Navigation Links
What do rotten eggs and colon cancer have in common?
Date:7/8/2013

University of Texas Medical Branch at Galveston researchers have discovered that hydrogen sulfide the pungent-smelling gas produced by rotten eggs is a key player in colon cancer metabolism, and a potential target for therapies for the disease.

In a paper appearing online this week in the Proceedings of the National Academy of Sciences, the UTMB scientists describe cell-culture and mouse experiments demonstrating that colon cancer cells produce large amounts of hydrogen sulfide, and depend on the compound for survival and growth.

"They love it and they need it," said UTMB professor Csaba Szabo, an author on the paper. "Colon cancer cells thrive on this stuff our data show that they use it to make energy, to divide, to grow and to invade the host."

The researchers connected the bulk of colon-cancer hydrogen sulfide production to a protein called CBS, which is produced at much higher levels in colon cancer cells than in non-cancerous tissue. Experiments revealed that colon cancer cell growth was curtailed when the activity of CBS was chemically blocked, while normal cell growth was unaffected.

"Our work identifies CBS as a new anti-cancer target," said UTMB professor and paper author Mark Hellmich. "By blocking CBS, we can fight colon cancer."

The anti-colon cancer effects of blocking CBS were also seen when the scientists studied "nude" mice onto which patient-derived colon cancer tumor cells had been implanted. Without hydrogen sulfide, the tumors grew much more slowly. They also showed a pronounced decrease in angiogenesis the process by which a tumor stimulates the growth of a host's blood vessels around itself to "hijack" oxygen and nutrients for its own use.

The discovery surprised Szabo and Hellmich, but in retrospect, Szabo said, it makes sense. "Billions of years ago, before there was oxygen on Earth, hydrogen sulfide biochemistry was one of the main mechanisms that supported life," Szabo said. "By producing hydrogen sulfide, cancer cells are recreating an ancient mechanism."

That mechanism, Hellmich said, offers the scientists a chance to translate a basic science discovery into new therapies for cancer patients. "This is a chance to do research that really matters," Hellmich said. "We're very excited to have that opportunity."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. U.S. Supreme Court Rules Generic Drug Makers Can’t Be Sued for Design Defects Under State Law, Rottenstein Law Group LLP Reports
2. Rottenstein Law Group LLP Acknowledges BMJ Study of Risks of Byetta, Januvia
3. Transvaginal Mesh Lawsuit Update: Rottenstein Law Group LLP Encouraged by $55 Million Endo Health Settlement
4. Wright Hip Implant News: Rottenstein Law Group LLP Comments on Hip Division Sale
5. Lipitor News: Rottenstein Law Group LLP Comments on Boomers’ Favorite Drug
6. Rottenstein Law Group LLP Comments on News Reports of Mirena IUD Side Effects
7. Transvaginal Mesh Lawsuit News: NJ Mesh Consolidation Cases Moving Along, Rottenstein Law Group LLP Reports
8. NuvaRing Lawsuit News: First New Jersey NuvaRing Trial Scheduled to Start This Week, Rottenstein Law Group LLP Reports
9. Rottenstein Law Group LLP Announces New Tylenol Lawsuit Center
10. Actos Lawsuit News: Plaintiff Claims Actos Causes Bladder Cancer, Rottenstein Law Group LLP Reports
11. Rottenstein Law Group LLP Comments on Drugmakers’ Cooperation With Safety Review of Byetta, Januvia, Victoza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... , ... April 22, 2017 ... ... of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its “Woman-Owned ... PROSHRED® Philadelphia specializes in providing information destruction , recycling, and ...
(Date:4/21/2017)... , ... April 21, 2017 , ... An April 10 ... a pair of ancient teeth, which reveal a great deal about prehistoric ice-age dental ... sharp stone may have been used to remove decayed dental matter, and that teeth ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. ... osteoma is a benign bony lump located on the forehead usually attributed to a ... with sight and pain. Dr. Shah has discovered an approach that is minimally invasive. ...
(Date:4/21/2017)... ... 21, 2017 , ... Dudnyk has announced the launch of its new brand ... full potential of specialty and orphan brands can only be achieved when the needs ... Unifying Effect is at the heart of a true partnership between our agency and ...
(Date:4/21/2017)... ... , ... The Hong Kong Polytechnic University (PolyU) launched today the University Research ... in Hong Kong to support teaching, learning and research. It is also the largest ... in Hong Kong. , With an area of 620 square metres and more ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical results demonstrating anti-fibrotic effects with NV556, ... (NASH), in an additional well-validated experimental NASH ... previously shown similar anti-fibrotic effects in the ... present novel data demonstrating anti-fibrotic effects of ...
(Date:4/19/2017)... Cardiology devices segment is anticipated to reach the ... Cardiology Devices segment is likely to create absolute $ opportunity ... over 2017. By the end of 2027, Cardiology Devices segment ... 700 Mn, expanding at a CAGR of 18.4% over the ... Asia Pacific reprocessed medical devices market in terms ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 ... Surgical drainage devices are tubes used to remove excess ... include, blood, serum, pus, urine, bile or lymph. Surgical ... types of surgery such as orthopedics surgery, cardiovascular surgery, ... device is prophylactic post-surgery to prevent accumulation of fluid ...
Breaking Medicine Technology: