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What emotional memories are made of
Date:10/4/2007

that cage and put them back in it the next day, mice who had received adrenaline or fox urine tended to freeze in fear an indicator they associated the cage as the site of a shock more frequently, suggestive of enhanced memory.

However, in a similar experiment with mice genetically engineered to have a defective GluR1 receptor that phosphates cannot attach to, adrenaline injections had no effect on mouse memory, further evidence of the priming effect of the receptor in response to norepinephrine.

The researchers plan on continuing their work by going in the opposite direction and engineering another mouse strain that has a permanently phosphorylated or primed receptor. Were curious to see how these mice will behave, Huganir says. We suspect that theyll be pretty smart, but at the same time constantly anxious.


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Contact: Nick Zagorski
nzagors1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

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