Navigation Links
What is the pathogenesis of C. jejuni-related disease?
Date:12/31/2008

Campylobacters are small Gram-negative spiral rods. Campylobacter jejuni (C. jejuni), a foodborne organism contracted from untreated water, milk and meat, especially chicken, is one of the most important causes of bacterial diarrhea worldwide. However, its mode of pathogenesis is not clear.

A research article to be published on December 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Christopher J Hawkey from Nottingham University Hospital of United Kingdom investigated whether different strains isolated from patients with Campylobacter infection had different effects.

Nineteen consecutive strains from community patients with acute bacterial enteritis were isolated and three of them were compared with the laboratory strain 12189. All strains translocated across monolayers but only a minority invaded HCA-7 cells. Strains that invaded HCA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate. dehydrogenase, a four-fold increase in permeability to (3H) mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not.

Their results indicated that two distinct patterns of interaction between clinical isolates of C. jejuni and a colonic epithelial cell line. Strains that invaded epithelial cells were shown to destroy them, Strains that did not invade epithelial cells did not affect barrier properties or increase mediator production. The data raised the possibility that with some Campylobacter infections the epithelian can be the source of pro-secretory and pro-inflammatory compounds.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
2. Could preserving biodiversity reduce disease?
3. Herbal remedy reduces obesity and heart disease?
4. Is extra-corporal liver support with prometheus safe in patients with end-stage liver disease?
5. How to manage Chinese obese children with non-alcoholic fatty liver disease?
6. How does P wave dispersion change in patients with Wilsons disease?
7. Does artificial intelligence help clinicians to recognize atrophic gastritis with thyroid disease?
8. Might fish provide Lowe-down on boyhood disease?
9. The missing link between belly fat and heart disease?
10. How do patients choose the best treatment for their disease?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... (MRE), is pleased to be invited to the Siemens Healthineers annual customer education ... The event will take place from March 27 - 31, 2017 at ...
(Date:3/28/2017)... ... March 29, 2017 , ... The Thyroid Secret is a ... FASCP. The program was recently launched on March 1, and Dr. Wentz discussed ... , Dr. Izabella Wentz is a licensed pharmacist and a foremost thyroid ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... all holidays (IBT World Travel Trends Report). As travelers visit both urban destinations, ... in temperatures, and prolonged sun exposure. In response, the outdoor industry has blurred ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... society dedicated to advancing the science and clinical practice of radiosurgery, announced ... Patient Registry, a multi-institutional, observational registry established to standardize data collection from ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., ... (Mobile Personal Emergency Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products ... first of their kind, the iSAFE and iSAFE Plus offer direct GPS Location and ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... 28, 2017  Rosen Law Firm, a global investor ... action lawsuit on behalf of purchasers of Kitov Pharmaceutical ... and/or traceable to Kitov,s initial public offering on or ... open market from November 20, 2015 through February 3, ... seeks to recover damages for Kitov investors under the ...
(Date:3/28/2017)... March 29, 2017 Center Point ... CRO platform, announced today study results presented in ... Pharmacy, #AMCP2017, Managed Care and Specialty Pharmacy annual ... Data in both posters demonstrated that pharmacist-led patient interventions ... adherence. These factors are crucial to generating the robust ...
(Date:3/28/2017)... and TEL AVIV, Israel , March ... subsidiary in Israel . This new business entity, ... be mostly dedicated to research and development of novel assays complementing ... will also, when relevant, locally support commercialization and sales development of ... This ...
Breaking Medicine Technology: