Navigation Links
What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?
Date:2/22/2008

5-fluorouracil (5-FU) is a common chemotherapeutical drug. It exerts its antitumor effect through competitive thymidylate synthase (TS) inhibition. Thymidylate synthase (TS) catalyses deoxyuridine-5-monophosphate (dUMP) to 2-deoxythymydine-5-monophosphate (dTMP). It is the only de novo source of thymidylate, an essential precursor of DNA biosynthesis. In the 5-untranslated region of TS gene, there a unique tandem repeated sequence. There are three predominant genotypes of TS: (1) Homozygous with two tandem repeats (2R/2R); (2) homozygous with three tandem repeats (3R/3R); (3) heterozygous with both alleles (2R/3R). It was reported that TS genes with the triple repeats have higher expression activity than those with double repeats in vitro and in vivo.

The critical role of TS in nucleotide metabolism has made it an important target for cancer chemotherapy. Intratumoral TS protein expression before the chemoradiation treatment has been observed to inversely correlate with the response to 5-FU chemotherapy. Patients with low TS levels have better clinical outcome than those with high TS levels. Detecting the intratumoral TS levels is important for patients who are going to receive 5-FU-based chemotherapy, as these can be used to forecast the efficacy of chemotherapy. However, the classical assay for TS-activity determination (high-performance liquid chromatography with output monitored by radioactive flow detector) is tedious and expensive. A simple way to detect the TS levels is necessary. A research article to be published on January 28, 2008 in the World Journal of Gastroenterology addresses this question.

Immunoreactivity score (IRS) is a semiquantitative analysis for detecting the immunostaining results. Dr.Wei-Xing Wang and his colleagues used monoclonal antibody TS106 to detect the TS protein in the paraffin-embedded specimens. The samples came from 68 colonic neoplasms of Han Chinese patients. At the same time, the team also observed t
'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New FIRST RESPONSE(R) Pregnancy Test Gives Women a Fast and Simple One-Word Answer
2. Dental Devices Offer a Simple Solution for Sleep
3. 6 simple steps to protect against and stop the spread of noroviruses
4. Simple online methods increase physician disease reporting
5. 10-fold life span extension reported in simple organism
6. Simple test accurately predicts risk of serious jaundice in newborns
7. Ring In 2008 With Simple New Years Resolutions That Will Stick Year-Round
8. Simple strategy could prevent half of deadly tuberculosis infections
9. be(R) is Making Health Simple With Complimentary, Expert Online Diet, Nutrition and Exercise Advice
10. YMCA of the USA Offers Simple Tips to Give the Lifetime Gift of Health and Well-Being to Family and Friends This Holiday Season
11. Simple Tips Keep the Flu at Bay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 30, 2014 According to Bloomberg ... that requires Takeda Pharmaceutical Co. and Eli Lilly & ... claims that the drugmakers concealed information about a risk ... The case, Allen v. Takeda Pharmaceuticals North America Inc. ... District of Louisiana (Lafayette).* , According to Bloomberg, Takeda ...
(Date:8/30/2014)... Recently, Skmen.com, a well-known clothing manufacturer, has ... . Before the middle of September, all the company’s ... from 15 to 30 percent off. , As ... outfits are carefully made and come with quality guarantees. ... wearers. Skmen.com is popular for its fashionable, high quality ...
(Date:8/30/2014)... CA (PRWEB) August 30, 2014 Ticket Down ... vs. Chile exhibition match next Saturday at Levi's Stadium. ... for diehard soccer fans in the United States due to the ... in just about every major city. Many of these games ... in Brazil this past summer. , Levi’s Stadium is a brand ...
(Date:8/30/2014)... 2014 Information supplied by insurance companies ... better prices to consumers in 2014. A group of ... when using the open system for adults at ... to use this year can help the average person ... location and not from medical histories. The finder tool ...
(Date:8/30/2014)... 2014 United Theological Seminary is pleased to ... the Master of Theological Studies (MTS). , ... designed for students who wish to pursue further academic study ... to serve the Church and community. Previously, students needed to ... can attend classes from any location where there is an ...
Breaking Medicine News(10 mins):Health News:The Law Office of Melinda J. Helbock A.P.C. Comments on Decision to Uphold $9 Billion Actos Award 2Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:Mexico vs. Chile Tickets at Levi's Stadium in Santa Clara, CA: TicketDown.com Offers Promo Code for Mexico vs. Chile Exhibition Game on September 6th 2Health News:Term Life Insurance Rates Now Found Nationally by New Insurer Finder Tool 2Health News:United Theological Seminary Announces First Fully Online Degree 2
... a particular genetic variation may be tied to an ... ,Known medically as premenstrual dysphoric disorder, or PMDD, this ... their childbearing years. It's characterized by bouts of major ... half of the menstrual cycle. These symptoms settle with ...
... that the notorious incident of her arrest for shoplifting from a ... a blessing for her because it got rid of her dependence ... has talked about her arrest, an incident that got a lot ... that just before her arrest, she got hooked to some painkillers ...
... singer, says that men are not safe in Bollywood, ... attentions of many people. Sonu Nigam has accused a senior ... in return for publicity. ,The casting couch is a ... girls in the industry. , ,Sonu Nigam accuses ...
... Bill Clinton will on Friday launch a multi-million dollar ... dogged by poor facilities and a brain drain . ... ceremony for the construction of the modern hospital which ... Chaponda told AFP Thursday. ,The Clinton/Hunter Initiative ...
... North Korea's state media on Thursday talked up the virtues ... delicacy for coping with the summer heat . ... best cuisine" served over the summer season, the official Korean ... ,Dangogi, literally meaning sweet meat, is an euphemism for dog ...
... are puzzling over the case of 44-year-old civil servant who ... extraordinarily tiny brain . ,In a case history ... of the Hopital de la Timone in Marseille say the ... his left leg. ,Scans by computed tomography (CT) ...
Cached Medicine News:Health News:Genetic Variation may Increase Premenstrual Depression Risk 2Health News:Genetic Variation may Increase Premenstrual Depression Risk 3Health News:Winona Ryders Arrest Got Her Rid of Drug Dependence 2Health News:Male Casting Couch in Bollywood? 2Health News:Male Casting Couch in Bollywood? 3
(Date:8/29/2014)... 29, 2014 Diseases largely eradicated in ... are returning. Measles was declared eliminated in 2000, yet ... of August 15—the highest incidence in 20 years. In ... declared whooping cough a problem of "epidemic proportions." ... and dying from these preventable diseases—in part because some ...
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "Global Multiple Sclerosis Drugs Market 2014-2018" ... is a chronic, inflammatory medical condition that results in ... damaged because of an abnormal response by the immune ... (CNS). It is a potentially debilitating disease in which ...
(Date:8/29/2014)... PASO ROBLES, Calif. , Aug. 29, 2014 /PRNewswire/ ... launch of its new website design . The ... an overhaul that showcases the company,s new services and ... By implementing a new streamlined design, viewers can ... deliver metrics for health care practices and create a ...
Breaking Medicine Technology:Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3PMDS Announces New Website 2
... CHAPEL HILL, N.C., Nov. 21, 2011  In today,s payer-driven ... success of a new pharmaceutical product. However, sustaining commercial ... and processes that will increase market share after the ... half of practices to manage the challenges of the ...
... N.J., Nov. 21, 2011  Watson Pharmaceuticals, Inc. (NYSE: ... today that Paul Bisaro, Watson,s President and Chief Executive ... Company,s business at the 2011 Piper Jaffray Health Care ... EST at the New York Palace Hotel in New ...
Cached Medicine Technology:Managed Care Pull-Through Programs Target Physicians, Boost Market Share 2
... The Minifold I system consists of four basic ... plenum, and metal clamping plate (see diagram). The ... for producing spots, dots, or slots (see below). ... purchased as an accessory plate in conjunction with ...
... The Minifold I system consists of four basic ... plenum, and metal clamping plate (see diagram). The ... for producing spots, dots, or slots (see below). ... purchased as an accessory plate in conjunction with ...
... Bio-Dot SF (slot format) microfiltration units provide ... nucleic acid in solution onto nitrocellulose or ... accommodated by using interchangeable templates to form ... format Bio-Dot SF apparatus. Each is available ...
... The Bio-Dot and Bio-Dot SF (slot ... for binding protein or nucleic acid in ... experimental protocols can be accommodated by using ... apparatus or 48-well slot format Bio-Dot SF ...
Medicine Products: