Navigation Links
What is the best treatment for children with vesicoureteral reflux?
Date:5/20/2010

New York, NY, May 20, 2010 . Children with vesicoureteral reflux (VUR), in which urine flows backwards into the kidneys from the bladder, have been treated in the past with surgery or antibiotic therapy. Although this condition can lead to renal damage, there have been few controlled studies to help determine the most effective treatment of young children. A study, part of the Swedish Reflux Trial, is scheduled for publication in the July 2010 issue of the Journal of Urology.

Investigators from the Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Sweden, led a national study in which 203 children with VUR were followed in a randomized clinical trial (128 girls and 75 boys). One-third received prophylactic antibiotics, one-third received endoscopic intervention and one-third was observed with no treatment.

"Controlled studies are needed to provide an evidence base for treatment in children with VUR," according to lead investigator Sverker Hansson, MD. "The Swedish Reflux Trial was set up as a RCT to compare long-term antibiotic prophylaxis, endoscopic correction and surveillance as the control group in children with dilating VUR in regard to the febrile UTI rate, and kidney and VUR status at 2 years. Secondary outcomes were complications and the impact of factors such as VUR grade, gender and bladder dysfunction. In the current report we analyzed the progression of renal defects present at entry and the development of new renal damage in the 3 treatment groups."

The researchers found that the rate of new renal damage in boys was low, with only one boy who received endoscopic treatment and one on surveillance having further damage. In girls the rate was higher (13 or 10%) and there was a significant difference between treatment groups with new damage most common in controls on surveillance. New damage was observed in 19% of girls on surveillance, 12% who received endoscopic treatment and in none on prophylaxis.

There was a strong association between recurrent febrile urinary tract infections (UTI) and new renal damage in girls but recurrent UTIs and new damage were unusual in boys. The febrile UTI rate differed significantly between treatment groups in girls, including a recurrence rate of 57% in the surveillance, 23% in the endoscopic and 19% in the prophylactic groups.

Dr. Hansson and co-investigators state, "An interesting finding was that new damage as well as the progression of previously observed renal uptake defects was only seen in kidneys drained by ureters with dilating VUR with 1 exception. There was no difference in this respect whether VUR was grade III or IV at study entry. Previously unscarred kidneys were as vulnerable to new renal damage as those with uptake defects at entry."


'/>"/>

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Post-Chemo Treatment May Boost Lung Cancer Survival
2. Book Delivers Latest ADHD Research, Treatments & Results
3. Early Treatment With Clot-Busting Drug Best After Stroke
4. CIGNA and Cancer Treatment Centers of America Reach New Agreement
5. New hope for better treatment for a rising cancer
6. Passages to Recovery Outdoor Addiction Treatment Program Achieves Joint Commission Accreditation
7. New technology aids in prostate cancer treatment
8. Impotence Drugs May Aid Brain Tumor Treatment
9. Self-directed behavioral IBS treatment rapidly relieves even the most severe symptoms
10. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
11. Smarter use of existing treatment helps dramatically boost survival of young AML patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: