Navigation Links
What makes cell division accurate?
Date:1/23/2014

Baltimore, MD As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies.

New research from a team led by Carnegie's Yixian Zheng focused on one important part of this process. Her results improve our understanding of how cell division gives rise to two daughter cells with an equal complement of chromosomes. It is published by Developmental Cell.

Cell division is helped along by a complex of more than 90 proteins, called a kinetochore, interacting with scaffolding-like structural fibers called microtubules. Together the kinetochore and microtubules provide the structure and force that pull the two duplicate halves of the chromosome apart and direct them to each daughter cell.

By looking beyond the microtubules and kinetochores themselves, Zheng's team identified a protein that regulates the interactions between the kinetochore and the microtubule fibers. Using super resolution microscopy, they were able to hone in on one particular phase of this process, namely the way that microtubules are "captured" by the kinetochore to promote proper alignment of the chromosomes in a way that facilitates equal partition of duplicated DNA.

"The study of mitosis has focused on microtubules and kinetochores, the most prominent structure that researchers observe. Our work demonstrates the importance of expanding the scope of study to include other cellular components because this is critical to achieving an in depth understanding of the mechanisms underlying chromosome alignment in preparation for dividing the DNA into two new cells." Zheng said.


'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Practice makes perfect if you have a partners touch, according to new study
2. InventHelp Client Introduces Kit - Invention Makes Nebulizer Masks More Child-Friendly (AUP-318)
3. Collection of Long Island Hearing Aid Reviews from East End Hearing Makes Selecting an Audiologist and a First Hearing Aid Easier
4. Green Park & Golf Ventures Makes a Major Investment in Socrates Health Solutions
5. PolyU Expert Makes First Space Tool for Lunar Exploration
6. Renegade Diabetes Company DollarDiabetesClub.com Breaks Barriers to Glucose Testing; New Online Club Makes Daily Glucose Testing Affordable for Everyone
7. Gaspari Nutrition Makes Waves at the 2013 World Jiu Jitsu Expo
8. Dr. Steven Weiner Discusses the New FDA Approved Dermal Filler, Voluma, and What Makes It Different Than the Other Fillers
9. Midmark Corporation Makes Donation to The Ohio State University College of Medicine to Foster Efficient, Effective Patient Care
10. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
11. Life-Changing Ringing Cedars of Russia Book Series Makes the Perfect Holiday Gift
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What makes cell division accurate?
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made their ... to an ambitious venture that conjoined the passions of an NBA star, a Liberty ... Liberty community. These shoes will save lives from the rampant infections transmitted through the ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... a highly specialized asset-light logistics provider of complex transport solutions for mission-critical ... to purchase Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... of “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the importance ... for individuals with hearing impairments and shares the latest innovations in hearing aid ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... handheld devices. Through an educational webinar, they will present the line of epMotion ... to learn how easy you can automate everyday pipetting tasks. , Ideal for ...
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez Insurance ... to communities throughout the greater DC region, is inaugurating a “New Leash On ... local animals and training them to be companions for veterans in need. , ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... as president, effective Aug. 7, 2017. ... to pursue other interests and will serve as president emeritus ... has served us in multiple leadership roles since he joined ... 2015 and has provided decisive, strategic leadership which continues to ...
(Date:8/4/2017)... CINCINNATI , Aug. 3, 2017  Agragen, ... science company active in the biopharmaceutical, nutraceutical, and ... its development of its lead drug candidates, AGR131.  ... a proinflammatory cytokine from the blood of patients ... psoriasis, and inflammatory bowel disease. ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: