Navigation Links
What are the essential characteristics of serum PG in Chinese?
Date:1/16/2008

Pepsinogen (PG) is a precursor for pepsin, a digestive enzyme specifically produced in the gastric mucosa. Human PG can be classified into two different biochemical and immunological properties, PGI and PGII. Serum PG levels seem to be related to the morphologic and functional changes in the stomach, and used as "serological biopsy." In most Western countries, serum PG testing has been focused on the identification of individuals for intervention studies, whereas in Japan it is used as a part of gastric cancer screening. However, the limited knowledge about serum PG characteristics in Chinese may prejudice the assessment of consistency.

A research article to be published on December 28, 2007 in the World Journal of Gastroenterology (volume 13, issue 48) addresses this question. The research team, led by Prof. Yuan Yuan from China Medical University, spent more than 6 years working with a total of 6990 subjects who underwent large-scale surveys of gastric cancer. The large sample size allowed them to obtain results with high statistical significance and draw very reliable conclusions.

One conclusion reported by the investigators is the essential characteristics of serum PG levels in Chinese are significantly skewed from the normal distribution, and influenced by age, sex, gastric mucosa lesions and H pylori infection. However, thorough investigation is needed for researchers to identify the normal distribution in different age and gender groups by stratification. The investigators suggested these factors, such as being of the male sex, age > 60 years, atrophic lesion and H pylori infection, should be taken into account in the screening of gastric cancer by PG test.

Another conclusion is that PG I/II ratio is better than either PG I or PG II alone in reflecting the development of atrophic lesions on gastric mucosa. Thus, it is can be used for further investigation as a screening tool in the first period.

In this study, the essential characteristics of serum PG in Chinese are described. The results suggest a practical future of serum PG I/II ratio as an effective serological indicator for identifying subgroups with different influence factors. The population-based study reported by Prof. Yuan Yuan is surely of interest to the public and medical professional involved in gastric cancer screening in China.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Colorectal cancer screening remains essential for elderly Americans
2. New Report Finds Information Technology Essential But Not Sufficient in Long-Term Care
3. Walgreens Launches New Health Essentials Catalog and Website for AARP Members Featuring More Than 20,000 Health-Related Products
4. Sign Up Now for Project Management Essentials - Three Days of Training in IT Project Management Fundamentals
5. Early treatment of children with bilateral amblyopia essential, according to multisite study
6. Nourishment Is Essential to a Youthful Appearance. Time to Feed Your Face with Serum_G
7. Isolation of a new gene family essential for early development
8. Serum carcinoembryonic antigen level can reflect adrenal adenoma
9. Panacea Pharmaceuticals Announces the Availability of CC Detect(SM), a Serum-Based Diagnostic Test for Colon Cancer
10. Data Show Vaprisol(R) Is Effective & Safe in Promptly Increasing Serum Sodium Levels in Patients With Euvolemic or Hypervolemic Hyponatremia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: