Navigation Links
What identifies cancer cells causing relapse and metastasis? Not CD133
Date:5/22/2008

New data, generated by Shahin Rafii and colleagues, at Weill Medical College of Cornell University, New York, through analysis of human colon cancer cells and mice, have shed doubt on the recently proposed designation of the protein CD133 as a marker of colon cancer stem cells a term given to the small number of cells within a colon cancer that are thought to be able to give rise to a new tumor and that therefore are responsible for tumor recurrence and metastasis.

In the study, mice were engineered such that they expressed a reporter protein everywhere that CD133 is normally expressed. In contrast to previous studies in which CD133 expression had been shown to be expressed by very few cells in the colon, this reporter protein was detected in many cells in the colon, including nonstem cells. A similarly broad expression of CD133 in the colon of both mice and humans was observed using antibodies that bind CD133. Analysis of human and spontaneous mouse primary colon tumors indicated that CD133 was expressed by most cells. Conversely, not all human colon cancer cells that had metastasized to the liver expressed CD133. Further, both the CD133+ and CD133 cells generated tumors when transplanted into immunocompromised mice. Some of the reasons why this study and previous investigations reached such distinct conclusions as to whether or not CD133 is a marker of colon cancer stem cells are noted by the authors and discussed in detail in an accompanying commentary by Mark LaBarge and Mina Bissell, at Lawrence Berkeley National Laboratory, Berkeley.


'/>"/>

Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo Clinic Research Shows U.S. Intensive Care Units Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement
2. Study identifies molecular response of cartilage to injury
3. Flip Flops, Mulch and No Coat: Study Identifies Surprising Barriers to Outdoor Activity for Kids in Child-Care Centers
4. OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
5. Mayo Clinic identifies treatment target for liver cancer recurrence and survival
6. Mayo Clinic Identifies Infection Risks for Patients with Inflammatory Bowel Disease
7. Study identifies mechanism underlying multidrug resistance in fungi
8. Scientists: New technique identifies molecular biomarkers for disease
9. FDA Identifies Contaminant in Blood-Thinning Drug
10. Iowa State University researcher identifies eye disease in canines
11. Study identifies reasons patients referred late to nephrologists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ... August 23, 2017 , ... ... , has returned home to Indiana, and is now seeing patients at Boling ... ophthalmologist that specializes in the diagnosis and treatment of eye disease, medical retina, ...
(Date:8/23/2017)... ... August 23, 2017 , ... A ... of Orthopaedic Surgeons , points out that therapeutic modalities (physical therapy) is an ... According to the report, a wider scope of physical therapy options is showing ...
(Date:8/22/2017)... ... August 22, 2017 , ... Western North ... at a popular international aesthetics conference for medical professionals about the positive impact ... health and his growing practice. , Dr. George K. Ibrahim shared ...
(Date:8/22/2017)... ... August 22, 2017 , ... Five Star Glass is new to the Texas market, but ... of auto glass for most makes and models, in Grand Prairie, TX, located in the ... They have been a family owned business for the past 40 years with 32 convenient ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “Glimpses Of ... understanding of the world. “Glimpses Of Light” is the creation of published author, J.M. ... life in search of answers to life’s perplexing mysteries. , Shepherd shares, “Love is ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... MEMPHIS, Tenn. and BENTON, Ky. , Aug. 2, 2017 /PRNewswire/ ... new member to its environmental services (ES) team to proactively reduce the risk of hospital-acquired ... is a UV disinfection robot that uses UVC light energy to kill deadly pathogens such ... ... Tru-D ...
(Date:7/31/2017)... 31, 2017 Three Tru-D SmartUVC robots have arrived ... Korea . Tru-D, short for "Total Room Ultraviolet Disinfection," is a ... an environmental services (ES) professional cleans the area with traditional cleaning protocols. ... Tru-D fights germs ... "Although the BAACH has a very ...
(Date:7/27/2017)... Services, Inc. (NYSE: WST ) today announced ... financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a record high, ... constant currency (organic) grew by 3.9%. ... in the prior-year quarter. Second-quarter 2017 adjusted diluted EPS ...
Breaking Medicine Technology: