Navigation Links
What is the best treatment for children with vesicoureteral reflux?
Date:5/20/2010

New York, NY, May 20, 2010 . Children with vesicoureteral reflux (VUR), in which urine flows backwards into the kidneys from the bladder, have been treated in the past with surgery or antibiotic therapy. Although this condition can lead to renal damage, there have been few controlled studies to help determine the most effective treatment of young children. A study, part of the Swedish Reflux Trial, is scheduled for publication in the July 2010 issue of the Journal of Urology.

Investigators from the Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Sweden, led a national study in which 203 children with VUR were followed in a randomized clinical trial (128 girls and 75 boys). One-third received prophylactic antibiotics, one-third received endoscopic intervention and one-third was observed with no treatment.

"Controlled studies are needed to provide an evidence base for treatment in children with VUR," according to lead investigator Sverker Hansson, MD. "The Swedish Reflux Trial was set up as a RCT to compare long-term antibiotic prophylaxis, endoscopic correction and surveillance as the control group in children with dilating VUR in regard to the febrile UTI rate, and kidney and VUR status at 2 years. Secondary outcomes were complications and the impact of factors such as VUR grade, gender and bladder dysfunction. In the current report we analyzed the progression of renal defects present at entry and the development of new renal damage in the 3 treatment groups."

The researchers found that the rate of new renal damage in boys was low, with only one boy who received endoscopic treatment and one on surveillance having further damage. In girls the rate was higher (13 or 10%) and there was a significant difference between treatment groups with new damage most common in controls on surveillance. New damage was observed in 19% of girls on surveillance, 12% who received endoscopic treatment and in none on prophylaxis.

There was a strong association between recurrent febrile urinary tract infections (UTI) and new renal damage in girls but recurrent UTIs and new damage were unusual in boys. The febrile UTI rate differed significantly between treatment groups in girls, including a recurrence rate of 57% in the surveillance, 23% in the endoscopic and 19% in the prophylactic groups.

Dr. Hansson and co-investigators state, "An interesting finding was that new damage as well as the progression of previously observed renal uptake defects was only seen in kidneys drained by ureters with dilating VUR with 1 exception. There was no difference in this respect whether VUR was grade III or IV at study entry. Previously unscarred kidneys were as vulnerable to new renal damage as those with uptake defects at entry."


'/>"/>

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Post-Chemo Treatment May Boost Lung Cancer Survival
2. Book Delivers Latest ADHD Research, Treatments & Results
3. Early Treatment With Clot-Busting Drug Best After Stroke
4. CIGNA and Cancer Treatment Centers of America Reach New Agreement
5. New hope for better treatment for a rising cancer
6. Passages to Recovery Outdoor Addiction Treatment Program Achieves Joint Commission Accreditation
7. New technology aids in prostate cancer treatment
8. Impotence Drugs May Aid Brain Tumor Treatment
9. Self-directed behavioral IBS treatment rapidly relieves even the most severe symptoms
10. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
11. Smarter use of existing treatment helps dramatically boost survival of young AML patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... ... and HR decision-makers are preparing for how his administration could impact the employee ... insight into what changes are most likely to make it through Congress. His ...
(Date:4/25/2017)... Las Vegas, NV (PRWEB) , ... April 25, ... ... teeth can now choose a modern procedure that achieves results in a fraction ... orthodontist in Las Vegas, NV, with Significance Dental Specialists, now offers this ...
(Date:4/25/2017)... ... April 25, 2017 , ... Buyers and sellers in the ... dispensaries and head shops –can’t help but be heartened by the industry’s current surge. ... odor aptly described as “skunk smell.” At last they can simply, safely and ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... There is ... Regional Hospital, according to a special report in the May issue of Consumer Reports ... its highest quality ranking for results achieved during and after coronary bypass and aortic ...
(Date:4/24/2017)... ... 2017 , ... LG CNS Healthcare Solutions debuted the next ... Telehealth 2.0, the American Telemedicine Association’s national conference. , BYOD has been added ... pre-programmed tablet in a remarkably easy-to-use kit for patients. “BYOD is the next ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2014 ... ... US$ 7,167.6 Mn in 2015, and is expected to reach ... 5.6% from 2016 to 2024. The global ...
(Date:4/19/2017)... April 19, 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) ... & Co. Healthcare Investor Conference 2017 at the Sheraton Hotel in ... , Chief Executive Officer of the Company is scheduled to present ... Richard Bear and the Chairman of the Board, Tony ... ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 ... Surgical drainage devices are tubes used to remove excess ... include, blood, serum, pus, urine, bile or lymph. Surgical ... types of surgery such as orthopedics surgery, cardiovascular surgery, ... device is prophylactic post-surgery to prevent accumulation of fluid ...
Breaking Medicine Technology: