Navigation Links
What do rotten eggs and colon cancer have in common?
Date:7/8/2013

University of Texas Medical Branch at Galveston researchers have discovered that hydrogen sulfide the pungent-smelling gas produced by rotten eggs is a key player in colon cancer metabolism, and a potential target for therapies for the disease.

In a paper appearing online this week in the Proceedings of the National Academy of Sciences, the UTMB scientists describe cell-culture and mouse experiments demonstrating that colon cancer cells produce large amounts of hydrogen sulfide, and depend on the compound for survival and growth.

"They love it and they need it," said UTMB professor Csaba Szabo, an author on the paper. "Colon cancer cells thrive on this stuff our data show that they use it to make energy, to divide, to grow and to invade the host."

The researchers connected the bulk of colon-cancer hydrogen sulfide production to a protein called CBS, which is produced at much higher levels in colon cancer cells than in non-cancerous tissue. Experiments revealed that colon cancer cell growth was curtailed when the activity of CBS was chemically blocked, while normal cell growth was unaffected.

"Our work identifies CBS as a new anti-cancer target," said UTMB professor and paper author Mark Hellmich. "By blocking CBS, we can fight colon cancer."

The anti-colon cancer effects of blocking CBS were also seen when the scientists studied "nude" mice onto which patient-derived colon cancer tumor cells had been implanted. Without hydrogen sulfide, the tumors grew much more slowly. They also showed a pronounced decrease in angiogenesis the process by which a tumor stimulates the growth of a host's blood vessels around itself to "hijack" oxygen and nutrients for its own use.

The discovery surprised Szabo and Hellmich, but in retrospect, Szabo said, it makes sense. "Billions of years ago, before there was oxygen on Earth, hydrogen sulfide biochemistry was one of the main mechanisms that supported life," Szabo said. "By producing hydrogen sulfide, cancer cells are recreating an ancient mechanism."

That mechanism, Hellmich said, offers the scientists a chance to translate a basic science discovery into new therapies for cancer patients. "This is a chance to do research that really matters," Hellmich said. "We're very excited to have that opportunity."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. U.S. Supreme Court Rules Generic Drug Makers Can’t Be Sued for Design Defects Under State Law, Rottenstein Law Group LLP Reports
2. Rottenstein Law Group LLP Acknowledges BMJ Study of Risks of Byetta, Januvia
3. Transvaginal Mesh Lawsuit Update: Rottenstein Law Group LLP Encouraged by $55 Million Endo Health Settlement
4. Wright Hip Implant News: Rottenstein Law Group LLP Comments on Hip Division Sale
5. Lipitor News: Rottenstein Law Group LLP Comments on Boomers’ Favorite Drug
6. Rottenstein Law Group LLP Comments on News Reports of Mirena IUD Side Effects
7. Transvaginal Mesh Lawsuit News: NJ Mesh Consolidation Cases Moving Along, Rottenstein Law Group LLP Reports
8. NuvaRing Lawsuit News: First New Jersey NuvaRing Trial Scheduled to Start This Week, Rottenstein Law Group LLP Reports
9. Rottenstein Law Group LLP Announces New Tylenol Lawsuit Center
10. Actos Lawsuit News: Plaintiff Claims Actos Causes Bladder Cancer, Rottenstein Law Group LLP Reports
11. Rottenstein Law Group LLP Comments on Drugmakers’ Cooperation With Safety Review of Byetta, Januvia, Victoza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... New York, NY (PRWEB) , ... December 07, ... ... measurable amounts of the drug in their bodies, a researcher at the Icahn ... the journal Pediatric Research. , The study found that when young children are ...
(Date:12/7/2016)... ... December 07, 2016 , ... In the early morning of ... an emergency medical call when he lost control of his patrol car. The vehicle ... his vehicle, he was transported to Atlanta Medical Center, where he later succumbed to ...
(Date:12/7/2016)... ... December 07, 2016 , ... They are musicians and librarians, ... wives, brothers and fathers, from New England and around the nation. What do they ... are brought together in a beautiful and compelling new photographic exhibit debuting Friday, December ...
(Date:12/7/2016)... ... 07, 2016 , ... Augustine Insurance Agency, a locally owned ... owners in the greater Dallas metropolitan area, is announcing a charity event that ... Established in 2009 by active police professionals in the Dallas region, the Dallas ...
(Date:12/7/2016)... , ... December 07, 2016 , ... Sharon Kleyne, host ... Climate Change and Your Health on Voice of America, declared on her radio program ... attention to the fact that when these bullies attack leaders in corporate America, they ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 2016 According to the latest ... Market Study on Multiplex Detection Immunoassay: North America to ... global multiplex detection immunoassay market is expected to witness a CAGR ... ...      (Logo: http://photos.prnewswire.com/prnh/20161114/438683LOGO) ...
(Date:12/7/2016)... 2016 The global  blood ... of USD 3.9 billion by 2024, based on ... The growth of the market is attributed to ... advancements by the market players. Demand for blood ... donation, rising awareness about transfusion-transmitted diseases, and technological ...
(Date:12/6/2016)... 6, 2016  Alopexx Oncology, LLC announced data from ... fusion protein (immunocytokine) composed of interleukin-2 and a CD20-targeting ... on B cells as Rituxan and maintains the activities ... also involved in tumor targeting, engagement of the immune ... results of the study (abstract #95954) were presented at ...
Breaking Medicine Technology: