Navigation Links
What keeps a cell's energy source going
Date:11/27/2012

PHILADELPHIA Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell's energy storehouse the mitochondria -- is important for understanding a cell's normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.

Two years ago, Kevin Foskett, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania, and colleagues discovered that fundamental control of ATP production is an ongoing shuttle of calcium to the mitochondria from another cell compartment. They found that mitochondria rely on this transfer to make enough ATP to support normal cell metabolism.

Foskett's lab and the lab of colleague Muniswamy Madesh, PhD, at Temple University, discovered last month an essential mechanism that regulates the flow of calcium into mitochondria, described in the October 26 issue of Cell. They found that the mitochondrial protein MICU1 is required to establish the proper level of calcium uptake under normal conditions.

In a new paper out this week in Nature Cell Biology, the same Penn-Temple team describe a new protein and its function. Like MICU1, this new protein, MCUR1, interacts physically with MCU, the uniporter calcium ion channel within the mitochondria. Calcium uptake is driven by a voltage across the inner mitochondrial membrane and mediated by the calcium-selective ion channel called the uniporter.

"But this newly described protein, MCUR1, has the opposite role as MICU1," notes Foskett. "It seems to be a subunit that, together with MCU, is required for a functional uniporter calcium channel."

Many cell plasma membrane ion channels also have subunits that are required for those channels to work. Before this paper, there was no realization that this mitochondrial channel, MCU, did as well.

Maintaining the
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. A fish a day keeps the doctor away?
2. Playing Several Sports Keeps Kids Slimmer: Study
3. Weight loss today keeps the doctor away
4. Cost Keeps Many Americans From Good Dental Care: Report
5. Oxytocin keeps flirting folks at arms length
6. New drug prevents spread of human prostate cancer cells
7. Tiny hitchhikers attack cancer cells
8. To prevent leukemias dreaded return, go for the stem cells
9. Scientists identify major source of cells defense against oxidative stress
10. Therapy exploits addiction of leukemia cells
11. IBN discovers human neural stem cells with tumor targeting ability
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What keeps a cell's energy source going
(Date:8/28/2015)... ... August 28, 2015 , ... Popular review site Top5MillionaireDatingSites.com ... dating sites . According to the listings, MillionaireMatch.com bags the top ... , A spokesperson of Top5MillionaireDatingSites.com said, “This website has been designed ...
(Date:8/28/2015)... Texas (PRWEB) , ... August 28, 2015 , ... Yisrayl ... a new publication and pleads for swift actions to be taken in order ... unnatural disasters. , Yisrayl says scientists have yet to understand fully the real ...
(Date:8/28/2015)... ... August 28, 2015 , ... Super-Sod launched their new website ... The most notable change is the responsive web design. Website users will now have ... easily submit quote requests for sod, sign-up for the monthly turf-tips email, and find ...
(Date:8/28/2015)... ... ... Santa Rosa was recently recognized, for the fourth consecutive year, as one ... “2015 Midterm Performance Review: Software & Services”, Santa Rosa achieved the highest rating of ... KLAS are directly related to our company culture.” said Richard Helppie, chairman and chief ...
(Date:8/27/2015)... ... August 28, 2015 , ... Shortening the school ... performance in mathematics, according to researchers at Georgia State University and Montana State ... July, analyzed the impact of a four-day school week on student achievement by ...
Breaking Medicine News(10 mins):Health News:Top5MillionaireDatingSites.com Publishes Its First List of Reviews of the Best Millionaire Dating Sites 2Health News:Wake Up and Smell the Sick Atmosphere Says Yisrayl Hawkins in New Article This Week 2Health News:Santa Rosa Consulting Recognized by Modern Healthcare as One of the Top 100 Best Places to Work and from KLAS Research with the Highest Rating for Go-Live Support 2Health News:Four-Day School Week Can Improve Academic Performance, Study Finds 2Health News:Four-Day School Week Can Improve Academic Performance, Study Finds 3
... Va., April 10 - The National,Community Pharmacists Association ... incumbent representing North Carolina,s 3rd,Congressional District, who has ... community pharmacies and their patients. He is facing ... on May 6. Bruce,Roberts, RPh, executive vice president ...
... examination by independent ... auditors, ... auditors as a result of its first Type,II SAS 70 compliance audit. ... a major U.S. accounting firm over a,period of five months. The audit ...
... , The removal through endoscopy of tumours that ... avoid complete extirpation of this part of the digestive ... of Navarra for the last three years, was presented ... the Digestive System, organized by the Digestive System Service ...
... researchers have identified a mating mechanism that possibly,could ... the,viruses that cause dengue fever, second only to ... tropical world. , Specifically, they have discovered 63 ... during mating and are thought,briefly to change the ...
... 10 The Deafness Research,Foundation (DRF) is hosting a ... achievements in hearing health and research,and to inaugurate the ... Foundation is one of the largest and oldest,hearing research ... a,lifetime of hearing health possible for all people through ...
... significantly reduce total cost of ... ... announced that Chicago-based uBid, which helps sellers and,manufacturers liquidate excess inventory, ... replace both its Oracle,E-Business Suite enterprise resource planning system and its ...
Cached Medicine News:Health News:GHX Achieves SAS 70 Compliance 2Health News:Removal of superficial tumors in esophagus by endoscopy can avoid extirpation of this part 2Health News:Removal of superficial tumors in esophagus by endoscopy can avoid extirpation of this part 3Health News:Removal of superficial tumors in esophagus by endoscopy can avoid extirpation of this part 4Health News:Mosquito mating mechanism could lead to new attack on dengue and yellow fever 2Health News:Deafness Research Foundation 50th Anniversary Celebration 2Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 2Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 3Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 4Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 5Health News:Asset-Recovery Leader Chooses Microsoft Dynamics AX and CRM Online 6
(Date:8/28/2015)... , August 28, 2015 The ... Livestock (Pork/Swine, Poultry, Ruminant, and Aquaculture), & by Region ( ... Asia-Pacific , and Rest of the World) ... The global market for Eubiotics was valued at USD 4.62 ... Billion by 2020, at a CAGR of 7.4% from 2015 ...
(Date:8/28/2015)... FRANCISCO , August 28, 2015 ... expected to reach USD 49.12 billion by 2020, growing ... according to a new report by Grand View Research, ... estimated CAGR of 49.7% from 2014 to 2020. ... Growing aging population along with rising incidences of chronic ...
(Date:8/27/2015)... CUPERTINO, Calif. , Aug. 27, 2015 ... management is scheduled to present at three upcoming healthcare ... , President and CEO, will present at the Rodman ... 10:00 a.m. Eastern time. The conference is being held ... York City . A live audio webcast of ...
Breaking Medicine Technology:Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5DURECT to Participate in Upcoming Healthcare Conferences 2
... for Cancer Research and Education (FCRE) announced today that,prostate ... on new treatments for prostate cancer at Westminster at ... PM., "With the recent press around prostate cancer ... "The good news is there are many,things people can ...
... new Mayo,Clinic study found that regular physical exercise ... of the brain that affects nerve cells,involved in ... the,American Academy of Neurology Annual Meeting in Chicago ... impairment can function reasonably well,in everyday activities, but ...
Cached Medicine Technology:Free Prostate Cancer Seminar in Lake Ridge, VA: Dr. Charles 'Snuffy' Myers Announces Vitamin D Clinical Trials 2Mayo Clinic Finds Exercise Can Reduce the Risk of Mild Cognitive Impairment 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: