Navigation Links
What is the clinical features of primary aortoenteric fistula?
Date:9/24/2008

PAEF is a rare but often life-threatening cause of massive gastrointestinal bleeding. PAEFs have a mortality rate of nearly 100% in the absence of surgical intervention, and in most case, the diagnosis is not established preoperatively. This report presents one such case wherein the cause of death was PAEF-induced massive gastrointestinal bleeding that occurred after discharge of the patient from the hospital. Few previous reports on PAEF provide both the clinical course, including gastrointestinal endoscopic findings, and detailed autopsy findings.

A research team was led by Dr. Ihama address this case and was published on August 7, 2008 in the World Journal of Gastroenterology.

They found that a considerable number of sudden and unexpected deaths have occurred due to PAEFs in cases wherein the diagnosis had not been established. The incidence of PAEF is probably higher than estimated. Moreover, PAEF is a fatal but not an untreatable gastrointestinal disease. However, a PAEF patient cannot be saved without early diagnosis because only an appropriate and urgent surgical invention can rescue the patient. The classical triad of symptoms, i.e., gastrointestinal bleeding, abdominal pain, and a pulsating abdominal mass is probably overemphasized because it occurs in less than 25% of PAEF cases. On the contrary, PAEFs usually present with a herald bleed prior to exsanguination, which is usually minor and self-limiting. If PAEF is diagnosed simultaneously with the herald bleeding, surgical therapy may salvage many patients of PAEF.

Endoscopy is generally the most preferred primary procedure and provides valuable information in cases of gastrointestinal bleeding. In PAEF patients, absence of identifiable bleeding lesions on initial gastrointestinal endoscopy is regarded by clinicians as a strong indicator for laparotomy. However, gastrointestinal endoscopy may be a double-edged sword when PAEFs coexist with multiple bleeding sites. Furthermore, even detection of coexisting bleeding sites by upper endoscopy or colonoscopy, even by capsule endoscopy, may be misleading. Ultimately, the key to early diagnosis of PAEF is endoscopist's heightened index of suspicion; therefore, endoscopists need to recognize PAEF as a potential cause of gastrointestinal bleeding. This article is a valuable step to publicize PAEF.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Medicare HMO costs may prevent cancer patient clinical trial participation
2. DIA Conference to Present Latest Strategies in Clinical Trial Disclosure Compliance
3. Novel tuberculosis vaccine in Germany in clinical phase
4. Adhesion Prevention New Major Market Opportunity, Haemacure Confirms Effectiveness of its Fibrin Sealant in Second Preclinical Study in Adhesion Prevention in a Bleeding Model
5. Oncology Clinical Research Scientist Recommends a Nuanced Preclinical Study Process to Speed Drug Development
6. VCU Massey Cancer Center spearheads novel clinical study for lymphoma patients
7. Shaping Best Practices For Standardized Medical Imaging In Clinical Trials
8. New probe to detect skin cancer receives more funding for clinical trials
9. Prototype test for predicting clinical outcome for melanoma patients
10. Analysis of Six Clinical Trials Finds EPZICOM(R) Effective in Treatment-Naive HIV Patients With Both High and Low Baseline Viral Loads
11. Clinical Research Management gets contract for trials of therapeutics against infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... 06, 2016 , ... From May 4 to 6, EarQ and ... opportunity to learn more about Signia’s technology and the successful business and marketing techniques ... priority to see practices succeed in this highly competitive industry,” said Ed Keller, president ...
(Date:5/6/2016)... Arizona (PRWEB) , ... May 06, 2016 , ... ... moved domains to Sleepopolis.com . , Since launching in September, 2014 Sleepopolis ... research and testing areas, which now include pillows, sheets, mattress toppers, bed frames, ...
(Date:5/6/2016)... , ... May 06, 2016 , ... ... online provider of career-focused education and corporate training, and the National Military Family ... to announce Maritza Aquino as the second full-tuition scholarship recipient of 2016. ...
(Date:5/6/2016)... ... May 06, 2016 , ... RowdMap, Inc. ... Cross BlueShield and Former Principal Deputy Administrator at Centers for Medicare and Medicaid ... Steve Ondra, MD, Chief Medical Officer at Health Care Service Corporation (Blue Cross ...
(Date:5/5/2016)... ... May 05, 2016 , ... Qrono Inc. , ... a development collaboration with the Australian critical medicine company, Phebra Pty Ltd. ... , LAI medicines can offer improved therapeutic benefits over oral formulations, including better ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research and Markets has announced ... in the USA"  report to their offering.  ,     (Logo: ... the current Positron Emission Tomography (PET) scanner and cyclotron ... market. Along with the current known number of PET ... , the report also contains a detailed breakdown of ...
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocytopenia Market and ... to their offering.       ... ,The latest research Europe Thrombocytopenia Market ... provides comprehensive insights into Thrombocytopenia pipeline ...
(Date:5/4/2016)... Conn., May 4, 2016  Compass Diversified Holdings (NYSE: ... "Company"), an owner of leading middle market businesses, announced ... ended March 31, 2016. First Quarter 2016 ... and Reinvestment ("CAD" or "Cash Flow") of $13.6 million ... net loss of $15.0 million for the first quarter ...
Breaking Medicine Technology: