Navigation Links
What do rotten eggs and colon cancer have in common?

University of Texas Medical Branch at Galveston researchers have discovered that hydrogen sulfide the pungent-smelling gas produced by rotten eggs is a key player in colon cancer metabolism, and a potential target for therapies for the disease.

In a paper appearing online this week in the Proceedings of the National Academy of Sciences, the UTMB scientists describe cell-culture and mouse experiments demonstrating that colon cancer cells produce large amounts of hydrogen sulfide, and depend on the compound for survival and growth.

"They love it and they need it," said UTMB professor Csaba Szabo, an author on the paper. "Colon cancer cells thrive on this stuff our data show that they use it to make energy, to divide, to grow and to invade the host."

The researchers connected the bulk of colon-cancer hydrogen sulfide production to a protein called CBS, which is produced at much higher levels in colon cancer cells than in non-cancerous tissue. Experiments revealed that colon cancer cell growth was curtailed when the activity of CBS was chemically blocked, while normal cell growth was unaffected.

"Our work identifies CBS as a new anti-cancer target," said UTMB professor and paper author Mark Hellmich. "By blocking CBS, we can fight colon cancer."

The anti-colon cancer effects of blocking CBS were also seen when the scientists studied "nude" mice onto which patient-derived colon cancer tumor cells had been implanted. Without hydrogen sulfide, the tumors grew much more slowly. They also showed a pronounced decrease in angiogenesis the process by which a tumor stimulates the growth of a host's blood vessels around itself to "hijack" oxygen and nutrients for its own use.

The discovery surprised Szabo and Hellmich, but in retrospect, Szabo said, it makes sense. "Billions of years ago, before there was oxygen on Earth, hydrogen sulfide biochemistry was one of the main mechanisms that supported life," Szabo said. "By producing hydrogen sulfide, cancer cells are recreating an ancient mechanism."

That mechanism, Hellmich said, offers the scientists a chance to translate a basic science discovery into new therapies for cancer patients. "This is a chance to do research that really matters," Hellmich said. "We're very excited to have that opportunity."


Contact: Jim Kelly
University of Texas Medical Branch at Galveston

Related medicine news :

1. U.S. Supreme Court Rules Generic Drug Makers Can’t Be Sued for Design Defects Under State Law, Rottenstein Law Group LLP Reports
2. Rottenstein Law Group LLP Acknowledges BMJ Study of Risks of Byetta, Januvia
3. Transvaginal Mesh Lawsuit Update: Rottenstein Law Group LLP Encouraged by $55 Million Endo Health Settlement
4. Wright Hip Implant News: Rottenstein Law Group LLP Comments on Hip Division Sale
5. Lipitor News: Rottenstein Law Group LLP Comments on Boomers’ Favorite Drug
6. Rottenstein Law Group LLP Comments on News Reports of Mirena IUD Side Effects
7. Transvaginal Mesh Lawsuit News: NJ Mesh Consolidation Cases Moving Along, Rottenstein Law Group LLP Reports
8. NuvaRing Lawsuit News: First New Jersey NuvaRing Trial Scheduled to Start This Week, Rottenstein Law Group LLP Reports
9. Rottenstein Law Group LLP Announces New Tylenol Lawsuit Center
10. Actos Lawsuit News: Plaintiff Claims Actos Causes Bladder Cancer, Rottenstein Law Group LLP Reports
11. Rottenstein Law Group LLP Comments on Drugmakers’ Cooperation With Safety Review of Byetta, Januvia, Victoza
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I ... Bronx, N.Y. “I thought there had to be a convenient and comfortable way to ... The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. In ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing ... this disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely ... resulting in a way for homeless people to have a more dignified and ... new initiative whereby they are repurposing plastic bags into sleeping mats for the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since ... providing comprehensive solutions involving adult stem cell therapies to patients with chronic degenerative ... “Regenestem” name as a Registered Trademark (RTM). , Organizations are required to hold ...
(Date:11/24/2015)... (PRWEB) , ... November 25, 2015 , ... ... and monitoring. Their Care Plan software creates an agreement between the practice ... care plan, including financial, scheduling, monitoring, notification, and projections. Click here ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... and BERN, Switzerland , November ... ARTORG Center for Biomedical Engineering Research of the University ... Division of Endocrinology, Diabetes and Clinical Nutrition of the ... start of an exclusive collaboration to develop a novel ... for the personalised delivery of insulin for diabetic patients ...
(Date:11/24/2015)... FLINT, Mich. , Nov. 24, 2015 Diplomat ... , Senior Vice President of Clinical Services, Education and Human ... (AIS) online webinar, "Oral Oncology Drugs: Health Plan Strategies for ... co-presenting with Beckie Fenrick , a consultant with the ... The webinar will ...
(Date:11/24/2015)... 24, 2015 iRhythm Technologies, Inc. , a leading ... announced that it will participate in the 27th Annual Piper Jaffray ... New York, NY . Kevin King , Chief ... 1, 2015 at 8:50am ET. --> ... . --> . --> iRhythm is ...
Breaking Medicine Technology: