Navigation Links
What are the Real Benefits Versus Risks of Preventative Brain Radiation for Patients With Non-Small Cell Lung Cancer?

CHICAGO, Nov. 2 /PRNewswire-USNewswire/ -- Patients with non-small cell lung cancer treated with preventative brain radiation (called prophylactic cranial irradiation or PCI), significantly decrease their risk of developing brain metastases (cancer spread in the brain) by more than 50 percent (from 18 percent to 8 percent), compared to those who did not receive the treatment, according to a randomized study presented at the plenary session November 2, 2009, at the 51st Annual Meeting of American Society for Radiation Oncology (ASTRO).

While there were no significant differences in quality of life, patients who received PCI did have a significantly increased risk of short and long-term memory loss. The study also found that patients who underwent PCI did not live longer than patients who did not receive this treatment.

"This is the first randomized study to analyze neurocognitive and quality of life factors for non-small cell lung cancer patients who undergo PCI," Benjamin Movsas, M.D., presenter of this Radiation Therapy Oncology Group (RTOG) study and chairman of radiation oncology at Henry Ford Hospital in Detroit said. "With better, more targeted treatments, more lung cancer patients are surviving longer and are at increased risk of developing brain metastases. This study provides key information that will lead to a better understanding of the true risks versus benefits of this intervention."

PCI is a preventative type of external beam radiation therapy that treats the entire brain to try to sterilize potential invisible tumor cells that are so small they cannot even be seen on sensitive imaging tests. The risk of cancer developing in the brain increases as people with non-small cell lung cancer are surviving longer due to more effective treatments.

In this study, 340 eligible patients from 127 RTOG institutions with Stage III non-small cell lung cancer whose cancer had not progressed after undergoing treatment were randomized to be treated with PCI or undergo observation from September 2002 to August 2007.

"It's critical for studies to not only report on patient outcomes, such as local control and survival, but also on how the treatments affect the patients, including neurocognition and quality of life factors," Dr. Movsas said. "We need the 'whole picture' in order to be able to accurately assess and discuss treatment options with our patients."

The study was supported by grants from the National Cancer Institute.

For more information on radiation therapy for lung cancer, visit

The abstract, "Phase III Study of Prophylactic Cranial Irradiation (PCI) versus Observation in Patients with Stage III Non-Small Cell Lung Cancer (NSCLC): Neurocognitive and Quality of Life (QOL) Analysis of RTOG 0214," was presented at the plenary session at 2:15 p.m. on Monday, November 2, 2009. To speak to the presenter of the study, Benjamin Movsas, M.D., please call Beth Bukata or Nicole Napoli November 1-4, 2009, in the ASTRO Press Room at McCormick Place West at 312-791-7005 or 312-791-7006. You may also e-mail them at <u>bethb@astro.or</u><u>g</u> or

SOURCE American Society for Radiation Oncology

SOURCE American Society for Radiation Oncology
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Practice-based intervention has sustained benefits for children and families
2. Manic phase of bipolar disorder benefits from breast cancer medication
3. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
4. Smaller breast reduction surgeries provide health benefits and should be reimbursed
5. Cholesterol byproduct blocks heart health benefits of estrogen
6. A Place for Mom, Nations Largest Senior Care Referral Service, Fills a Gap in Employee Benefits
7. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
8. Hazards of using crib bumper pads outweigh their benefits
9. Dominium Benefits Experiencing Dynamic Growth
10. The Integrated Benefits Institute Offers Largest Benchmarking Database in U.S. Spanning Disability and Workers Compensation Programs
11. Physiotherapy has short-term benefits for patients after knee surgery
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... Dental Association meeting in Washington D.C. revolved around the fact that proper dental care, ... The talk stressed the link between periodontal disease (more commonly referred to as gum ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... and convenient way to dispense prescription medications at home, so he invented the ... to monitor and dispense prescription medications. In doing so, it could help to ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that ... ). More than 3.7 billion people under the age of 50 – or 67% ... WHO's first global estimates of HSV-1 infection . , "The data shocks us highly!" ...
(Date:11/27/2015)... ... 2015 , ... Keeping in mind challenges faced by parents ... consultation, has collaborated with a leading web-based marketplace for extra-curricular activities for children ... and bring advice from parenting experts within their reach. As a part of ...
(Date:11/27/2015)... ... ... Indosoft Inc., developer and distributor of the world-class Asterisk ... Term Support) into its Q-Suite 5.10 product line. , Making the change to ... of Asterisk that will receive not only security fixes, but feature and bug ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... WASHINGTON , Nov. 25, 2015  The ... Obstetricians and Gynecologists (ACOG), and the March of ... bipartisan Protecting Our Infants Act of 2015 ... the number of newborns born exposed to drugs, ... Since the bill,s introduction, all three organizations have ...
(Date:11/25/2015)... Nov. 25, 2015 On Tuesday, November ... bellwether trial against Wright Medical Technology, Inc. for ... Conserve metal-on-metal hip implant device, awarded $11 million ... two week trial and three days of deliberations, ... device was defectively designed and unreasonably dangerous, and ...
(Date:11/25/2015)... Israel , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused ... treatment of various clinical conditions, today announced the closing ... American Depository Shares ( ADSs ), each representing 20 ... up to 3,158,900 ADSs. The ADSs and warrants were ...
Breaking Medicine Technology: