residents. Naloxone is available without ... retail pharmacy, G-3320 Beecher Road. ... Drug Administration, is intended to block or reverse the ... loss of consciousness. The medication is often carried by ...
(Date:8/11/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... today announced that it will release its second quarter ... conference call at 9:00am ET. The Company will discuss ... its strategy and outlook for the remainder of 2017. The ... , Chief Executive Officer, and Zvi Ben-David , ...
(Date:8/7/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... its Board of Directors has approved the payment of a ... 2017. The cash dividend ... October 27, 2017 to stockholders of record as of the ... dividends are subject to approval of the Board of Directors ...
Breaking Medicine Technology: