Navigation Links
What is the mechanism of the chronic radiation enteritis?
Date:12/23/2008

The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment have been well established, a number of patients experience distressing complications as a result injury to normal tissue These side effects related to inflammatory process cause discomfort and decreases the therapeutic benefit by increasing the overall treatment time.

A research article to be published on December 14, 2008 in the World Journal of Gastroenterology addresses the question. The research led by Dr. Christine Linard and her colleagues from the Institute for Radioprotection and Nuclear safety (IRSN) in France used experimentally a fractionated colorectal irradiation model to demonstrate an immune imbalance during the radiotherapy protocol and persisting in long term.

They found that without causing histological damage, fractionated radiation induced elevated expression of IL-1beta, TNF alpha, MCP-1, and iNOS in distal colonic mucosa during the early post-irradiation phase. At that time, a Th2 profile was confirmed by expression of both the Th2-specific transcription factor GATA-3 and the chemokine receptor CCR4 and by suppression of the Th1 cytokine IFN gamma/IP-10 throughout the irradiation protocol. After 6 mo, despite the 2-fold reduction of iNOS and MCP-1 levels, the Th2 profile persisted, as shown by a 50% reduction in the expression of the Th1 transcription factor T-bet, the chemokine receptor CCXCR3, and the IFNgamma /STAT1 pathway. At the same time-point, the immunosuppressive IL-10/STAT3 pathway, known to regulate the Th1/Th2 balance, was expressed, in irradiated rats, at approximately half its level as compared to controls. This suppression was associated with an overexpression of SOCS3, which inhibits the feedback of the Th1 polarization and regulates IL-10 production.

The major result is that the immunity alteration persisted in long term, i.e. after the end of the radiotherapy protocol. These data raise the question whether the post-irradiation Th2 polarization in the intestine (both acute and delayed) may result from changes in the dynamics of lymphocyte recirculation.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
2. Portuguese scientists discover new mechanism that regulates formation of blood vessels
3. USC researchers identify key mechanism that regulates the development of stem cells into neurons
4. Simple brain mechanisms explain arbitrary human visual decisions
5. Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis
6. PET scans help identify mechanism underlying seasonal mood changes
7. NIH scientists find a novel mechanism that controls the development of autoimmunity
8. Scripps research team unravels new cellular repair mechanism
9. Researchers find differences in swallowing mechanism of Rett syndrome patients
10. Brain Mechanism Can Turn Off Trauma of Bad Memories
11. Insight into mechanisms of diabetes-induced microvascular disease reveals new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... ... Park Systems , a leader in Atomic Force Microscopy (AFM) since ... Park customers on July 11, 2017 from 12-2pm at the Thirsty Bear Brewing Company. ... Park Systems, and Prof. Krishna Saraswat , Rickey/Nielsen Professor in the School of ...
(Date:6/28/2017)... , ... June 28, 2017 , ... ... and financial consultations to communities in northern Virginia and DC, is announcing a ... provide for patients with Alzheimer’s and other disorders that lead to memory impairment. ...
(Date:6/27/2017)... PA and London UK (PRWEB) , ... June 27, 2017 , ... ... applying to a clinical study is whether they can trust the sponsor to pay ... it is vital that sponsors and CROs establish payment strategies that encourage sites to ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... SUNucate efforts, Louisiana became the sixth state to pass legislation which ensures ... John Bel Edwards’ signature, Louisiana joins the states of Alabama, Arizona, Florida, Utah ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... and personal financial planning services to residents of southern New Hampshire, is teaming ... that promises to fight hunger and homelessness in the region. , New Horizons ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders or ... manufacture, sale and distribution of the AeroForm® Tissue Expander ... its commercial roll-out in the United States ... one hundred (100) medical institutions and health systems, located ... needle-free alternative for women who choose reconstructive surgery following ...
(Date:6/8/2017)...  Less than a month ago, amateur hackers executed ... including hospital networks, in over 150 countries. ... largest online extortion attempts ever recorded. With the increasing ... imperative that providers understand where the risks lie, and ... and many other very real cyber threats.  ...
(Date:6/8/2017)... Texas , June 8, 2017 /PRNewswire/ ... a leading developer and manufacturer of diagnostic ... announced today that Cressey & Company LP ... firm, has completed a growth-focused investment in ... a majority ownership position from selling shareholder, ...
Breaking Medicine Technology: