Navigation Links
What is the clinical features of primary aortoenteric fistula?

PAEF is a rare but often life-threatening cause of massive gastrointestinal bleeding. PAEFs have a mortality rate of nearly 100% in the absence of surgical intervention, and in most case, the diagnosis is not established preoperatively. This report presents one such case wherein the cause of death was PAEF-induced massive gastrointestinal bleeding that occurred after discharge of the patient from the hospital. Few previous reports on PAEF provide both the clinical course, including gastrointestinal endoscopic findings, and detailed autopsy findings.

A research team was led by Dr. Ihama address this case and was published on August 7, 2008 in the World Journal of Gastroenterology.

They found that a considerable number of sudden and unexpected deaths have occurred due to PAEFs in cases wherein the diagnosis had not been established. The incidence of PAEF is probably higher than estimated. Moreover, PAEF is a fatal but not an untreatable gastrointestinal disease. However, a PAEF patient cannot be saved without early diagnosis because only an appropriate and urgent surgical invention can rescue the patient. The classical triad of symptoms, i.e., gastrointestinal bleeding, abdominal pain, and a pulsating abdominal mass is probably overemphasized because it occurs in less than 25% of PAEF cases. On the contrary, PAEFs usually present with a herald bleed prior to exsanguination, which is usually minor and self-limiting. If PAEF is diagnosed simultaneously with the herald bleeding, surgical therapy may salvage many patients of PAEF.

Endoscopy is generally the most preferred primary procedure and provides valuable information in cases of gastrointestinal bleeding. In PAEF patients, absence of identifiable bleeding lesions on initial gastrointestinal endoscopy is regarded by clinicians as a strong indicator for laparotomy. However, gastrointestinal endoscopy may be a double-edged sword when PAEFs coexist with multiple bleeding sites. Furthermore, even detection of coexisting bleeding sites by upper endoscopy or colonoscopy, even by capsule endoscopy, may be misleading. Ultimately, the key to early diagnosis of PAEF is endoscopist's heightened index of suspicion; therefore, endoscopists need to recognize PAEF as a potential cause of gastrointestinal bleeding. This article is a valuable step to publicize PAEF.


Contact: Lai-Fu Li
World Journal of Gastroenterology

Related medicine news :

1. Medicare HMO costs may prevent cancer patient clinical trial participation
2. DIA Conference to Present Latest Strategies in Clinical Trial Disclosure Compliance
3. Novel tuberculosis vaccine in Germany in clinical phase
4. Adhesion Prevention New Major Market Opportunity, Haemacure Confirms Effectiveness of its Fibrin Sealant in Second Preclinical Study in Adhesion Prevention in a Bleeding Model
5. Oncology Clinical Research Scientist Recommends a Nuanced Preclinical Study Process to Speed Drug Development
6. VCU Massey Cancer Center spearheads novel clinical study for lymphoma patients
7. Shaping Best Practices For Standardized Medical Imaging In Clinical Trials
8. New probe to detect skin cancer receives more funding for clinical trials
9. Prototype test for predicting clinical outcome for melanoma patients
10. Analysis of Six Clinical Trials Finds EPZICOM(R) Effective in Treatment-Naive HIV Patients With Both High and Low Baseline Viral Loads
11. Clinical Research Management gets contract for trials of therapeutics against infectious diseases
Post Your Comments:
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated ... latest FDA requirements, which stipulates new criteria regarding medical device manufacture ... Medical ID jewelry such as Medical ID Bracelets, can rest assured ... of the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process ...
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
Breaking Medicine Technology: